List of works - Rosa Anna Vacca

3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system.

scientific article

A transient proteasome activation is needed for acetic acid-induced programmed cell death to occur in Saccharomyces cerevisiae.

scientific article published on 19 January 2008

Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome

scientific article published on 01 March 2020

Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase.

scientific article published in August 1997

Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift

scientific article published in 2021

Brain-Immune Alterations and Mitochondrial Dysfunctions in a Mouse Model of Paediatric Autoimmune Disorder Associated with Streptococcus: Exacerbation by Chronic Psychosocial Stress

scientific article published on 20 September 2019

Comparison of the efficacy of gesture-verbal treatment and doll therapy for managing neuropsychiatric symptoms in older patients with dementia

scientific article published on 23 August 2018

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

scientific article published on May 2011

Down syndrome: Neurobiological alterations and therapeutic targets

scientific article published on 04 January 2019

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome

scientific article published on 2 January 2013

Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo.

scientific article published on 23 September 2013

Green tea EGCG plus fish oil omega-3 dietary supplements rescue mitochondrial dysfunctions and are safe in a Down's syndrome child.

scientific article published on 25 April 2015

Helium-Neon laser irradiation of hepatocytes can trigger increase of the mitochondrial membrane potential and can stimulate c-fos expression in a Ca2+-dependent manner.

scientific article

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

scientific article published on October 2010

Import of mutant forms of mitochondrial aspartate aminotransferase into isolated mitochondria

scientific article published on 01 November 1992

In the early phase of programmed cell death in Tobacco Bright Yellow 2 cells the mitochondrial adenine nucleotide translocator, adenylate kinase and nucleoside diphosphate kinase are impaired in a reactive oxygen species-dependent manner

scientific article published on 11 November 2006

Increase in cytosolic and mitochondrial protein synthesis in rat hepatocytes irradiated in vitro by He-Ne laser.

scientific article published on July 1996

Increase of both transcription and translation activities following separate irradiation of the in vitro system components with He-Ne laser.

scientific article published on September 1994

Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.

scientific article

Mitochondria as pharmacological targets in Down syndrome

scientific article

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome.

scientific article published on 15 February 2014

Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1.

scientific article published on 20 February 2015

Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome.

scientific article published on 30 March 2015

Molecular basis of cystic fibrosis in Lithuania: incomplete CFTR mutation detection by PCR-based screening protocols.

scientific article

Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme

scientific article

Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells

scientific article published on 2 August 2013

Novel therapeutic strategies for stroke: The role of autophagy

scientific article published on 01 March 2019

Plant polyphenols as natural drugs for the management of Down syndrome and related disorders

scientific article published on 5 November 2016

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

scientific article published on 14 February 2018

Preservation of mitochondrial functional integrity in mitochondria isolated from small cryopreserved mouse brain areas

scientific article

Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase, and impairment of mitochondrial metabolism are early events in heat shock-induced programmed cell death in tobacco Bright-Yellow 2 cells

scientific article published on March 2004

Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright-Yellow 2 cells

scientific article published on 6 February 2007

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration.

scientific article published on 5 December 2017

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder

article

Serious Games in the new era of digital-health interventions: A narrative review of their therapeutic applications to manage neurobehavior in neurodevelopmental disorders

scientific article published in June 2023

Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome

scientific article

Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders

scientific article published on 20 September 2019

Targeting STATs in neuroinflammation: The road less traveled!

scientific article published on 11 December 2018

Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention.

scientific article published on 23 September 2017

Targeting epigenetics in cancer: therapeutic potential of flavonoids

scientific article published on 01 June 2020

The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome

scientific article published on 01 June 2020

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

scientific article published on 7 March 2016

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols.

scientific article

Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties.

scientific article published in September 2003

Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome.

scientific article

List of works by Rosa Anna Vacca

3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system.

A transient proteasome activation is needed for acetic acid-induced programmed cell death to occur in Saccharomyces cerevisiae.

Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome

Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase.

Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift

Brain-Immune Alterations and Mitochondrial Dysfunctions in a Mouse Model of Paediatric Autoimmune Disorder Associated with Streptococcus: Exacerbation by Chronic Psychosocial Stress

Comparison of the efficacy of gesture-verbal treatment and doll therapy for managing neuropsychiatric symptoms in older patients with dementia

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

Down syndrome: Neurobiological alterations and therapeutic targets

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome

Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo.

Green tea EGCG plus fish oil omega-3 dietary supplements rescue mitochondrial dysfunctions and are safe in a Down's syndrome child.

Helium-Neon laser irradiation of hepatocytes can trigger increase of the mitochondrial membrane potential and can stimulate c-fos expression in a Ca2+-dependent manner.

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

Import of mutant forms of mitochondrial aspartate aminotransferase into isolated mitochondria

In the early phase of programmed cell death in Tobacco Bright Yellow 2 cells the mitochondrial adenine nucleotide translocator, adenylate kinase and nucleoside diphosphate kinase are impaired in a reactive oxygen species-dependent manner

Increase in cytosolic and mitochondrial protein synthesis in rat hepatocytes irradiated in vitro by He-Ne laser.

Increase of both transcription and translation activities following separate irradiation of the in vitro system components with He-Ne laser.

Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.

Mitochondria as pharmacological targets in Down syndrome

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome.

Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1.

Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome.

Molecular basis of cystic fibrosis in Lithuania: incomplete CFTR mutation detection by PCR-based screening protocols.

Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme

Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells

Novel therapeutic strategies for stroke: The role of autophagy

Plant polyphenols as natural drugs for the management of Down syndrome and related disorders

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

Preservation of mitochondrial functional integrity in mitochondria isolated from small cryopreserved mouse brain areas

Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase, and impairment of mitochondrial metabolism are early events in heat shock-induced programmed cell death in tobacco Bright-Yellow 2 cells

Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright-Yellow 2 cells

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration.

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder

Serious Games in the new era of digital-health interventions: A narrative review of their therapeutic applications to manage neurobehavior in neurodevelopmental disorders

Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome

Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders

Targeting STATs in neuroinflammation: The road less traveled!

Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention.

Targeting epigenetics in cancer: therapeutic potential of flavonoids

The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols.

Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties.

Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome.