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List of works by L. Darryl Quarles

A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model.

scientific article

A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia

scientific article published on 22 November 2016

A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor.

scientific article published on March 1997

A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease.

scientific article published on March 2013

ASARM mineralization hypothesis: a bridge too far?

scientific article

Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl.

scientific article published in February 2005

Activation of FGF-23 mediated vitamin D degradative pathways by cholecalciferol.

scientific article

Aluminum accumulation in patients with chronic renal disease

scientific article published on 01 July 1991

Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.

scientific article published on September 1994

Aluminum-induced neo-osteogenesis: a generalized process affecting trabecular networking in the axial skeleton

scientific article published on 01 June 1990

An experimental canine model of osteonecrosis: characterization of the repair process

scientific article published on 01 May 1993

Analysis of failures after vascularized fibular grafting in femoral head necrosis

scientific article published on 01 July 2004

Angiotensin-converting enzyme inhibitor, angiotensin receptor blocker use, and mortality in patients with chronic kidney disease

scientific article

Antiandrogen gold nanoparticles dual-target and overcome treatment resistance in hormone-insensitive prostate cancer cells.

scientific article

Association of body mass index with outcomes in patients with CKD.

scientific article

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

scientific article

Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study

scientific article

Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.

scientific article

Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.

scientific article

CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

scientific article

Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets

scientific article published on 6 February 2008

Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift?

scientific article published on 28 October 2008

Calcium regulates FGF-23 expression in bone

scientific article published on 18 October 2013

Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism.

scientific article

Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.

scientific article

Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II

scientific article published in Scientific Reports

Chronic kidney disease and diabetes mellitus predict resistance to vitamin D replacement therapy.

scientific article published in April 2013

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

scientific article published on 11 August 2006

Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity

scientific article published on September 1, 2011

Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis

scientific article published on 01 April 1999

Comparison of treatments for mild secondary hyperparathyroidism in hemodialysis patients. Durham Renal Osteodystrophy Study Group

article

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype ⬇️

scientific article published on December 7, 2010

Computationally identified novel agonists for GPRC6A.

scientific article published on 23 April 2018

Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.

scientific article published on 3 February 2016

Conditional deletion ofPkd1in osteocytes disrupts skeletal mechanosensing in mice ⬇️

scientific article published on March 31, 2011

Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.

scientific article

Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.

scientific article

Construction of a Full-Length Murine Proα2(I) Collagen cDNA by the Polymerase Chain Reaction ⬇️

scientific article published on December 1, 1991

Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages.

scientific article published on 18 December 2015

Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension.

scientific article published on 19 August 2016

Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development

scientific article published on June 1, 1992

Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice.

scientific article published on 11 September 2007

Dose-dependent effects of Runx2 on bone development.

scientific article

Economic Analysis of Cinacalcet in Combination With Low-Dose Vitamin D Versus Flexible-Dose Vitamin D in Treating Secondary Hyperparathyroidism in Hemodialysis Patients ⬇️

scientific article published on October 15, 2010

Effect of asymmetric dimethylarginine on osteoblastic differentiation ⬇️

scientific article published on November 1, 2001

Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD.

scientific article

Effects of etidronate-mediated suppression of bone remodeling on aluminum-induced de novo bone formation ⬇️

scientific article published on July 1, 1992

Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiation.

scientific article published in June 2003

Elevated FGF23 levels are associated with impaired calcium-mediated suppression of PTH in ESRD.

scientific article

Endocrine functions of bone in mineral metabolism regulation.

scientific article published on December 2008

Enhanced FGF23 production in mice expressing PI3K-insensitive GSK3 is normalized by β-blocker treatment.

scientific article

Ensemble docking to difficult targets in early-stage drug discovery: Methodology and application to fibroblast growth factor 23.

scientific article published on 25 September 2017

Equivalency of various methods for estimating osteoid seam width

scientific article published on 01 October 1989

Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis.

scientific article published on January 2012

Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells

scientific article published on 23 March 2016

FGF-23 serum levels and bone histomorphometric results in adult patients with chronic kidney disease on dialysis

scientific article

FGF23 from bench to bedside.

scientific article published on 10 February 2016

Fibroblast growth factor 23 and α-Klotho co-dependent and independent functions

scientific article published on 01 January 2019

Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

scientific article

Fibroblast growth factor-23: what we know, what we don't know, and what we need to know ⬇️

scientific article published on April 25, 2013

Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts ⬇️

scientific article published on November 1, 1995

GPCR6A is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea.

scientific article published on 21 February 2018

GPRC6A Mediates the Effects of l-Arginine on Insulin Secretion in Mouse Pancreatic Islets ⬇️

scientific article published on August 7, 2012

GPRC6A Mediates the Non-genomic Effects of Steroids ⬇️

scientific article published on October 13, 2010

GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome

scientific article

GPRC6A regulates prostate cancer progression

scientific article

GPRC6A: Jack of all metabolism (or master of none).

