List of works - Luis Alvarez-Vallina

A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts

scientific article published on 12 August 2019

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

scientific article published in Nature Communications

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy

scientific article published on 27 September 2017

Antibody engineering: facing new challenges in cancer therapy.

scientific article

Antibody gene therapy: getting closer to clinical application?

scientific article published on August 2013

Antibody-based antiangiogenic cancer therapy.

scientific article

Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies.

scientific article published on 4 August 2015

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

scientific article

Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis

scientific article

CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors

scientific article

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies

scientific article published on 31 July 2019

Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?

scientific article

Chronic gene delivery of interferon-inducible protein 10 through replication-competent retrovirus vectors suppresses tumor growth.

scientific article published in November 2005

Comment on "Production of multivalent protein binders using a self-trimerization collagen-like peptide scaffold"

scientific article published on 01 October 2008

Corrigendum: Tumor antigen—specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor—modified T cells

scholarly article published in Nature Biotechnology

Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues ⬇️

scientific article published on September 1, 1997

Differential transplantability of human endothelial cells in colorectal cancer and renal cell carcinoma primary xenografts

scientific article published on 10 November 2008

Efficacy and toxicity management of CAR-T-cell immunotherapy: a matter of responsiveness control or tumour-specificity?

scientific article published on April 2016

Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris

scientific article published on 12 August 2014

Engineered human tumor xenografts with functional human vascular networks.

scientific article published on 8 October 2010

Engineering human cells for in vivo secretion of antibody and non-antibody therapeutic proteins

scientific article published on 22 March 2011

Enhanced antiangiogenic therapy with antibody-collagen XVIII NC1 domain fusion proteins engineered to exploit matrix remodeling events.

scientific article published on July 2006

Enhancement of DNA vaccine potency through linkage of antigen to filamentous bacteriophage coat protein III domain I

scientific article published on 01 April 2006

Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system.

scientific article published on 25 March 2010

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications

scientific article published on 23 May 2014

Functional improvement of antibody fragments using a novel phage coat protein III fusion system

scientific article published on 01 November 2002

Functionally fused antibodies--a novel adjuvant fusion system.

scientific article

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

scientific article

Generation and characterization of monospecific and bispecific hexavalent trimerbodies

scientific article published on 5 December 2012

Generation and characterization of recombinant human antibodies specific for native laminin epitopes: potential application in cancer therapy ⬇️

scientific article published on December 1, 2001

Generation of non-permissive basement membranes by anti-laminin antibody fragments produced by matrix-embedded gene-modified cells

scientific article

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

scientific article

Immuno-PET Imaging and Pharmacokinetics of an Anti-CEA scFv-based Trimerbody and Its Monomeric Counterpart in Human Gastric Carcinoma-Bearing Mice

scientific article published on 18 February 2019

Improved stability of multivalent antibodies containing the human collagen XV trimerization domain.

scientific article published on March 2012

In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement.

scientific article published on April 2015

In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences

scientific article

Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells.

scientific article published in July 2003

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

scientific article

Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes

scientific article published on 4 December 2013

Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels

scientific article published on 15 December 2007

Lymphocyte display: a novel antibody selection platform based on T cell activation

scientific article

Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management

scientific article published on 22 October 2014

Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

scientific article

Multivalent antibodies: when design surpasses evolution.

scientific article published on 04 May 2010

Non-hematopoietic stem cells as factories for in vivo therapeutic protein production.

scientific article published on 12 May 2011

Programming controlled adhesion of E. coli to target surfaces, cells, and tumors with synthetic adhesins.

scientific article

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

scientific article

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation

scientific article

Selection of functional human antibodies from retroviral display libraries

scientific article

T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies

scientific article published on 01 March 2019

The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.

scientific article published on 14 December 2011

The coming of age of engineered multivalent antibodies.

scientific article

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications

scientific article published on 01 November 2019

The efficacy versus toxicity profile of combination virotherapy and TLR immunotherapy highlights the danger of administering TLR agonists to oncolytic virus-treated mice

scientific article published on 25 September 2012

The extracellular matrix: a new turn-of-the-screw for anti-angiogenic strategies.

scientific article

The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype

scientific article

The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies

scientific article

The therapeutic potential of engineered human neovessels for cell-based gene therapy ⬇️

scientific article published on November 17, 2010

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

scientific article published on 07 February 2022

Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells.

scientific article published in March 2002

Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.

scientific article published on March 2009

Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy

scientific article published on 01 January 2019

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies.

scientific article

List of works by Luis Alvarez-Vallina

A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy

Antibody engineering: facing new challenges in cancer therapy.

Antibody gene therapy: getting closer to clinical application?

Antibody-based antiangiogenic cancer therapy.

Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies.

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis

CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies

Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?

Chronic gene delivery of interferon-inducible protein 10 through replication-competent retrovirus vectors suppresses tumor growth.

Comment on "Production of multivalent protein binders using a self-trimerization collagen-like peptide scaffold"

Corrigendum: Tumor antigen—specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor—modified T cells

Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues ⬇️

Differential transplantability of human endothelial cells in colorectal cancer and renal cell carcinoma primary xenografts

Efficacy and toxicity management of CAR-T-cell immunotherapy: a matter of responsiveness control or tumour-specificity?

Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris

Engineered human tumor xenografts with functional human vascular networks.

Engineering human cells for in vivo secretion of antibody and non-antibody therapeutic proteins

Enhanced antiangiogenic therapy with antibody-collagen XVIII NC1 domain fusion proteins engineered to exploit matrix remodeling events.

Enhancement of DNA vaccine potency through linkage of antigen to filamentous bacteriophage coat protein III domain I

Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system.

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications

Functional improvement of antibody fragments using a novel phage coat protein III fusion system

Functionally fused antibodies--a novel adjuvant fusion system.

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

Generation and characterization of monospecific and bispecific hexavalent trimerbodies

Generation and characterization of recombinant human antibodies specific for native laminin epitopes: potential application in cancer therapy ⬇️

Generation of non-permissive basement membranes by anti-laminin antibody fragments produced by matrix-embedded gene-modified cells

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

Immuno-PET Imaging and Pharmacokinetics of an Anti-CEA scFv-based Trimerbody and Its Monomeric Counterpart in Human Gastric Carcinoma-Bearing Mice

Improved stability of multivalent antibodies containing the human collagen XV trimerization domain.

In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement.

In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences

Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells.

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes

Long-term in vivo imaging of human angiogenesis: critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels

Lymphocyte display: a novel antibody selection platform based on T cell activation

Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management

Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

Multivalent antibodies: when design surpasses evolution.

Non-hematopoietic stem cells as factories for in vivo therapeutic protein production.

Programming controlled adhesion of E. coli to target surfaces, cells, and tumors with synthetic adhesins.

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation

Selection of functional human antibodies from retroviral display libraries

T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies

The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.

The coming of age of engineered multivalent antibodies.

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications

The efficacy versus toxicity profile of combination virotherapy and TLR immunotherapy highlights the danger of administering TLR agonists to oncolytic virus-treated mice

The extracellular matrix: a new turn-of-the-screw for anti-angiogenic strategies.

The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype

The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies

The therapeutic potential of engineered human neovessels for cell-based gene therapy ⬇️

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells.

Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.

Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies.