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List of works by Christian Czech

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease

scientific article

A Phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

scientific article published on 16 November 2018

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

scientific article

Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease.

scientific article published in August 1998

Age-associated memory impairment and early Alzheimer's disease. Only time will tell the difference.

scientific article published in March 1995

Alzheimer beta A4-amyloid protein precursor in immunocompetent cells ⬇️

scientific article published on November 25, 1992

Alzheimer dementia and normal aging. Clinical, neuroradiologic, neurophysiologic and molecular biology follow-up data

scientific article published on September 1996

Alzheimer's disease and transgenic mice.

scientific article published in January 1994

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

scientific article published in April 2001

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

scientific article

Amyloid precursor protein (APP) as a microglial acute phase protein

scientific article published on 01 April 1994

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

scientific article

An Objective and Child-friendly Assessment of Arm Function by Using a 3-D Sensor.

scientific article published on 12 February 2018

Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain

scientific article

Apolipoprotein E and Alzheimer dementia. Personal results and brief literature review

scientific article published in November 1994

Apolipoprotein E genotype does not promote the clinical progression of manifest Alzheimer's disease.

scientific article published in March 1996

Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.

scientific article published in January 1994

Apolipoprotein E-epsilon 4 allele and Alzheimer's disease

scientific article

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

scientific article published in January 2005

Biomarker for Spinal Muscular Atrophy: Expression of SMN in Peripheral Blood of SMA Patients and Healthy Controls

scientific article published on 15 October 2015

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets

scientific article published on 23 September 2016

Cerebellar anatomical alterations and attention to eyes in autism

scientific article published on 20 September 2017

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures ⬇️

scientific article published on November 1, 1998

Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease

scientific article

Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase.

scientific article published on May 2007

Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti-NMDA-receptor autoantibody

scientific article

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor

scientific article published on 6 August 2007

Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.

scientific article published on 16 April 2013

Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia.

scientific article published on November 1993

Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results.

scientific article

Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial

scientific article published on 27 April 2018

Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

scientific article published on 5 November 2008

Feasibility of Using Microsoft Kinect to Assess Upper Limb Movement in Type III Spinal Muscular Atrophy Patients.

scientific article

Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.

scientific article published on 27 June 2013

Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis.

scientific article

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

scientific article published in May 1992

Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

scientific article published on 27 June 2017

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

scientific journal article

Impact of Aging: Sporadic, and Genetic Risk Factors on Vulnerability to Apoptosis in Alzheimer's Disease

scientific article published on 01 January 2003

Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice

scientific article published in February 2005

In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia

scientific article published on 28 December 2020

Inhibition of beta A4 production by specific modulation of beta-secretase activity

scientific article

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

scientific article

Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.

scientific article published in July 2002

Laminar specific loss of isocortical presenilin 1 immunoreactivity in Alzheimer's disease. Correlations with the amyloid load and the density of tau-positive neurofibrillary tangles.

scientific article published in April 2000

Longitudinal characterization of biomarkers for spinal muscular atrophy.

scientific article published on 11 April 2017

Metabolite profiling of Alzheimer's disease cerebrospinal fluid

scientific article

Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells

scientific article published on 4 December 2014

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

scientific article

Novel orally active, dibenzazepinone-based gamma-secretase inhibitors

scientific article published on 22 August 2007

Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

scientific article

Overexpression of Rab11 or constitutively active Rab11 does not affect sAPPalpha and Abeta secretions by wild-type and Swedish mutated betaAPP-expressing HEK293 cells.

scientific article published on September 2000

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

scientific article

Patients with autism spectrum disorders display reproducible functional connectivity alterations

scientific article published on 01 February 2019

Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes

scientific article published on 22 July 2012

Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

scientific article published on 23 September 2009

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice ⬇️

scientific article published on July 1, 1997

Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic mice ⬇️

scientific article published on December 28, 2001

Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).

scientific article published on 26 May 2017

Social cognition in autism is associated with the neurodevelopment of the posterior superior temporal sulcus

scientific article

Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis.

scientific article published on 25 October 2014

Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.

scientific article published on 5 November 2007

Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.

scientific article published on 25 September 2013

Targeting Huntingtin Expression in Patients with Huntington’s Disease

scientific article published on 06 May 2019

The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.

scientific article published in October 1998

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

scientific article published on 30 October 2018

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

scientific article

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

scientific article published on 01 November 2003

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