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List of works by Grahame Hardie

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

scientific article published in December 1995

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

scientific article published on 2 April 2007

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

scientific article published on October 2002

A neural protection racket: AMPK and the GABA(B) receptor

scientific article published on 01 January 2007

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.

scientific article

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

scientific journal article

A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes.

scientific article published in May 2002

AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.

scientific article published in March 2004

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

scientific article published on October 2013

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

scientific article

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

scientific article published on 27 December 2020

AMP-activated kinase regulates cytoplasmic HuR.

scientific article

AMP-activated protein kinase - not just an energy sensor.

scientific article published on 22 September 2017

AMP-activated protein kinase and hypoxic pulmonary vasoconstriction

scientific article published on 30 July 2008

AMP-activated protein kinase as a drug target.

scientific article published on January 2007

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

scientific article

AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP?

scientific article published on 19 February 2009

AMP-activated protein kinase--development of the energy sensor concept.

scientific article

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

scientific article

AMP-activated protein kinase: a master switch in glucose and lipid metabolism.

scientific article published on May 2004

AMP-activated protein kinase: a target for drugs both ancient and modern

scientific article

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

scientific article published on March 1999

AMP-activated protein kinase: the guardian of cardiac energy status.

scientific article published in August 2004

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

scientific article (publication date: October 2007)

AMPK and Raptor: matching cell growth to energy supply.

scientific article published in May 2008

AMPK and SNF1: Snuffing Out Stress.

scientific article

AMPK and autophagy get connected.

scientific article published on February 2011

AMPK and autophagy get connected.

scientific article published in June 2011

AMPK as a direct sensor of long-chain fatty acyl-CoA esters

scientific article published on 27 July 2020

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.

scientific article

AMPK: a key regulator of energy balance in the single cell and the whole organism.

scientific article published on September 2008

AMPK: a nutrient and energy sensor that maintains energy homeostasis ⬇️

scientific article (publication date: 22 March 2012)

AMPK: mediating the metabolic effects of salicylate-based drugs?

scientific article published on 19 July 2013

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

scientific article

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

scientific article published on 26 September 2014

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

scientific article

Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection ⬇️

scientific article published on November 9, 2011

Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.

scientific article published in January 1991

Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation

scientific journal article

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

scientific article published in February 2007

Amino acid sequence around the reactive serine residue of the thioesterase domain of rabbit fatty acid synthase

scientific article published on 01 April 1985

Analysis of the LKB1-STRAD-MO25 complex

scientific article

Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy

scientific article published on 06 July 2009

Biochemistry. Balancing cellular energy

scientific article published on 01 March 2007

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

scientific article

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl-CoA carboxylase and ATP-citrate lyase in isolated hepatocytes

scientific article published on 01 February 1985

Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase

scientific article published in August 1990

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

scientific article published on 27 January 2010

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

scientific journal article

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

scientific article published on 16 May 2005

Cell biology. Why starving cells eat themselves

scientific article published on 01 January 2011

Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.

scientific article published on February 2010

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

scientific article

Cloning of DNA encoding a catalytic subunit of SNF1-related protein kinase-1 (SnRK1-alpha1), and immunological analysis of multiple forms of the kinase, in spinach leaf

scientific article

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.

scientific article published in April 2011

DNA loops and semicatenated DNA junctions

scientific article

De-phosphorylation of MyoD is linking nerve-evoked activity to fast myosin heavy chain expression in rodent adult skeletal muscle

scientific article published on 30 August 2007

Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

scientific article

Dephosphorylation and activation of acetyl-CoA carboxylase from lactating rabbit mammary gland

scientific article

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

scientific article published on 22 September 2009

Distinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liver

scientific article published on 01 August 1997

Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.

scientific article published on March 1998

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

scientific article

Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism.

scientific article

Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase

scientific article published on 01 November 1992

Evidence that amiloride antagonises insulin-stimulated protein phosphorylation by inhibiting protein kinase activity

article

Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency

scientific article

Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase

scientific article published on 01 October 2007

Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle

scientific article

Histological evaluation of AMPK signalling in primary breast cancer

scientific article published in September 2009

Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase

scientific article

Immunological evidence that HMG-CoA reductase kinase-A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinases

scientific article published on 01 December 1995

Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?

scientific article published on 01 June 2004

Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.

scientific article published in June 2003

Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.

scientific article

Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides.

scientific article

Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors

scientific article published on April 2011

Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation

scientific article published on 07 October 2005

Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.

scientific article published on October 2009

Is hexokinase really a sugar sensor in plants?

scientific article published on 01 March 1999

Keeping the home fires burning: AMP-activated protein kinase.

scientific article

Key roles for AMP-activated protein kinase in the function of the carotid body?

scientific article published in January 2008

LKB1 and AMPK and the cancer-metabolism link - ten years after

scientific article

Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase

scientific article published on 01 January 1990

Mammalian fatty acid synthetase: evidence for subunit identity and specific removal of the thioesterase component using elastase digestion

scientific article published on 01 October 1978

Management of cellular energy by the AMP-activated protein kinase system

scientific article

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

scientific article

Metabolic control: a new solution to an old problem

scientific article

Metformin-acting through cyclic AMP as well as AMP?

scientific article published in March 2013

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

scientific article

Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.

scientific article

Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases

scientific article published on 01 August 1988

Neither LKB1 nor AMPK are the direct targets of metformin

scientific article published on 01 September 2006

New roles for the LKB1-->AMPK pathway.

scientific article

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. ⬇️

scientific article

PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway.

scientific article published in January 2005

PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.

scientific article published on 18 August 2010

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

scientific article

Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

scientific article published on 26 May 2005

Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes

scientific article published on 01 July 1992

Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase

scientific article published on 01 May 1999

Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

scientific article published on 17 October 2011

Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.

scientific article published on 19 April 2005

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

scientific article published on 28 February 2009

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.

scientific article published in March 2002

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

scientific article published in July 1994

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver

scientific article

Regulation of acetyl-CoA carboxylase: identity fo sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP-dependent protein kinase

scientific article published on 01 October 1980

Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

scientific article

Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase

scientific article

Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise.

scientific article

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

scientific article

Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP

scientific article published on 01 August 1999

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

scientific article published on 3 July 2006

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.

scientific article

Role of the AMP-activated protein kinase in the cellular stress response

scientific article published on 01 April 1994

SNF1-related protein kinases: global regulators of carbon metabolism in plants?

scientific article published in July 1998

Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase.

scientific article published on 5 January 2011

Sensing of energy and nutrients by AMP-activated protein kinase.

scientific article published on 16 February 2011

Signal transduction: How cells sense energy.

scientific article

Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I

scientific article published on 01 March 1995

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

scientific article

Small molecules can have big effects on endurance.

scientific article

Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.

scientific article published in November 1993

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

scientific article

The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA

scientific article published on 01 March 1995

The AMP-activated protein kinase pathway--new players upstream and downstream.

scientific article

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

scientific article (publication date: 1998)

The LKB1-AMPK pathway-friend or foe in cancer?

scientific article

The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1

scientific article published on 01 June 1999

The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase

scientific article

The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

scientific journal article

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

scientific article published in December 2004

The ancient drug salicylate directly activates AMP-activated protein kinase

scientific article

The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.

scientific article

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.

scientific article

The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase.

scientific article

The regulation of enzyme activity by reversible phosphorylation.

scientific article

The role of ATM in response to metformin treatment and activation of AMPK.

scientific article

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †

scientific article published on 10 July 2019

Transcription. Targeting the core of transcription.

scientific article

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.

scientific article

Ways of coping with stress

scientific article published in Nature

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