List of works - Philip Eaton

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

scientific article published on 17 May 2019

A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method.

scientific article published on January 2010

A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation

scientific article published on 18 August 2021

Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability.

scientific article published on 18 November 2015

Biochemical methods for monitoring protein thiol redox states in biological systems

scientific article

Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase

scientific article published on 22 May 2019

Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.

scientific article published on 7 December 2007

Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation.

scientific article published on October 2011

Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System

scientific article published on 14 September 2018

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice

scientific article published on 10 August 2015

Detecting disulfide-bound complexes and the oxidative regulation of cyclic nucleotide-dependent protein kinases by H2O2.

scientific article published in January 2013

Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion

scientific article

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure.

scientific article published on 15 March 2017

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.

scientific article published on 26 October 2016

Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo.

scientific article published on 17 March 2011

Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation.

scientific article published on 12 January 2018

Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity

scientific article published on 6 July 2017

Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain

scientific article published on 12 September 2018

Frontiers in nitric oxide and redox signaling

scientific article published on 10 May 2011

Gel-based methods in redox proteomics ⬇️

scientific article published on April 23, 2013

Heart failure—emerging roles for the mitochondrial pyruvate carrier

scientific article published in 2021

How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?

scientific article published on 8 February 2017

Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations.

scientific article published on 19 February 2008

Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system.

scientific article published on 17 September 2012

Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation

scientific article published on 16 November 2021

Intensity matters: Ryanodine receptor regulation during exercise

scientific article

Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase

scientific article (publication date: 2004)

Ischemic preconditioning: a potential role for constitutive low molecular weight stress protein translocation and phosphorylation?

scientific article published in June 2000

Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research

scientific article published on 14 December 2013

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

scientific article published on 26 October 2020

Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

scientific article published on 29 March 2019

Nitrosative protein oxidation is modulated during early endotoxemia.

scientific article published on 2 December 2010

Oxidant sensing by protein kinases a and g enables integration of cell redox state with phosphoregulation.

scientific article published on 26 March 2010

Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity.

scientific article published on 30 August 2017

Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2.

scientific article published on 4 March 2016

Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury.

scientific article

Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation

scientific article published on 05 June 2006

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

scientific article published on 11 June 2019

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

scientific article published on 23 August 2018

PKG1α oxidation negatively regulates food seeking behaviour and reward

scientific article published on 18 December 2018

Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling ⬇️

scientific article published on July 24, 2012

Peroxynitrite: in vivo cardioprotectant or arrhythmogen?

scientific article published on 22 September 2008

Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation.

scientific article published on 19 January 2016

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.

scientific article published on 24 June 2016

Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury.

scientific article

Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation

scientific article published on 14 May 2015

Preface for redox signalling in the cardiovascular system

scientific article published on 10 May 2014

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

scientific article published on 11 October 2016

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart.

scientific article published on 4 May 2015

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα).

scientific article

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase

scientific article

Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.

scientific article published on 29 September 2014

Protein kinase G oxidation is a major cause of injury during sepsis.

scientific article published on 28 May 2013

Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue

scientific article

Protein thiol oxidation in health and disease: techniques for measuring disulfides and related modifications in complex protein mixtures.

scientific article

Redox modification of cell signaling in the cardiovascular system

scientific article

Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system

scientific article

Redox signaling in cardiac physiology and pathology.

scientific article published on September 2012

Redox signalling in cardiovascular disease.

scientific article published on 06 May 2008

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3.

scientific article published on 24 July 2017

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.

scientific article published on 07 December 2016

Response to "Detailed aspects of redox signaling in cardiac physiology and pathology".

scientific article

Reversible cysteine-targeted oxidation of proteins during renal oxidative stress

scientific article published in August 2003

Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart.

scientific article

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

scientific article published on 2 February 2016

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

scientific article published on 15 January 2012

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

scientific article published on 13 February 2019

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

scientific article published on 23 August 2018

The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation

scientific article

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling

scientific article published on 30 November 2015

Transnitrosylating nitric oxide species directly activate type I protein kinase A, providing a novel adenylate cyclase-independent cross-talk to beta-adrenergic-like signaling.

scientific article published on 2 September 2009

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

scientific article

List of works by Philip Eaton

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method.

A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation

Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability.

Biochemical methods for monitoring protein thiol redox states in biological systems

Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase

Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.

Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation.

Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice

Detecting disulfide-bound complexes and the oxidative regulation of cyclic nucleotide-dependent protein kinases by H2O2.

Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure.

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.

Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo.

Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation.

Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity

Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain

Frontiers in nitric oxide and redox signaling

Gel-based methods in redox proteomics ⬇️

Heart failure—emerging roles for the mitochondrial pyruvate carrier

How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?

Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations.

Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system.

Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation

Intensity matters: Ryanodine receptor regulation during exercise

Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase

Ischemic preconditioning: a potential role for constitutive low molecular weight stress protein translocation and phosphorylation?

Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

Nitrosative protein oxidation is modulated during early endotoxemia.

Oxidant sensing by protein kinases a and g enables integration of cell redox state with phosphoregulation.

Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity.

Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2.

Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury.

Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

PKG1α oxidation negatively regulates food seeking behaviour and reward

Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling ⬇️

Peroxynitrite: in vivo cardioprotectant or arrhythmogen?

Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation.

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.

Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury.

Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation

Preface for redox signalling in the cardiovascular system

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart.

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα).

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase

Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.

Protein kinase G oxidation is a major cause of injury during sepsis.

Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue

Protein thiol oxidation in health and disease: techniques for measuring disulfides and related modifications in complex protein mixtures.

Redox modification of cell signaling in the cardiovascular system

Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system

Redox signaling in cardiac physiology and pathology.

Redox signalling in cardiovascular disease.

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3.

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.

Response to "Detailed aspects of redox signaling in cardiac physiology and pathology".

Reversible cysteine-targeted oxidation of proteins during renal oxidative stress

Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart.

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling

Transnitrosylating nitric oxide species directly activate type I protein kinase A, providing a novel adenylate cyclase-independent cross-talk to beta-adrenergic-like signaling.

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide