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List of works by Christian A. Olsen

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

scientific article published on 20 January 2016

A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

scientific article published on 03 October 2018

Alpha-peptide/beta-peptoid chimeras

scientific article published on 13 March 2007

Aminolysis of Resin-BoundN-Nosylaziridine-2-carboxylic Acids

scientific article published in July 2006

An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM

scientific article published on 13 June 2018

An update on lysine deacylases targeting the expanding "acylome".

scientific article published on 20 December 2013

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

scientific article published on 01 July 2010

Antiplasmodial and Prehemolytic Activities of α-Peptide–β-Peptoid Chimeras

scientific article published on 01 October 2007

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal.

scientific article published on 26 October 2018

Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates

scientific article published on 6 October 2017

Beta-peptoid "foldamers"--why the additional methylene unit?

scientific article published on January 2011

Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides

scientific article

Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities

scientific article published on 31 August 2017

Cis-trans amide bond rotamers in β-peptoids and peptoids: evaluation of stereoelectronic effects in backbone and side chains.

scientific article published on 7 February 2013

Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

scientific article published on 19 January 2022

Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System

scientific article published on 8 November 2016

Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.

scientific article

Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.

scientific article published on March 2009

Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker

scientific article published on 20 August 2018

Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.

scientific article

Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides

scientific article published in December 2009

Effect of Co-inhabiting Coagulase Negative Staphylococci on S. aureus agr Quorum Sensing, Host Factor Binding, and Biofilm Formation

scientific article published on 27 September 2019

Effects of thionation and fluorination on cis-trans isomerization in tertiary amides: an investigation of N-alkylglycine (peptoid) rotamers.

scientific article published on 4 March 2015

Expansion of the Lysine Acylation Landscape ⬇️

scientific article published on February 28, 2012

Expedient protocol for solid-phase synthesis of secondary and tertiary amines

scientific article published on 01 June 2004

Finding the gas pedal on a slow sirtuin

scientific article published on 01 January 2020

Functionalized Helical β-Peptoids

scientific article published on 19 March 2019

Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

scientific article

Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase

scientific article published on 03 May 2018

Identification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation

scientific article published on 22 April 2019

Increasing the Functional Group Diversity in Helical β-Peptoids: Achievement of Solvent- and pH-Dependent Folding

scientific article published on 12 August 2020

Innovative Strategies for Selective Inhibition of Histone Deacetylases

scientific article

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

scientific article published on 9 February 2016

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

scientific article published on 05 August 2019

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

scientific article

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

scientific article

Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.

scientific article

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

scientific article published on 17 October 2017

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

scientific article published on 14 January 2021

Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles

scientific article

Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes

scientific article

Optoepigenetics: An acetylation photoswitch

scientific article published on 14 March 2016

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

scientific article published on 03 November 2020

Peptoid-Peptide hybrid backbone architectures.

scientific article published on January 2010

Photo Cross-Linking Probes Containing ϵ-N-Thioacyllysine and ϵ-N-Acyl-(δ-aza)lysine Residues

scientific article published on 03 March 2020

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR

scientific article

Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

scientific article

Profiling of Substrates for Zinc‐dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro ⬇️

scientific article published on August 13, 2012

Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy

scientific article published in November 2006

Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants

scientific article published on 03 October 2018

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

scientific article

Selectively N-protected enantiopure 2,5-disubstituted piperazines: avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

scientific article

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

scientific article published on 01 April 2005

Solid-phase peptide synthesis and circular dichroism study of chiral beta-peptoid homooligomers

scientific article published on 23 May 2007

Solid-phase polyamine synthesis using piperazine and piperidine building blocks

scientific article published on 01 October 2003

Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers.

scientific article published in September 2004

Structure-Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi

scientific article published on 27 September 2017

Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme ⬇️

scientific article published on May 24, 2012

Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives

scientific article

The effect of various zinc binding groups on inhibition of histone deacetylases 1-11.

scientific article published on 27 December 2013

Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2- epi-Azumamide E and β3-epi-Azumamide E

scientific article published on 05 August 2013

Total synthesis and structural validation of cyclodepsipeptides solonamide A and B

scientific article published in October 2014

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds

scientific article

Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers

scientific article published on 01 March 2006

β-Peptoid Foldamers at Last.

scientific article published on 15 July 2015

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