List of works - Gavin P. Robertson

A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity

scientific article published on 14 May 2015

A nonradioactive plate-based assay for stimulators of nonspecific DNA nicking by HIV-1 integrase and other nucleases

scientific article published on 11 September 2009

A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.

scientific article

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

scientific article

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

scientific article published on May 2008

Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression

scientific article published on 15 March 2011

BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.

scientific article

CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas.

scientific article published on 22 July 2013

Chemoprevention of melanoma

scientific article published on 01 January 2012

Circulating melanoma cells in the diagnosis and monitoring of melanoma: an appraisal of clinical potential.

scientific article published on April 2014

Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

scientific article published on 16 June 2015

Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.

scientific article

Effect of lysosomotropic molecules on cellular homeostasis

scientific article published on 23 December 2016

Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds

scientific article

Functional and therapeutic significance of Akt deregulation in malignant melanoma.

scientific article

Growth inhibitory effects of large subunit ribosomal proteins in melanoma.

scientific article published on 16 June 2014

Identification of Aurora Kinase B and Wee1-Like Protein Kinase as Downstream Targets of V600EB-RAF in Melanoma ⬇️

scientific article published on February 12, 2013

Identification of WEE1 as a target to make AKT inhibition more effective in melanoma.

scientific article

Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma

scientific article

Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development.

scientific article published on January 2009

In situ photoimmunotherapy: a new hope for cutaneous melanoma patients.

scientific article

In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma ⬇️

scientific article published on August 4, 1998

Is B-Raf a good therapeutic target for melanoma and other malignancies?

scientific article published on January 2008

KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment.

scientific article

Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.

scientific article

Macrophage inhibitory cytokine-1 regulates melanoma vascular development

scientific article

Malignant melanoma-The cradle of anti-neoplastic immunotherapy

scientific article published on 7 May 2016

Melanoma Prevention Using Topical PBISe ⬇️

scientific article published on March 2, 2011

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.

scientific article published on 19 November 2010

Method of mutation analysis may contribute to discrepancies in reports of (V599E)BRAF mutation frequencies in melanocytic neoplasms

scientific article published on 01 November 2004

Mig-7 linked to vasculogenic mimicry

scientific article

Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.

scientific article

Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.

scientific article published on 21 December 2016

Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy

scientific article published on 27 January 2016

Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.

scientific article published on 4 November 2007

Predicting therapy response in live tumor cells isolated with the flexible micro spring array device.

scientific article published on 11 June 2013

Propagation of Undifferentiated Human Embryonic Stem Cells with Nano-Liposomal Ceramide

scientific article published in January 2009

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

scientific article

Ptena and ptenb genes play distinct roles in zebrafish embryogenesis.

scientific article published on December 2005

Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns

scientific article

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

scientific article

Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p

scientific article published on 07 January 2014

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

scientific article

Robust activation of the human but not mouse telomerase gene during the induction of pluripotency.

scientific article

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

scientific article published on 11 November 2018

Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils.

scientific article published on 6 December 2010

Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma

scientific article published on 30 October 2012

Steroid hormones drive cancer development ⬇️

scientific article published on October 15, 2010

Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth.

scientific article published on 18 October 2016

Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates.

scientific article published on December 2008

Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.

scientific article published on 22 September 2009

Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

scientific article

Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

scientific article

Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.

scientific article

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

scientific article

Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases

scientific article published on August 2006

Targeting multiple key signaling pathways in melanoma using leelamine.

scientific article

Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation.

scientific article published on June 2007

Targeting protein kinase-b3 (akt3) signaling in melanoma

scientific article published on 9 January 2017

Targeting sphingosine kinase-1 to inhibit melanoma.

scientific article published on March 2012

The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

scientific article published on 15 December 2011

The Role of Cholesterol in Cancer

scientific article published on 5 April 2016

Therapeutic Implications of Targeting AKT Signaling in Melanoma

scientific article

Therapeutic interventions to disrupt the protein synthetic machinery in melanoma

scientific article

Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development

scientific article

Use of Nanotechnology to Develop Multi-Drug Inhibitors For Cancer Therapy

scientific article

Use of liposomes as drug delivery vehicles for treatment of melanoma.

scientific article published on 22 May 2009

eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.

scientific article published on 9 February 2011

List of works by Gavin P. Robertson

A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity

A nonradioactive plate-based assay for stimulators of nonspecific DNA nicking by HIV-1 integrase and other nucleases

A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression

BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.

CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas.

Chemoprevention of melanoma

Circulating melanoma cells in the diagnosis and monitoring of melanoma: an appraisal of clinical potential.

Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway

Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.

Effect of lysosomotropic molecules on cellular homeostasis

Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds

Functional and therapeutic significance of Akt deregulation in malignant melanoma.

Growth inhibitory effects of large subunit ribosomal proteins in melanoma.

Identification of Aurora Kinase B and Wee1-Like Protein Kinase as Downstream Targets of V600EB-RAF in Melanoma ⬇️

Identification of WEE1 as a target to make AKT inhibition more effective in melanoma.

Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma

Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development.

In situ photoimmunotherapy: a new hope for cutaneous melanoma patients.

In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma ⬇️

Is B-Raf a good therapeutic target for melanoma and other malignancies?

KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment.

Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.

Macrophage inhibitory cytokine-1 regulates melanoma vascular development

Malignant melanoma-The cradle of anti-neoplastic immunotherapy

Melanoma Prevention Using Topical PBISe ⬇️

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.

Method of mutation analysis may contribute to discrepancies in reports of (V599E)BRAF mutation frequencies in melanocytic neoplasms

Mig-7 linked to vasculogenic mimicry

Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.

Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.

Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy

Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.

Predicting therapy response in live tumor cells isolated with the flexible micro spring array device.

Propagation of Undifferentiated Human Embryonic Stem Cells with Nano-Liposomal Ceramide

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

Ptena and ptenb genes play distinct roles in zebrafish embryogenesis.

Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

Robust activation of the human but not mouse telomerase gene during the induction of pluripotency.

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils.

Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma

Steroid hormones drive cancer development ⬇️

Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth.

Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates.

Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.

Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases

Targeting multiple key signaling pathways in melanoma using leelamine.

Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation.

Targeting protein kinase-b3 (akt3) signaling in melanoma

Targeting sphingosine kinase-1 to inhibit melanoma.

The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

The Role of Cholesterol in Cancer

Therapeutic Implications of Targeting AKT Signaling in Melanoma

Therapeutic interventions to disrupt the protein synthetic machinery in melanoma

Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development

Use of Nanotechnology to Develop Multi-Drug Inhibitors For Cancer Therapy

Use of liposomes as drug delivery vehicles for treatment of melanoma.

eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.