scientific article published on 21 December 2016

Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor ⬇️

scientific article published on July 3, 1998

Guidelines for disorders of mineral metabolism and secondary hyperparathyroidism should not yet be modified.

scientific article published in June 2006

How fibroblast growth factor 23 works

scientific article

Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells

scientific article published on 20 March 2019

Hyperphosphatemia in end-stage renal disease.

scientific article

IRES-dependent translational control of Cbfa1/Runx2 expression.

scientific article published on February 2003

Identification of Putative Transmembrane Receptor Sequences Homologous to the Calcium-Sensing G-Protein-Coupled Receptor ⬇️

scientific article published on October 15, 1997

Identification of a novel extracellular cation-sensing G-protein-coupled receptor

scientific article

Inducible expression of Runx2 results in multiorgan abnormalities in mice.

scientific article published on February 2011

Inhibition of MEPE cleavage by Phex.

scientific article published in September 2002

Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia ⬇️

scientific article published on July 1, 1992

Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis

scientific article

Late vascular complications of the subclavian dialysis catheter

scientific article published on 01 March 1986

Letter to the Editor: "Increased Circulating FGF23 Does Not Lead to Cardiac Hypertrophy in the Male Hyp Mouse Model of XLH"

scientific article published on 01 November 2018

Linkage of a Gene Causing Familial Focal Segmental Glomerulosclerosis to Chromosome 11 and Further Evidence of Genetic Heterogeneity

article

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

scientific article published on 8 October 2006

Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination

scientific article

MEPE has the properties of an osteoblastic phosphatonin and minhibin.

scientific article published on February 2004

Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23

scientific article

Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23.

scientific article

Molecular to pharmacologic control of osteoblast proliferation and differentiation

scientific article published on 01 July 1994

Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks

scientific article

Multiple faces of fibroblast growth factor-23

scientific article published on 23 May 2016

Musculoskeletal Complications After Renal Transplantation: Pathogenesis and Treatment ⬇️

scientific article published on February 1, 1992

Novel bone endocrine networks integrating mineral and energy metabolism

scientific article

Novel regulators of Fgf23 expression and mineralization in Hyp bone

scientific article published on 25 June 2009

Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity

scientific article

Osteocyte-specific deletion of Fgfr1 suppresses FGF23

scientific article

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.

scientific article

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.

scientific article

Parathyroid-specific interaction of the calcium-sensing receptor and G alpha q.

scientific article published on 27 August 2008

Pathogenic role of Fgf23 in Dmp1-null mice.

scientific article published on 17 June 2008

Pathogenic role of Fgf23 in Hyp mice.

scientific article published on 31 January 2006

Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem

scientific article published on 01 February 2001

Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

scientific article

Physiological mechanisms and therapeutic potential of bone mechanosensing.

scientific article

Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis

scientific article published on 27 November 2017

Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.

scientific article published on 5 March 2008

Preventing bone loss after renal transplantation with bisphosphonates: we can... but should we?

scientific article published on 01 February 2000

Quantitative analysis of the calcium-sensing receptor messenger RNA in parathyroid adenomas ⬇️

scientific article published on December 1, 1997

RNA interference and its application in bone-related diseases.

scientific article published on 31 July 2007

Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new ⬇️

scientific article published on 09 January 2013

Reforming medicare's dialysis payment policies: implications for patients with secondary hyperparathyroidism

scientific article

Relationship between reductions in parathyroid hormone and serum phosphorus during the management of secondary hyperparathyroidism with calcimimetics in hemodialysis patients

scientific article published on 29 November 2012

Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation

scientific article published on 08 August 2007

Resveratrol prevents CsA inhibition of proliferation and osteoblastic differentiation of mouse bone marrow-derived mesenchymal stem cells through an ER/NO/cGMP pathway.

scientific article published on 9 March 2006

Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype

scientific article published on 01 September 2001

Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease ⬇️

scientific article published on March 7, 2012

Role of Fibroblast Growth Factor-23 in Innate Immune Responses.

scientific article

Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease.

scientific article published on July 2007

Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice

scientific article published on 06 June 2007

Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia

scientific journal article

Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis.

scientific article published on 7 March 2004

Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism.

scientific article

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

scientific article

Spectrum of disease in familial focal and segmental glomerulosclerosis

scientific article published on 01 November 1999

Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues

scientific article

Survival advantage in black versus white men with CKD: effect of estimated GFR and case mix.

scientific article

Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.

scientific article published on 7 December 2004

The bone and beyond: 'Dem bones' are made for more than walking.

scientific article published on April 2011

The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease.

scientific article published in March 2003

The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia.

scientific article published on 05 July 2016

The role of fibroblast growth factor-23 in cardiorenal syndrome.

scientific article

Validation of a Novel Modified Aptamer-Based Array Proteomic Platform in Patients with End-Stage Renal Disease

scientific article

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