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List of works by Paavo Honkakoski

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine

scientific article published on 12 October 2016

A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

scientific article published in February 2001

Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines

scientific article published on November 2005

Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy.

scientific article published on 28 November 2007

Amino acids important for ligand specificity of the human constitutive androstane receptor

scientific article

An update on the constitutive androstane receptor (CAR) ⬇️

scientific article published on January 1, 2013

Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

scientific article published in June 1997

Characterization of human cytochrome P450 induction by pesticides.

scientific article published on 28 January 2012

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

scientific article

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

scientific article

Comparative studies on coumarin and testosterone metabolism in mouse and human livers

scientific article published on 01 August 1991

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes

scientific article published on 01 November 1993

Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity

scientific article

Cytochrome P450 isoforms in human fetal tissues related to phenobarbital-inducible forms in the mouse

scientific article published on 01 February 1993

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

scientific article published on 7 November 2017

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

scientific article published on 01 January 2014

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

scientific article

Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes

scientific article published on 01 May 1992

Effects of triaryl phosphates on mouse and human nuclear receptors.

scientific article

Effluxing ABC transporters in human corneal epithelium.

scientific article

Evaluating collaborative planning methods supporting programme-based planning in natural resource management

scientific article published on 28 June 2014

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.

scientific article

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells.

scientific article published on 16 November 2005

Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle

scientific article published on 23 December 2019

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.

scientific article published on February 2016

Highly homologous cytochromes P-450 and b5: a model to study protein-protein interactions in a reconstituted monooxygenase system

article

Human and mouse liver coumarin 7-hydroxylases do not metabolize warfarin in vitro ⬇️

scientific article published on March 1, 1992

Identification of Key Amino Acids that Impact Organic Solute Transporter <i>α</i>/<i>β</i> (OSTα/β)

scientific article published on 01 October 2021

Immunochemical detection of human liver cytochrome P450 forms related to phenobarbital-inducible forms in the mouse

scientific article published on 01 December 1990

Improved assays for xenosensor activation based on reverse transfection

scientific article published on 14 July 2015

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

scientific article published in September 2006

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

scientific article published on 19 April 2016

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

scientific article

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

scientific article published on 12 July 2013

Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.

scientific article published on August 2006

Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.

scientific article published in November 2008

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

scientific article published on 09 August 2006

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

scientific article published on 15 October 2020

Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette-smoking Mothers

article

Molecular Cloning and Characterization of a Novel Nuclear Protein Kinase in Mice ⬇️

scientific article published on April 1, 1998

Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.

scientific article published on October 2003

Molecular dynamics simulations for human CAR inverse agonists.

scientific article published on 25 January 2012

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity

scientific article

Monocarboxylate transport in human corneal epithelium and cell lines.

scientific article

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

article

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

scientific article

Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β)

scientific article published on 14 December 2018

Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

scientific article published on 01 August 2019

Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans

article

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.

scientific article published on 22 February 2014

Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells

scientific article published on 24 January 2019

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

scientific article published on 4 February 2015

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models.

scientific article published on 21 June 2016

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

scientific article

Regulation of gene expression by CAR: an update

scientific article published on 16 May 2015

Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site

scientific article published on 10 January 2012

Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells

article

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.

scientific article published on 7 April 2010

Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library

scientific article

The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 (ALDH1A7) Gene Expression

scientific article published on 01 October 2019

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

scientific article published on 24 April 2020

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system ⬇️

scientific article published on March 18, 2012

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells.

scientific article published on 9 January 2017

Use of comprehensive screening methods to detect selective human CAR activators.

scientific article

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