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List of works by Peter Brzezinski

A flash-photolysis study of the reactions of a caa3-type cytochrome oxidase with dioxygen and carbon monoxide

scientific article published on 01 December 1996

A ligand-exchange mechanism of proton pumping involving tyrosine-422 of subunit I of cytochrome oxidase is ruled out

scientific article published on 01 January 1996

A mechanistic principle for proton pumping by cytochrome c oxidase

scientific article

A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase

scholarly article

A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides results in an increase in steady-state activity but completely eliminates proton pumping

scientific article published in November 2002

A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O(2)-reduction activity

scientific article published in February 2010

A single-amino-acid lid renders a gas-tight compartment within a membrane-bound transporter

scholarly article

Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase

scientific article

Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocysteine lyase

scientific article

Control of transmembrane charge transfer in cytochrome c oxidase by the membrane potential

scientific article published in Nature Communications

Controlled uncoupling and recoupling of proton pumping in cytochrome c oxidase

scientific article

Crystal structures of DntR inducer binding domains in complex with salicylate offer insights into the activation of LysR‐type transcriptional regulators ⬇️

scientific article published on June 22, 2011

Cytochrome c oxidase as an electron-transport-driven proton pump: pH dependence of the reduction levels of the redox centers during turnover

scientific article published on 01 July 1988

Cytochrome c oxidase: exciting progress and remaining mysteries

scientific article

Development of a bacterial biosensor for nitrotoluenes: the crystal structure of the transcriptional regulator DntR.

scientific article

Directed evolution of the transcriptional regulator DntR: isolation of mutants with improved DNT-response

scientific article

EPR studies of wild‐type and several mutants of cytochrome c oxidase from Rhodobacter sphaeroides: Glu286 is not a bridging ligand in the cytochrome a3‐CuB center ⬇️

scientific article published on 01 November 1995

Electron and proton transfer in the ba(3) oxidase from Thermus thermophilus

scientific article published on 28 August 2008

Electron-proton interactions in terminal oxidases ⬇️

scientific article published on June 10, 1998

Electron-transport-driven proton pumps display nonhyperbolic kinetics: Simulation of the steady-state kinetics of cytochrome c oxidase

scientific article published on June 1986

Examination of the reaction of fully reduced cytochrome oxidase with hydrogen peroxide by flow-flash spectroscopy

scientific article

Exploration of the cytochrome c oxidase pathway puzzle and examination of the origin of elusive mutational effects

scientific article

Extraction and liposome reconstitution of membrane proteins with their native lipids without the use of detergents

scientific article published in Scientific Reports

Factors Determining Electron-Transfer Rates in Cytochrome c Oxidase: Studies of the FQ(I-391) Mutant of the Rhodobacter sphaeroides Enzyme ⬇️

scientific article published on September 30, 1997

Formation of the "peroxy" intermediate in cytochrome c oxidase is associated with internal proton/hydrogen transfer

scientific article published on 01 November 2000

Functional interactions between membrane-bound transporters and membranes ⬇️

scientific article published on August 23, 2010

Functional role of Thr-312 and Thr-315 in the proton-transfer pathway in ba3 Cytochrome c oxidase from Thermus thermophilus

scientific article

Glutamate 286 in Cytochrome aa3 from Rhodobacter sphaeroides Is Involved in Proton Uptake during the Reaction of the Fully-Reduced Enzyme with Dioxygen ⬇️

scientific article published on November 11, 1997

Impaired proton pumping in cytochrome c oxidase upon structural alteration of the D pathway

scientific article

In vivo and in vitro investigation of transcriptional regulation by DntR

scientific article

Inhibition of proton transfer in cytochrome c oxidase by zinc ions: delayed proton uptake during oxygen reduction

scientific article published on 01 September 2002

Intermediates generated during the reaction of reduced Rhodobacter sphaeroides cytochrome c oxidase with dioxygen ⬇️

scientific article published on April 30, 2013

Internal charge transfer in cytochrome c oxidase at a limited proton supply: proton pumping ceases at high pH.

