List of works - Abbas Mirshafiey

A Live Vector Expressing HPV16 L1 Generates an Adjuvant-Induced Antibody Response In-vivo

scientific article published on 23 December 2015

A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency

scientific article

A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2)

scientific article published on 01 June 2019

Abnormality of regulatory T cells in common variable immunodeficiency.

scientific article published on 29 December 2016

An in vitro assessment for evaluating the efficiency of β-d-mannuronic acid (M2000) in myelodysplastic syndrome

scientific article published on 10 December 2018

An in vitro evaluation of anti-aging effect of guluronic acid (G2013) based on enzymatic oxidative stress gene expression using healthy individuals PBMCs

scientific article published on 29 March 2017

Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model

scientific article published on 16 February 2017

Anti-aging property of G2013 molecule as a novel immunosuppressive agent on enzymatic and non-enzymatic oxidative stress determinants in Rat model

scientific article published on 24 February 2016

Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model

scientific article published on 21 December 2017

Anti-diabetic effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on insulin production, blood glucose, and inflammatory markers in the experimental diabetes model

scientific article published on 08 June 2018

Anti-inflammatory and anti-tumor effects of α-l-guluronic acid (G2013) on cancer-related inflammation in a murine breast cancer model.

scientific article

Antioxidant therapy in multiple sclerosis.

scientific article published on January 2009

Artemether: a new therapeutic strategy in experimental rheumatoid arthritis.

scientific article published on January 2005

Assessment of immunological profile in ankylosing spondylitis patients following a clinical trial with guluronic acid (G2013), as a new NSAID with immunomodulatory properties

scientific article published on 01 February 2019

Autoimmunity and its association with regulatory T cells and B cell subsets in patients with common variable immunodeficiency.

scientific article

Autoimmunity in Primary Antibody Deficiencies.

scientific article published on 24 December 2016

Autoimmunity in primary T-cell immunodeficiencies.

scientific article

Bee venom, immunostimulant or immunosuppressor? Insight into the effect on matrix metalloproteinases and interferons.

scientific article published on January 2005

Calcium intervention ameliorates experimental model of multiple sclerosis

scientific article published on May 2014

Cellular and molecular mechanisms of immune dysregulation and autoimmunity

scientific article published on 27 August 2016

Combination treatment of docosahexaenoic acid (DHA) and all-trans-retinoic acid (ATRA) inhibit IL-17 and RORγt gene expression in PBMCs of patients with relapsing-remitting multiple sclerosis.

scientific article published on 18 November 2017

Comparison of the Detection Limits of the Culture and PCR Methods for the Detection of Clostridium difficile, Clostridium perfringens, Campylobacter jejuni, and Yersinia enterocolitica in Human Stool

article

Conversion of Calcineurin Inhibitors With Mammalian Target of Rapamycin Inhibitors After Kidney Transplant

scientific article published on February 1, 2013

Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial

scientific article published on 6 May 2014

Dual Effects of Cell Free Supernatants from Lactobacillus acidophilus and Lactobacillus rhamnosus GG in Regulation of MMP-9 by Up-Regulating TIMP-1 and Down-Regulating CD147 in PMADifferentiated THP-1 Cells.

scientific article published on 4 November 2017

EBV and vitamin D status in relapsing-remitting multiple sclerosis patients with a unique cytokine signature.

scientific article published on 13 September 2015

Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial

scientific article published on 26 November 2013

Effect of probiotics on the expression of Barrett's oesophagus biomarkers.

scientific article

Effects of M2000 (D-Mannuronic Acid) on Learning, Memory Retrieval, and Associated Determinants in a Rat Model of Alzheimer's Disease.

scientific article published on 19 December 2016

Effects of guluronic acid (G2013) on SHIP1, SOCS1 induction and related molecules in TLR4 signaling pathway.

scientific article published on 5 January 2018

Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients.

scientific article published on 30 March 2017

Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial

scientific article published on 8 November 2017

Frequency and expression of inhibitory markers of CD4(+) CD25(+) FOXP3(+) regulatory T cells in patients with common variable immunodeficiency.

scientific article

HLA antigens and anti-sperm antibody production in Iranian vasectomized men.

