List of works - Robert G. Salomon

(Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins

scientific article published on 01 December 1997

2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth.

scientific article published on 22 September 2016

4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids

scientific article

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways

scientific article published on 3 November 2016

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells

scientific article published on 09 July 2018

A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA.

scientific article

A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration

scientific article published on 12 March 2010

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.

scientific article published on 26 July 2002

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products.

scientific article published on 14 June 2006

An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine ⬇️

scientific article published on October 31, 2010

An1O2Route to γ-Hydroxyalkenal Phospholipids by Vitamin E-Induced Fragmentation of Hydroperoxydiene-Derived Endoperoxides ⬇️

scientific article published on May 31, 2011

Anhydrolevuglandin D2 inhibits the uterotonic acivity of prostaglandins F2α and D2

scientific article published on 01 January 1988

Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.

scientific article published on 06 February 2009

Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation.

scientific article published on 12 September 2016

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

scientific article (publication date: October 1992)

CEP biomarkers as potential tools for monitoring therapeutics

scientific article (publication date: 2013)

Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.

scientific article published on January 2008

Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

scientific article published on 15 August 2003

Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products

scientific article published on 17 October 2016

Cardiolipin: characterization of distinct oxidized molecular species

scientific article

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

scientific article published on 01 May 2005

Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36

scientific article published on 04 April 2007

Critical Insights into Cardiovascular Disease from Basic Research on the Oxidation of Phospholipids: The γ-Hydroxyalkenal Phospholipid Hypothesis ⬇️

scientific article published on September 30, 2011

Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).

scientific article published on 19 November 2014

Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids

scientific article published on 3 October 2011

Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways.

scientific article

Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

scientific article

Effects of E2 levuglandins on the contractile activity of the rat uterus

scientific article published on 01 July 1987

Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood

scientific article published on 24 June 2016

Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking

scientific article published on 01 August 1990

Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.

scientific article published on 15 October 2012

Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals

scientific article published on 19 April 2007

Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins

scientific article published on 01 January 1995

Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice.

scientific article published on 17 July 2009

Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.

scientific article published on December 2011

Fragmentation of β-Hydroxy Hydroperoxides ⬇️

scientific article published on January 24, 2012

Gamma-hydroxyalkenals are oxidatively cleaved through Michael addition of acylperoxy radicals and fragmentation of intermediate beta-hydroxyperesters.

scientific article published in September 2004

HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques

scientific article published on 01 July 2000

High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.

scientific article

Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells.

scientific article

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

scientific journal article

Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts

scientific article published on 01 May 1999

Identification of oxidatively truncated ethanolamine phospholipids in retina and their generation from polyunsaturated phosphatidylethanolamines

scientific article published in February 2006

Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal

scientific article published on 01 October 1996

Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.

scientific article published on 7 March 2013

Isolevuglandin adducts in disease

scientific article published on 18 February 2015

Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork

scientific article published on 18 December 2007

Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway

scientific article published on 01 May 2000

Isolevuglandin-protein adducts in oxidized low density lipoprotein and human plasma: a strong connection with cardiovascular disease.

scientific article

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1

scientific article

Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo.

scientific article

Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum

scientific article published on 01 December 1999

Levuglandin E2 crosslinks proteins

scientific article published on 01 April 1989

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.

scientific article published on 13 December 2005

Lysophosphatidylcholine is Generated by Spontaneous Deacylation of Oxidized Phospholipids ⬇️

scientific article published on October 25, 2010

Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid

scientific article published on 01 January 1997

Measurement of oxidation in plasma Lp(a) in CAPD patients using a novel ELISA.

scientific article

Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells

scientific article published on 29 June 2016

Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

scientific article published on 6 December 2012

Molecular Structures of Isolevuglandin-Protein Cross-Links.

scientific article published on 7 September 2016

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

scientific article

Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics

scientific article published on June 2008

Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1).

scientific article published in May 2002

Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.

scientific article published on 25 March 2016

Oxidation of low-density lipoproteins produces levuglandin-protein adducts

scientific article published on 01 July 1997

Oxidative damage-induced inflammation initiates age-related macular degeneration.

scientific article published on 27 January 2008

Oxidative fragmentation of hydroxy octadecadienoates generates biologically active gamma-hydroxyalkenals.

scientific article

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

scientific article published on 3 October 2010

Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo

scientific article published on 14 August 2006

Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.

scientific article published in February 2003

Physiological evidence for the possible existence of anhydrolevuglandin E2-like activity in extracts and media from uteri of rats

scientific article published on 01 June 1992

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.