scientific article published on 31 March 2009

Internal electron transfer in cytochrome c oxidase from Rhodobacter sphaeroides

scientific article published on 01 March 1995

Internal electron transfer in cytochrome c oxidase is coupled to the protonation of a group close to the bimetallic site

scientific article published on 01 February 1994

Intramolecular proton-transfer reactions in a membrane-bound proton pump: the effect of pH on the peroxy to ferryl transition in cytochrome c oxidase

scientific article

Intricate Role of Water in Proton Transport through Cytochrome c Oxidase ⬇️

scientific article published on October 21, 2010

Isolation of yeast complex IV in native lipid nanodiscs

scientific article

Kinetic coupling between electron and proton transfer in cytochrome c oxidase: simultaneous measurements of conductance and absorbance changes

scientific article published on October 1996

Kinetic design of the respiratory oxidases

scientific article

Kinetics of electron and proton transfer during O(2) reduction in cytochrome aa(3) from A. ambivalens: an enzyme lacking Glu(I-286).

scientific article

Kinetics of electron and proton transfer during the reaction of wild type and helix VI mutants of cytochrome bo3 with oxygen.

scientific article

Lateral proton transfer between the membrane and a membrane protein

scientific article published in March 2009

Ligand binding and the catalytic reaction of cytochrome caa(3) from the thermophilic bacterium Rhodothermus marinus

scientific article published in September 2001

Ligand binding reveals protonation events at the active site of cytochrome c oxidase; is the K-pathway used for the transfer of H(+) or OH(-)?

scientific article

Light-induced structural changes in cytochrome c oxidase. Measurements of electrogenic events and absorbance changes

scientific article published on 01 March 1993

Light-induced structural changes in cytochrome c oxidase: implication for the mechanism of electron and proton gating

scientific article published on 01 March 1994

Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis

scientific article

Localized control of proton transfer through the D-pathway in cytochrome c oxidase: application of the proton-inventory technique

scientific article published in June 2000

Localized proton microcircuits at the biological membrane-water interface

scholarly article

Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidase

scholarly article

Mimicking respiratory phosphorylation using purified enzymes

scientific article

Modeling gating charge and voltage changes in response to charge separation in membrane proteins

scientific article

Modulation of O2 reduction in Saccharomyces cerevisiae mitochondria

scientific article published on 24 November 2017

Molecular architecture of the proton diode of cytochrome c oxidase

scientific article published on December 2008

Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site

scientific article

NMR study of Rcf2 reveals an unusual dimeric topology in detergent micelles

scientific article

Observation of a novel transient ferryl complex with reduced CuB in cytochrome c oxidase

scientific article published on 01 February 1999

On the role of the K-proton transfer pathway in cytochrome c oxidase

scholarly article

Pathways of proton transfer in cytochrome c oxidase

scientific article published on February 1, 1998

Photoinduced electron transfer from carboxymethylated cytochrome c to plastocyanin ⬇️

scientific article published on May 27, 1998

Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump

scientific article published on August 2009

Proton pumping by an inactive structural variant of cytochrome c oxidase

scientific article published in July 2014

Proton transfer from glutamate 286 determines the transition rates between oxygen intermediates in cytochrome c oxidase

scientific article published on 01 August 2000

Proton transfer in ba(3) cytochrome c oxidase from Thermus thermophilus

scientific article

Proton uptake controls electron transfer in cytochrome c oxidase

scientific article published on November 1998

Proton-coupled structural changes upon binding of carbon monoxide to cytochrome cd1: a combined flash photolysis and X-ray crystallography study

scientific article

Proton-transport mechanisms in cytochrome c oxidase revealed by studies of kinetic isotope effects

scientific article published on 2 April 2011

Protonation Dynamics on Lipid Nanodiscs: Influence of the Membrane Surface Area and External Buffers

scientific article published on May 2016

Reaction of S. cerevisiae mitochondria with ligands: Kinetics of CO and O2 binding to flavohemoglobin and cytochrome c oxidase

scientific article published on 18 November 2016

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer

scientific article

Redesign of the proton-pumping machinery of cytochrome c oxidase: proton pumping does not require Glu(I-286)

scientific article published on 01 December 2000

Redox-coupled proton translocation in biological systems: proton shuttling in cytochrome c oxidase