scientific article published in January 2015

Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis

scientific article published on October 2016

IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers

scientific article published on March 2016

IL-22 Produced by T helper Cell 22 as a New player in the Pathogenesis of Immune Thrombocytopenia

scientific article

Identification of occult hepatitis B virus (HBV) infection and viral antigens in healthcare workers who presented low to moderate levels of anti-HBs after HBV vaccination

scientific article

Immunomodulatory and Immunosuppressive Roles of 1α,25(OH)2D3 in Autoimmune Diseases

scientific article published on 29 November 2016

Immunomodulatory effects of M2000 (β-D-Mannuronic acid) on TNF-α, IL-17 and FOXP3 gene expression in patients with inflammatory bowel disease

scientific article

Immunopharmacological effect of β-d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients

scientific article published on 01 November 2019

Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis.

scientific article published on June 2010

Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D3 in Patients with Inflammatory Bowel Diseases

scientific article published on 22 March 2017

Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

scientific article published on 11 February 2012

Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses.

scientific article

International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients

scientific article published on 02 January 2019

Introduction of β-d-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1/COX-2 activity and gene expression.

scientific article published on 25 April 2017

M2000 (β-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway.

scientific article published on 10 December 2016

Natural killer cells and their role in rheumatoid arthritis: friend or foe?

scientific article published in April 2012

New therapeutic approach by G2013 in experimental model of multiple sclerosis.

scientific article published on 12 November 2014

Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis.

scientific article published on 22 February 2018

Pharmacological effects of β-d-mannuronic acid (M2000) on miR-146a, IRAK1, TRAF6 and NF-κB gene expression, as target molecules in inflammatory reactions.

scientific article

Polyunsaturated fatty acids, microflora and colitis

scientific article published on 16 October 2009

Positive and negative effects of prostaglandins in Alzheimer's disease.

scientific article published on 02 September 2013

Preclinical and pharmacotoxicology evaluation of α-l-guluronic acid (G2013) as a non-steroidal anti-inflammatory drug with immunomodulatory property

scientific article published in February 2017

Preclinical assessment ofβ-d-mannuronic acid (M2000) as a non-steroidal anti-inflammatory drug

scientific article published on 01 January 2015

Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental nephritis.

scientific article

Prostaglandins in pathogenesis and treatment of multiple sclerosis

scientific article published on 16 March 2010

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.

scientific article published on 24 July 2010

Regulatory T cells as a therapeutic tool to induce solid-organ transplant tolerance: current clinical experiences.

scientific article published on 30 July 2013

Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis ⬇️

scientific article published on 02 February 2011

Siglec-8 and Siglec-F, the new therapeutic targets in asthma

scientific article published on 11 February 2012

Sodium alginate as a novel therapeutic option in experimental colitis.

scientific article

Soy protein and genistein improves renal antioxidant status in experimental nephrotic syndrome

scientific article

T-Cell Abnormalities in Common Variable Immunodeficiency

scientific article

T-helper 22 cells as a new player in chronic inflammatory skin disorders.

scientific article published on August 2015

TGF-beta as a promising option in the treatment of multiple sclerosis.

scientific article published on 11 March 2009

Targeting of circulating Th17 cells by β-D-mannuronic acid (M2000) as a novel medication in patients with rheumatoid arthritis.

scientific article published on 23 October 2017

Targeting of crosstalk between tumor and tumor microenvironment by β-D mannuronic acid (M2000) in murine breast cancer model.

scientific article published on 17 February 2017

Th1 Cytokine Production Induced by Lactobacillus acidophilus in BALB/c Mice Bearing Transplanted Breast Tumor.

scientific article published on 18 April 2015

Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.

scientific article published on July 2011

The Biology of β-D-mannuronic acid (M2000) on Human Dendritic Cell Based on MicroRNA-155 and MicroRNA-221.

scientific article

The Effect of Lactobacillus acidophilus PTCC 1643 on Cultured Intestinal Epithelial Cells Infected with Salmonella enterica serovar Enteritidis.

scientific article published on 28 February 2017

The Immunomodulatory Effect of Trichophyton Rubrum Exoantigens in the Treatment of Experimental Septic Arthritis.

scientific article

The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis

scientific article published on 08 January 2014

The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease

scientific article

The Safety Property of β-D-Mannuronic Acid (M2000) as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells.

scientific article published on 21 June 2016

The anti-migraine effects of M2000 (β-D-mannuronic acid) on a patient with rheumatoid arthritis; as a case report.

scientific article

The effect of 1, 25(OH)2 D3 (calcitriol) alone and in combination with all-trans retinoic acid on ROR-γt, IL-17, TGF-β, and FOXP3 gene expression in experimental autoimmune encephalomyelitis.

