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List of works by Nicolas Ruggli

A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration

scientific article

A Polyuridine Insertion in the 3' Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets

scientific article published on 06 January 2020

A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells

scientific article published on 08 January 2019

A cloned classical swine fever virus derived from the vaccine strain GPE- causes cytopathic effect in CPK-NS cells via type-I interferon-dependent necroptosis

scientific article published on 09 November 2019

An improved method for cloning PCR fragments

scientific article published on 01 August 1992

Antigenic characterization of recombinant hemagglutinin proteins derived from different avian influenza virus subtypes

scientific article

Antiviral activity of K22 against members of the order Nidovirales.

scientific article published on 11 January 2018

Approaches to define the viral genetic basis of classical swine fever virus virulence

scientific article

Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro

scientific article published on 19 February 2014

Baculovirus expression and affinity purification of protein E2 of classical swine fever virus strain Alfort/187.

scientific article published on January 1995

Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences.

scientific article

Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.

scientific article

Classical Swine Fever Virus Can Remain Virulent after Specific Elimination of the Interferon Regulatory Factor 3-Degrading Function of Npro

scientific article (publication date: 2009)

Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of Npro

scientific article (publication date: July 2003)

Classical Swine Fever Virus Npro Interacts with Interferon Regulatory Factor 3 and Induces Its Proteasomal Degradation

scientific article (publication date: April 2007)

Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7.

scientific article

Classical swine fever virus leader proteinase Npro is not required for viral replication in cell culture

scientific article

Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application.

scientific article published on 17 June 2006

Clustering of classical swine fever virus isolates by codon pair bias ⬇️

scientific article published on November 29, 2011

Correction: Efficient Sensing of Infected Cells in Absence of Virus Particles by Plasmacytoid Dendritic Cells Is Blocked by the Viral Ribonuclease Erns

scientific article published on 6 August 2013

Dendritic cells--at the front-line of pathogen attack

scientific article published on 17 October 2008

Detection of antibodies against classical swine fever virus in swine sera by indirect ELISA using recombinant envelope glycoprotein E2.

scientific article published on July 1996

Efficacy and functionality of lipoprotein OprI from Pseudomonas aeruginosa as adjuvant for a subunit vaccine against classical swine fever.

scientific article

Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs

scientific article published on 9 July 2015

Efficient sensing of infected cells in absence of virus particles by plasmacytoid dendritic cells is blocked by the viral ribonuclease E(rns.).

scientific article

Establishment of an in vitro system for the prediction of the degree of virulence of classical swine fever virus isolates.

scientific article published on January 2007

Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease

scientific article

Experimental pigeon paramyxovirus-1 infection in chicken: evaluation of infectivity, clinical and pathological manifestations and diagnostic methods

scientific article published on 10 January 2020

Fibrocytes are potent stimulators of anti-virus cytotoxic T cells

scientific article published on 14 March 2005

Functional RNA delivery targeted to dendritic cells by synthetic nanoparticles.

scientific article published on September 2012

Functional cDNA clones of the Flaviviridae: strategies and applications.

scientific article

Hemagglutinin-dependent tropism of H5N1 avian influenza virus for human endothelial cells.

scientific article published on 07 October 2009

Heterogeneous antigenic properties of the porcine reproductive and respiratory syndrome virus nucleocapsid

scientific article

High IFN-alpha responses associated with depletion of lymphocytes and natural IFN-producing cells during classical swine fever.

scientific article

High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chicken

scientific article

Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex

scientific article published on 9 January 2012

Highly pathogenic avian influenza viruses do not inhibit interferon synthesis in infected chickens but can override the interferon-induced antiviral state

scientific article

Identification of classical swine fever virus protein E2 as a target for cytotoxic T cells by using mRNA-transfected antigen-presenting cells.

scientific article published on September 2005

Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference

scientific article published on 22 April 2011

Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy

scientific article

Immunogenic and replicative properties of classical swine fever virus replicon particles modified to induce IFN-α/β and carry foreign genes

scientific article published on 22 December 2010

In-yeast reconstruction of the African swine fever virus genome isolated from clinical samples

scientific article published on 08 September 2021

Infectious Bovine Viral Diarrhea Virus (Strain NADL) RNA from Stable cDNA Clones: a Cellular Insert Determines NS3 Production and Viral Cytopathogenicity ⬇️

scientific article published on June 1, 1998

Intracellular membrane association of the N-terminal domain of classical swine fever virus NS4B determines viral genome replication and virulence

scientific article published on 26 May 2015

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model

scientific article

MDA5 can be exploited as efficacious genetic adjuvant for DNA vaccination against lethal H5N1 influenza virus infection in chickens

scientific article

Mycoplasma contamination and viral immunomodulatory activity: dendritic cells open Pandora's box.

scientific article

N(pro) of classical swine fever virus prevents type I interferon-mediated priming of conventional dendritic cells for enhanced interferon-α response

scientific article published on 7 February 2012

Nonstructural proteins NS2-3 and NS4A of classical swine fever virus: essential features for infectious particle formation.

scientific article published on 4 May 2007

Novel poly-uridine insertion in the 3'UTR and E2 amino acid substitutions in a low virulent classical swine fever virus

scientific article

Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites

scientific article published on 17 April 2014

Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA

scientific article

Oronasal vaccination with classical swine fever virus (CSFV) replicon particles with either partial or complete deletion of the E2 gene induces partial protection against lethal challenge with highly virulent CSFV.

scientific article published on May 2005

PCR: a look behind the scenes at bovine viral diarrhea virus

scientific article published on January 1996

Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer.

scientific article published on 22 June 2016

Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines.

scientific article published on 16 November 2015

Postnatal persistent infection with classical Swine Fever virus and its immunological implications

scientific article published on 4 May 2015

Propagation of classical swine fever virus in vitro circumventing heparan sulfate-adaptation

scientific article published on 14 June 2011

Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens

scientific article published on May 2007

Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity

scientific article published on 17 May 2014

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

scientific article published on 28 July 2021

Responsiveness of fibrocytes to toll-like receptor danger signals

Role of double-stranded RNA and Npro of classical swine fever virus in the activation of monocyte-derived dendritic cells

scientific article published on 8 September 2005

Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B

scientific article

Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids.

scientific article

Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles

scientific article

Self-Replicating RNA Vaccine Delivery to Dendritic Cells.

scientific article published on January 2017

Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure.

scientific article published on 18 September 2017

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

scientific article

Sensing of Porcine Reproductive and Respiratory Syndrome Virus-Infected Macrophages by Plasmacytoid Dendritic Cells

scientific article published on 02 June 2016

The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production.

scientific article

The Structure of Classical Swine Fever Virus Npro: A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction

scientific article

Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets.

scientific article published on March 2007

Virus replicon particle vaccines expressing nucleoprotein of influenza A virus mediate enhanced inflammatory responses in pigs

scientific article published on 27 November 2017

Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs

scientific article published on 19 February 2016

Zinc binding in pestivirus N(pro) is required for interferon regulatory factor 3 interaction and degradation.

scientific article

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