scientific article

Redox-driven proton pumping by heme-copper oxidases

scientific article

Regulatory role of the respiratory supercomplex factors in Saccharomyces cerevisiae

scientific article

Relocation of an internal proton donor in cytochrome c oxidase results in an altered pK(a) and a non-integer pumping stoichiometry

scientific article published on 01 July 2002

Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pump

scientific article published on November 2006

Role of aspartate 132 at the orifice of a proton pathway in cytochrome c oxidase

scientific article published on 14 May 2013

Role of the Pathway through K(I-362) in Proton Transfer in Cytochrome c Oxidase from R. sphaeroides ⬇️

scientific article published on February 24, 1998

SNARE-fusion mediated insertion of membrane proteins into native and artificial membranes

scientific article

Single mutations that redirect internal proton transfer in the ba3 oxidase from Thermus thermophilus

scientific article

Site-directed mutagenesis of residues lining a putative proton transfer pathway in cytochrome c oxidase from Rhodobacter sphaeroides

scientific article published on 01 October 1996

Structural Changes and Proton Transfer in Cytochrome c Oxidase

scientific article published on 27 August 2015

Structural elements involved in electron-coupled proton transfer in cytochrome c oxidase

scientific article published on June 2004

Structural elements involved in proton translocation by cytochrome c oxidase as revealed by backbone amide hydrogen-deuterium exchange of the E286H mutant

scientific article published on 6 December 2007

Subunit III of cytochrome c oxidase of Rhodobacter sphaeroides is required to maintain rapid proton uptake through the D pathway at physiologic pH

scientific article published on 01 June 2003

Surface-coupled proton exchange of a membrane-bound proton acceptor

scientific article

Surface-mediated proton-transfer reactions in membrane-bound proteins

scientific article published on April 2004

The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides

scientific article

The catalytic mechanism of gastric H+/K+-ATPase: simulations of pre-steady-state and steady-state kinetic results

scientific article published in July 1988

The effect of pH and temperature on the reaction of fully reduced and mixed-valence cytochrome c oxidase with dioxygen

scientific article published in December 1989

The electron distribution in the "activated" state of cytochrome c oxidase.

scientific article

The entry point of the K-proton-transfer pathway in cytochrome c oxidase

scientific article published in September 2002

The lateral distance between a proton pump and ATP synthase determines the ATP-synthesis rate

scientific article

The mechanism of electron gating in proton pumping cytochrome c oxidase: the effect of pH and temperature on internal electron transfer

scientific article published on 01 October 1987

The membrane modulates internal proton transfer in cytochrome c oxidase

scientific article

The onset of the deuterium isotope effect in cytochrome c oxidase

scientific article

The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase

scientific article published in August 2005

The rate of internal heme-heme electron transfer in cytochrome C oxidase

scientific article published on 01 August 2002

The rate-limiting step and nonhyperbolic kinetics in the oxidation of ferrocytochrome c catalyzed by cytochrome c oxidase

scientific article published on 01 January 1986

The reduction of cytochrome c oxidase by carbon monoxide

scientific article published on 01 July 1985

The solution configurations of inactive and activated DntR have implications for the sliding dimer mechanism of LysR transcription factors

scientific article published on 28 January 2016

The timing of proton migration in membrane-reconstituted cytochrome c oxidase

scholarly article

Timing of electron and proton transfer in the ba(3) cytochrome c oxidase from Thermus thermophilus

scientific article

Transient Binding of CO to CuB in Cytochrome c Oxidase Is Dynamically Linked to Structural Changes around a Carboxyl Group: A Time-Resolved Step-Scan Fourier Transform Infrared Investigation ⬇️

scientific article published on January 1, 2002

Transmembrane proton translocation by cytochrome c oxidase

scientific article published on 19 May 2006

Triplet-state quenching in complexes between Zn-cytochrome c and cytochrome oxidase or its CuA domain

scientific article published on April 1995

Two-electron reduction is required for rapid internal electron transfer in resting, pulsed and oxygenated cytochrome c oxidase

scientific article published on 01 March 1987

Variable proton-pumping stoichiometry in structural variants of cytochrome c oxidase

scientific article published on 23 February 2010

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