scientific article

The effects of β-D-mannuronic acid (M2000), as a novel NSAID, on COX1 and COX2 activities and gene expression in ankylosing spondylitis patients and the murine monocyte/macrophage, J774 cell line.

scientific article

The imbalance of circulating T helper subsets and regulatory T cells in patients with LRBA deficiency: Correlation with disease severity

scientific article published on 28 May 2018

The neglected role of histamine in Alzheimer's disease.

scientific article published on 15 May 2013

The potent inhibitory effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on anti-cyclic citrullinated peptide antibodies, rheumatoid factor and anti-dsDNA antibodies in patients with rheumatoid arthritis.

scientific article published on 21 March 2017

The potent suppressive effect of β-d-mannuronic acid (M2000) on molecular expression of the TLR/NF-kB Signaling Pathway in ankylosing spondylitis patients

scientific article published on 19 September 2017

The potential role of angiogenic factors in rheumatoid arthritis

scientific article published on 28 January 2014

The potential role of iNKT cells in experimental allergic encephalitis and multiple sclerosis.

scientific article published on 07 March 2014

The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis ⬇️

scientific article published on September 13, 2012

The role of toll-like receptors in B-cell development and immunopathogenesis of common variable immunodeficiency

scientific article

The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients

scientific article published on 29 March 2020

The signal transducer and activator of transcription factors lodge in immunopathogenesis of rheumatoid arthritis

scientific article published on 23 December 2015

Therapeutic effects of D-aspartate in a mouse model of multiple sclerosis

scientific article published on 27 March 2017

Therapeutic effects of dasatinib in mouse model of multiple sclerosis.

scientific article published on 15 May 2015

Tolerability and anti-inflammatory effects of glucuronoxylomannan in collagen-induced arthritis.

scientific article published on September 2004

Treatment of experimental arthritis with M2000, a novel designed non-steroidal anti-inflammatory drug.

scientific article

Treatment of experimental immune complex glomerulonephritis by sodium alginate.

scientific article

Treatment of experimental nephrotic syndrome with artesunate

scientific article published on 01 July 2007

List of works by Abbas Mirshafiey

A Live Vector Expressing HPV16 L1 Generates an Adjuvant-Induced Antibody Response In-vivo

A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency

A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2)

Abnormality of regulatory T cells in common variable immunodeficiency.

An in vitro assessment for evaluating the efficiency of β-d-mannuronic acid (M2000) in myelodysplastic syndrome

An in vitro evaluation of anti-aging effect of guluronic acid (G2013) based on enzymatic oxidative stress gene expression using healthy individuals PBMCs

Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model

Anti-aging property of G2013 molecule as a novel immunosuppressive agent on enzymatic and non-enzymatic oxidative stress determinants in Rat model

Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model

Anti-diabetic effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on insulin production, blood glucose, and inflammatory markers in the experimental diabetes model

Anti-inflammatory and anti-tumor effects of α-l-guluronic acid (G2013) on cancer-related inflammation in a murine breast cancer model.

Antioxidant therapy in multiple sclerosis.

Artemether: a new therapeutic strategy in experimental rheumatoid arthritis.

Assessment of immunological profile in ankylosing spondylitis patients following a clinical trial with guluronic acid (G2013), as a new NSAID with immunomodulatory properties

Autoimmunity and its association with regulatory T cells and B cell subsets in patients with common variable immunodeficiency.

Autoimmunity in Primary Antibody Deficiencies.

Autoimmunity in primary T-cell immunodeficiencies.

Bee venom, immunostimulant or immunosuppressor? Insight into the effect on matrix metalloproteinases and interferons.

Calcium intervention ameliorates experimental model of multiple sclerosis

Cellular and molecular mechanisms of immune dysregulation and autoimmunity

Combination treatment of docosahexaenoic acid (DHA) and all-trans-retinoic acid (ATRA) inhibit IL-17 and RORγt gene expression in PBMCs of patients with relapsing-remitting multiple sclerosis.

Comparison of the Detection Limits of the Culture and PCR Methods for the Detection of Clostridium difficile, Clostridium perfringens, Campylobacter jejuni, and Yersinia enterocolitica in Human Stool

Conversion of Calcineurin Inhibitors With Mammalian Target of Rapamycin Inhibitors After Kidney Transplant

Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial

Dual Effects of Cell Free Supernatants from Lactobacillus acidophilus and Lactobacillus rhamnosus GG in Regulation of MMP-9 by Up-Regulating TIMP-1 and Down-Regulating CD147 in PMADifferentiated THP-1 Cells.

