List of works - Timothy R. Rudd

19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

scientific article published on 15 August 2016

A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis ⬇️

scientific article published on February 27, 2012

A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

scientific article

A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-n-butoxyethyl) phosphate

scientific article published on 14 April 2011

A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation

scientific article published on 3 August 2012

An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence

scientific article

Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network.

scientific article published on 13 March 2013

Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils ⬇️

scientific article

CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source.

scientific article

CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source. Corrigendum

scientific article published on 30 April 2015

Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution

scientific article published in June 2009

Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships

scientific article published on 3 September 2010

Conformational degeneracy restricts the effective information content of heparan sulfate

scientific article published on 15 February 2010

Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis

scientific article

Data mining and visualisation: general discussion

scientific article published on 01 August 2019

Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism

scholarly article by Ashley J. Hughes et al published 2015 in Analytical Methods

Differentiation of generic enoxaparins marketed in the United States by employing NMR and multivariate analysis

scientific article

Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities.

scientific article published on 9 February 2008

Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity

scientific article

Following Protein–Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry

scientific article published on 01 January 2012

Fundamental differences in model cell-surface polysaccharides revealed by complementary optical and spectroscopic techniques

article

Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra

article

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain

scientific article published on 30 April 2020

Heparan sulfate and heparin interactions with proteins

scientific article

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding.

scientific article published on June 2015

Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment.

scientific article published on 05 April 2012

Heparin derivatives for the targeting of multiple activities in the inflammatory response

scientific article published on 7 October 2014

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

scientific article published on 29 April 2020

High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra

scientific article published on 31 January 2011

High-throughput SRCD using multi-well plates and its applications

scientific article published on 22 December 2016

How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin

scientific article published on 24 July 2012

Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution

scientific article

Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives

scientific article published on 18 June 2007

Inhibition of influenza H5N1 invasion by modified heparin derivatives

article

Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.

scientific article

Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides.

scientific article

Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches

MD Simulation of the Interaction between Sialoglycans and the Second Sialic Acid Binding Site of Influenza A Virus N1 Neuraminidase

scientific article published on 07 January 2020

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

scientific article published on 24 May 2019

Multivariate analysis applied to complex biological medicines

scientific article published on 01 August 2019

N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding

scientific article

NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF

scientific article published in 2022

New Applications of Heparin and Other Glycosaminoglycans.

scientific article published on 6 May 2017

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

scientific article

O-acetylation of typhoid capsular polysaccharide confers polysaccharide rigidity and immunodominance by masking additional epitopes

scientific article published on 31 May 2019

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+

article

Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes.

scientific article

Raman and Raman optical activity of glycosaminoglycans

scientific article published on 19 April 2010

Real-time monitoring of the development and stability of biofilms of Streptococcus mutans using the quartz crystal microbalance with dissipation monitoring

scientific article

Recent innovations in the structural analysis of heparin

scientific article published on June 2016

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins

scientific article published on 30 April 2020

Selective Detection of Protein Secondary Structural Changes in Solution Protein−Polysaccharide Complexes Using Vibrational Circular Dichroism (VCD)

article

Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.

scientific article

Survey of peptide quantification methods and comparison of their reproducibility: A case study using oxytocin

scientific article published on 19 December 2018

The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation.

scientific article published on January 2008

The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing

article published in 2010

The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis.

scientific article published on 20 March 2017

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

article

Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra

scientific article published on 29 July 2013

List of works by Timothy R. Rudd

19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis ⬇️

A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-n-butoxyethyl) phosphate

A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation

An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence

Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network.

Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils ⬇️

CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source.

CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source. Corrigendum

Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution

Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships

Conformational degeneracy restricts the effective information content of heparan sulfate

Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis

Data mining and visualisation: general discussion

Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism

Differentiation of generic enoxaparins marketed in the United States by employing NMR and multivariate analysis

Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities.

Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity

Following Protein–Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry

Fundamental differences in model cell-surface polysaccharides revealed by complementary optical and spectroscopic techniques

Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain

Heparan sulfate and heparin interactions with proteins

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding.

Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment.

Heparin derivatives for the targeting of multiple activities in the inflammatory response

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra

High-throughput SRCD using multi-well plates and its applications

How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin

Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution

Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives

Inhibition of influenza H5N1 invasion by modified heparin derivatives

Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.

Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides.

Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches

MD Simulation of the Interaction between Sialoglycans and the Second Sialic Acid Binding Site of Influenza A Virus N1 Neuraminidase

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

Multivariate analysis applied to complex biological medicines

N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding

NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF

New Applications of Heparin and Other Glycosaminoglycans.

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

O-acetylation of typhoid capsular polysaccharide confers polysaccharide rigidity and immunodominance by masking additional epitopes

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+

Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes.

Raman and Raman optical activity of glycosaminoglycans

Real-time monitoring of the development and stability of biofilms of Streptococcus mutans using the quartz crystal microbalance with dissipation monitoring

Recent innovations in the structural analysis of heparin

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins

Selective Detection of Protein Secondary Structural Changes in Solution Protein−Polysaccharide Complexes Using Vibrational Circular Dichroism (VCD)

Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.

Survey of peptide quantification methods and comparison of their reproducibility: A case study using oxytocin

The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation.

The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing

The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis.

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra