List of works - Helen Blanchard

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

scientific article

A crystallographic re-investigation into the structure of Streptomyces griseus proteinase A reveals an acyl-enzyme intermediate

scientific article published on 01 August 1994

Carbohydrate recognition by rotaviruses.

scientific article

Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex

scientific article

Characterisation of oxidized recombinant human galectin-1.

scientific article

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa.

scientific article

Crystallization and preliminary X-ray crystallographic analysis of zebrafish prototype galectin Drgal1-L2.

scientific article

Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV

scientific article published on 23 May 2008

Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8.

scientific article

Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases

article published in 2001

Crystallization and preliminary crystallographic analysis of recombinant human galectin-1.

scientific article published on 24 October 2007

CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins

scientific article

Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein

scientific article

Functional and structural characterization of a heparanase

scientific article

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

scientific article

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment.

scientific article published on December 2012

Galectin-1 inhibitors and their potential therapeutic applications: a patent review

scientific article published on 7 March 2016

Galectin-3 inhibitors: a patent review (2008-present).

scientific article

Galectin-3 interactions with glycosphingolipids

scientific article

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

scientific article

Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*)

scientific article

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors

scientific article published on 22 July 2013

Lactulose as a novel template for anticancer drug development targeting galectins

scientific article published on 01 July 2018

Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development

scientific article published on 27 March 2020

Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.

scientific article published on 20 May 2008

Redox state influence on human galectin-1 function.

scientific article

Relative roles of GM1 ganglioside, N-acylneuraminic acids, and α2β1 integrin in mediating rotavirus infection

scientific article published on 05 February 2014

Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. ⬇️

scientific article

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core

scientific article published on 14 September 2006

Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols

scientific article

Specificity and affinity of neuraminic acid exhibited by canine rotavirus strain K9 carbohydrate-binding domain (VP8*).

scientific article published on 23 April 2018

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

scientific article published on February 2016

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

scientific article

Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes

scientific article published on July 1, 1997

Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8

scientific article published on 10 July 2018

Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8

scientific article published on 21 December 2016

Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection

scientific article

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins

scientific article

Taloside inhibitors of galectin-1 and galectin-3

scientific article

The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

scientific journal article

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.

scientific article

List of works by Helen Blanchard

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

A crystallographic re-investigation into the structure of Streptomyces griseus proteinase A reveals an acyl-enzyme intermediate

Carbohydrate recognition by rotaviruses.

Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex

Characterisation of oxidized recombinant human galectin-1.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa.

Crystallization and preliminary X-ray crystallographic analysis of zebrafish prototype galectin Drgal1-L2.

Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV

Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8*) of porcine rotavirus strain CRW-8.

Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases

Crystallization and preliminary crystallographic analysis of recombinant human galectin-1.

CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins

Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein

Functional and structural characterization of a heparanase

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment.

Galectin-1 inhibitors and their potential therapeutic applications: a patent review

Galectin-3 inhibitors: a patent review (2008-present).

Galectin-3 interactions with glycosphingolipids

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Insight into host cell carbohydrate-recognition by human and porcine rotavirus from crystal structures of the virion spike associated carbohydrate-binding domain (VP8*)

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors

Lactulose as a novel template for anticancer drug development targeting galectins

Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development

Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.

Redox state influence on human galectin-1 function.

Relative roles of GM1 ganglioside, N-acylneuraminic acids, and α2β1 integrin in mediating rotavirus infection

Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. ⬇️

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core

Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols

Specificity and affinity of neuraminic acid exhibited by canine rotavirus strain K9 carbohydrate-binding domain (VP8*).

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes

Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8

Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8

Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins

Taloside inhibitors of galectin-1 and galectin-3

The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.