EBV and vitamin D status in relapsing-remitting multiple sclerosis patients with a unique cytokine signature.

Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial

Effect of probiotics on the expression of Barrett's oesophagus biomarkers.

Effects of M2000 (D-Mannuronic Acid) on Learning, Memory Retrieval, and Associated Determinants in a Rat Model of Alzheimer's Disease.

Effects of guluronic acid (G2013) on SHIP1, SOCS1 induction and related molecules in TLR4 signaling pathway.

Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients.

Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial

Frequency and expression of inhibitory markers of CD4(+) CD25(+) FOXP3(+) regulatory T cells in patients with common variable immunodeficiency.

HLA antigens and anti-sperm antibody production in Iranian vasectomized men.

Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis

IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers

IL-22 Produced by T helper Cell 22 as a New player in the Pathogenesis of Immune Thrombocytopenia

Identification of occult hepatitis B virus (HBV) infection and viral antigens in healthcare workers who presented low to moderate levels of anti-HBs after HBV vaccination

Immunomodulatory and Immunosuppressive Roles of 1α,25(OH)2D3 in Autoimmune Diseases

Immunomodulatory effects of M2000 (β-D-Mannuronic acid) on TNF-α, IL-17 and FOXP3 gene expression in patients with inflammatory bowel disease

Immunopharmacological effect of β-d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients

Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis.

Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D3 in Patients with Inflammatory Bowel Diseases

Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses.

International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients

Introduction of β-d-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1/COX-2 activity and gene expression.

M2000 (β-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway.

Natural killer cells and their role in rheumatoid arthritis: friend or foe?

New therapeutic approach by G2013 in experimental model of multiple sclerosis.

Oral administration effects of β-d-mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis.

Pharmacological effects of β-d-mannuronic acid (M2000) on miR-146a, IRAK1, TRAF6 and NF-κB gene expression, as target molecules in inflammatory reactions.

Polyunsaturated fatty acids, microflora and colitis

Positive and negative effects of prostaglandins in Alzheimer's disease.

Preclinical and pharmacotoxicology evaluation of α-l-guluronic acid (G2013) as a non-steroidal anti-inflammatory drug with immunomodulatory property

Preclinical assessment ofβ-d-mannuronic acid (M2000) as a non-steroidal anti-inflammatory drug

Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental nephritis.

Prostaglandins in pathogenesis and treatment of multiple sclerosis

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.

Regulatory T cells as a therapeutic tool to induce solid-organ transplant tolerance: current clinical experiences.

Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis ⬇️

Siglec-8 and Siglec-F, the new therapeutic targets in asthma

Sodium alginate as a novel therapeutic option in experimental colitis.

Soy protein and genistein improves renal antioxidant status in experimental nephrotic syndrome

T-Cell Abnormalities in Common Variable Immunodeficiency

T-helper 22 cells as a new player in chronic inflammatory skin disorders.

TGF-beta as a promising option in the treatment of multiple sclerosis.

Targeting of circulating Th17 cells by β-D-mannuronic acid (M2000) as a novel medication in patients with rheumatoid arthritis.

Targeting of crosstalk between tumor and tumor microenvironment by β-D mannuronic acid (M2000) in murine breast cancer model.

Th1 Cytokine Production Induced by Lactobacillus acidophilus in BALB/c Mice Bearing Transplanted Breast Tumor.

Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.

The Biology of β-D-mannuronic acid (M2000) on Human Dendritic Cell Based on MicroRNA-155 and MicroRNA-221.

The Effect of Lactobacillus acidophilus PTCC 1643 on Cultured Intestinal Epithelial Cells Infected with Salmonella enterica serovar Enteritidis.

The Immunomodulatory Effect of Trichophyton Rubrum Exoantigens in the Treatment of Experimental Septic Arthritis.

The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis

The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease

The Safety Property of β-D-Mannuronic Acid (M2000) as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells.

The anti-migraine effects of M2000 (β-D-mannuronic acid) on a patient with rheumatoid arthritis; as a case report.

The effect of 1, 25(OH)2 D3 (calcitriol) alone and in combination with all-trans retinoic acid on ROR-γt, IL-17, TGF-β, and FOXP3 gene expression in experimental autoimmune encephalomyelitis.