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List of works by Isabelle Plo

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

scientific article published on 28 December 2016

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy in hamster ovary cells.

scientific article published on 27 April 2009

ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies

scientific article published on 29 October 2015

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

scientific article

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia

scientific article published on 20 July 2009

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

scientific article published on 10 November 2016

Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms

scientific article published on 29 June 2009

Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

scientific article published on 22 September 2004

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle ⬇️

scientific article published on January 23, 2013

CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

scientific article published on 22 July 2016

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

scientific article published on 25 November 2016

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

scientific article published on 25 November 2015

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

scientific article

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

scientific article published on 27 November 2017

DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.

scientific article published on 4 March 2014

Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis

scientific article published on 01 January 1999

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

scientific article published on 01 December 2019

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

scientific article published on 22 June 2020

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution

scientific article published on 12 September 2014

Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem/progenitor cells

scientific article

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

scientific article published on 02 January 2019

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

scientific article published on 27 February 2017

EZH2: a molecular switch of the MPN phenotype

scientific article published on 01 June 2016

Eltrombopag, a potent stimulator of megakaryopoiesis.

scientific article published on December 2016

Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone.

scientific article published on 10 February 2014

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

scientific article published on 12 September 2017

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

scientific article published on 07 January 2014

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

scientific article published on 17 August 2015

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

scientific article published on 12 April 2018

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

scientific article

Identification of MPL R102P Mutation in Hereditary Thrombocytosis.

scientific article published on 20 September 2017

Impact of interferon on a triple positive polycythemia vera

scientific article published on 14 November 2019

Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia

scientific article published on 01 December 2019

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

scientific article

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

scientific article

Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cγ ⬇️

scientific article published on October 11, 2001

Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

scientific article published on August 2002

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

scientific article

Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.

scientific article published on January 2009

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome

scientific article published on 18 June 2018

Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

scientific article published on September 2014

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

scientific article published on 21 December 2017

Not just another kinase mutation!

scientific article published on 01 December 2019

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

scientific article

P53 deletion and NrasG12D cooperate for AML

scientific article published on 01 January 2017

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.

scientific article published on 29 February 2016

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status

scientific article published on 23 August 2016

Phosphatidylcholine‐derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel ⬇️

scientific article published on January 1, 2003

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

scientific article published on 8 October 2015

Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis

scientific article

Quantitative Proteome Heterogeneity in Myeloproliferative Neoplasm Subtypes and Association with JAK2 Mutation Status.

scientific article published on 17 March 2017

Recent advances in understanding myelofibrosis and essential thrombocythemia

scientific article

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

scientific article published on August 2014

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

scientific journal article

TET2 loss, a rescue of JAK2V617F HSCs.

scientific article published in January 2015

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

scientific article published on 24 May 2016

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

scientific article

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

scientific article published on 14 December 2015

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

scientific article published on 26 February 2015

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

scientific article

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

scientific article

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

scientific article

p53 at the crossroads of MPN treatment.

scientific article

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