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List of works by Sarah L Doyle

An eye on the future of inflammasomes and drug development in AMD.

scientific article published on 10 May 2013

An overview of the involvement of interleukin-18 in degenerative retinopathies.

scientific article published on January 2014

Attenuated CSF-1R signalling drives cerebrovascular pathology

scientific article published on 22 December 2020

Author Response: The Role of IL-18 in the Treatment of AMD.

scientific article published in December 2015

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

scientific article published on 30 April 2003

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide

scientific article

Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin

scientific article

Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.

scientific article published on 15 August 2012

Current perspectives on established and novel therapies for pathological neovascularization in retinal disease

scientific article published on 27 April 2019

Engagement of Fas differentially regulates the production of LPS-induced proinflammatory cytokines and type I interferons

scientific article published on 22 December 2018

IL-10 inhibits miR-155 induction by toll-like receptors

scientific article

IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates

scientific article published on August 2015

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration

scientific article (publication date: 2 April 2014)

Inflammation in age-related macular degeneration.

scientific article published on January 2014

Interleukin-18 bioactivity and dose: data interpretation at a crossroads

scientific article published on 23 December 2014

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye.

scientific article

Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

scientific article published on 05 September 2019

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

scientific article published on 26 January 2006

NLRP3 Inflammasome and Pathobiology in AMD

scientific article

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

scientific article

Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15

scientific article published on 19 July 2013

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

scientific article

Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population.

scientific article published on 16 February 2018

Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration

scientific article published on 01 December 2014

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

scientific article published on 20 April 2020

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase

scientific article

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

scientific article published on 15 January 2006

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway

scientific article

TRAM is required for TLR2 endosomal signaling to type I IFN induction

scientific article

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

scientific article

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation

scientific article

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

scientific article published on 27 May 2009

Toll-Like Receptors and Age-Related Macular Degeneration

scientific article published on 01 January 2018

Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity

scientific article

Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation

scientific article published on 06 July 2018

Using Confocal Microscopy to Investigate Intracellular Trafficking of Toll-Like Receptors.

scientific article published on January 2016

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