List of works - Stuart A Nicklin

A Novel Mechanism of Action for Angiotensin-(1–7) via the Angiotensin Type 1 Receptor

scientific article published on 03 October 2016

AAV-based gene transfer

scientific article published on August 1, 2003

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

scientific article

Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

scientific article published on October 2005

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor

scientific article

Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo.

scientific article

Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

scientific article published in 2022

Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop

scientific article published on 23 January 2007

Adenovirus serotype 5 hexon mediates liver gene transfer

scientific article published in February 2008

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling

scientific article published on June 2014

Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor

scientific journal article

Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor

scientific journal article

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action

scientific article published on 11 September 2012

Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion

scientific article published on 28 February 2019

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

scientific article published on 22 May 2012

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

scientific article

Capsid modification strategies for detargeting adenoviral vectors

scientific article published on January 2014

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

scientific article (publication date: 4 August 2015)

Cell-selective viral gene delivery vectors for the vasculature

scientific article

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function.

scientific article published on March 2014

Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum

scientific article

Development of efficient viral vectors selective for vascular smooth muscle cells

scientific article published in February 2004

Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.

scientific article

Dual targeting of gene delivery by genetic modification of adenovirus serotype 5 fibers and cell-selective transcriptional control.

scientific article published on August 2004

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats

scientific article published on August 2004

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

scientific article published on 22 October 2008

Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery

article

Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector

scientific article

Electrical consequences of cardiac myocyte: fibroblast coupling

scientific article published on June 2015

Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.

scientific article published on 15 November 2007

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

scientific article

FX and host defense evasion tactics by adenovirus

scientific article published on June 2013

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

scientific article published on 10 March 2015

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation

scientific article published on 12 April 2016

GPR35 as a Novel Therapeutic Target.

scientific article published on 9 November 2011

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction

scientific article published on December 2016

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

scientific article

Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

scientific article published on 05 July 2019

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

scientific article published on 08 May 2009

Identification of peptides that target the endothelial cell-specific LOX-1 receptor.

scientific article published on February 2001

In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors.

scientific article published on March 2004

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

scientific article

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

scientific article published on 24 January 2007

Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.

scientific article published on October 2008

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

scientific article published on 6 February 2015

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

scientific article published on February 2009

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

scientific article published on 20 June 2006

Novel vectors for in vivo gene delivery to vascular tissue

scientific article published on June 2007

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

scientific article published on 16 February 2009

Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts

scientific article published in May 2004

Prevention of coronary in-stent restenosis and vein graft failure: does vascular gene therapy have a role?

scientific article published on 14 July 2012

Promoters and control elements: designing expression cassettes for gene therapy.

scientific article published on March 2004

Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system

scientific article published on January 2013

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

scientific article

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

scientific article published on 16 May 2016

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

scientific article

Simple Methods for Preparing Recombinant Adenoviruses for High-Efficiency Transduction of Vascular Cells

article by S A Nicklin et al published 1999 in Methods in Molecular Medicine

Special focus issue on the annual meeting of the British Society for Gene and Cell Therapy

scientific article published in May 2015

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

scientific article published on 16 May 2019

Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors

scientific article

Targeting gene therapy vectors to the vascular endothelium

scientific article

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

scientific article

The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

scientific article published on 10 October 2013

The frequency of hemochromatosis-associated alleles is increased in British patients with sporadic porphyria cutanea tarda

The frequency of the haemochromatosis-associated genotype D6S265-1:D6S105-8 in blood donors

scientific article published on 01 June 1996

The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery

scientific article published on 18 July 2014

The influence of adenovirus fiber structure and function on vector development for gene therapy

scientific article

The relevance of coagulation factor X protection of adenoviruses in human sera.

scientific article published on 25 March 2016

Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy

scientific article

Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors

scientific article published in November 2003

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

scientific article

Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy

scientific article

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

scientific article

Use of phage display to identify novel peptides for targeted gene therapy

scientific article published on January 2002

Utilizing proteomics to understand and define hypertension: where are we and where do we go?

scientific article published on 12 July 2018

Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses

scientific article published on 4 January 2006

Vector systems for prenatal gene therapy: principles of adenovirus design and production

scientific article published in January 2012

List of works by Stuart A Nicklin

A Novel Mechanism of Action for Angiotensin-(1–7) via the Angiotensin Type 1 Receptor

AAV-based gene transfer

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor

Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo.

Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop

Adenovirus serotype 5 hexon mediates liver gene transfer

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling

Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor

Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action

Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Capsid modification strategies for detargeting adenoviral vectors

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

Cell-selective viral gene delivery vectors for the vasculature

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function.

Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum

Development of efficient viral vectors selective for vascular smooth muscle cells

Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.

Dual targeting of gene delivery by genetic modification of adenovirus serotype 5 fibers and cell-selective transcriptional control.

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery

Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector

Electrical consequences of cardiac myocyte: fibroblast coupling

Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

FX and host defense evasion tactics by adenovirus

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation

GPR35 as a Novel Therapeutic Target.

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

Identification of peptides that target the endothelial cell-specific LOX-1 receptor.

In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors.

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Novel vectors for in vivo gene delivery to vascular tissue

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts

Prevention of coronary in-stent restenosis and vein graft failure: does vascular gene therapy have a role?

Promoters and control elements: designing expression cassettes for gene therapy.

Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

Simple Methods for Preparing Recombinant Adenoviruses for High-Efficiency Transduction of Vascular Cells

Special focus issue on the annual meeting of the British Society for Gene and Cell Therapy

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors

Targeting gene therapy vectors to the vascular endothelium

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

The frequency of hemochromatosis-associated alleles is increased in British patients with sporadic porphyria cutanea tarda

The frequency of the haemochromatosis-associated genotype D6S265-1:D6S105-8 in blood donors

The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery

The influence of adenovirus fiber structure and function on vector development for gene therapy

The relevance of coagulation factor X protection of adenoviruses in human sera.

Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy

Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

Use of phage display to identify novel peptides for targeted gene therapy

Utilizing proteomics to understand and define hypertension: where are we and where do we go?

Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses

Vector systems for prenatal gene therapy: principles of adenovirus design and production