scientific article

Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids

scientific article

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1

scientific article published on 11 March 2013

Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo

scientific article published on 01 July 2006

Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

scientific article published in January 2002

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

scientific article published on 22 August 2013

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

scientific article

Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins

scientific article published on 01 November 1987

Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice

scientific article

Protein adducts of iso[4]levuglandin E2, a product of the isoprostane pathway, in oxidized low density lipoprotein

scientific article published on 01 July 1999

Proteomic and genomic biomarkers for age-related macular degeneration.

scientific article published in January 2010

Pyrrole formation from 4-hydroxynonenal and primary amines

scientific article published on 01 January 1993

Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products

scientific article published on 12 May 2015

Retinal pigment epithelium lipofuscin proteomics.

scientific article published on 24 April 2008

Serum vitamin E and oxidative protein modification in hemodialysis: a randomized clinical trial

scientific article published on 01 August 2007

Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters.

scientific article published on 19 February 2008

Stereospecific total synthesis of prostaglandins via reaction of alpha-alkylcyclopentenones with organocuprates

scientific article published on 01 February 1975

Structural identification and cardiovascular activities of oxidized phospholipids.

scientific article

Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration.

scientific article published on 13 September 2009

Synthesis of thermal reactivity of some 2,3-dioxabicyclo[2.2.1]heptane models of prostaglandin endoperoxides

scientific article published on 01 January 1977

T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration

scientific article

The lipid whisker model of the structure of oxidized cell membranes

scientific article published on 28 November 2007

The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide

scientific article published on 01 January 2012

The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages

scientific article

Total Synthesis Confirms the Molecular Structure Proposed for Oxidized Levuglandin D2.

scientific article published on 14 February 2017

Total syntheses of bioactive oxidized ethanolamine phospholipids

scientific article published on 01 August 2003

Total synthesis of 17-isoLevuglandin E4 and the structure of C22-PGF4alpha

scientific article published on 01 August 2000

Total synthesis of anhydro levug̀landin D2

Total synthesis of oxidized phospholipids. 3. The (11E)-9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine.

scientific article published in October 2000

Total synthesis of prostaglandins. II. Prostaglandin E 1

article by C J Sih et al published 1 May 1972 in Journal of the American Chemical Society

List of works by Robert G. Salomon

(Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins

2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth.

4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells

A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA.

A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products.

An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine ⬇️

An1O2Route to γ-Hydroxyalkenal Phospholipids by Vitamin E-Induced Fragmentation of Hydroperoxydiene-Derived Endoperoxides ⬇️

Anhydrolevuglandin D2 inhibits the uterotonic acivity of prostaglandins F2α and D2

Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.

Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation.

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

CEP biomarkers as potential tools for monitoring therapeutics

Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.

Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products

Cardiolipin: characterization of distinct oxidized molecular species

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36

Critical Insights into Cardiovascular Disease from Basic Research on the Oxidation of Phospholipids: The γ-Hydroxyalkenal Phospholipid Hypothesis ⬇️

Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).

Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids

Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways.

Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

Effects of E2 levuglandins on the contractile activity of the rat uterus

Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood

Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking

Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.

Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals

Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins

Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice.

Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.

Fragmentation of β-Hydroxy Hydroperoxides ⬇️

Gamma-hydroxyalkenals are oxidatively cleaved through Michael addition of acylperoxy radicals and fragmentation of intermediate beta-hydroxyperesters.

HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques

High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.

Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells.

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts

Identification of oxidatively truncated ethanolamine phospholipids in retina and their generation from polyunsaturated phosphatidylethanolamines

Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal

Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.

Isolevuglandin adducts in disease

Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork

Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway

Isolevuglandin-protein adducts in oxidized low density lipoprotein and human plasma: a strong connection with cardiovascular disease.

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1

Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo.

Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum

Levuglandin E2 crosslinks proteins

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.

Lysophosphatidylcholine is Generated by Spontaneous Deacylation of Oxidized Phospholipids ⬇️

Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid

Measurement of oxidation in plasma Lp(a) in CAPD patients using a novel ELISA.

Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells

Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

Molecular Structures of Isolevuglandin-Protein Cross-Links.

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics

Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1).

Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.

Oxidation of low-density lipoproteins produces levuglandin-protein adducts

Oxidative damage-induced inflammation initiates age-related macular degeneration.

Oxidative fragmentation of hydroxy octadecadienoates generates biologically active gamma-hydroxyalkenals.

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo

Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.

Physiological evidence for the possible existence of anhydrolevuglandin E2-like activity in extracts and media from uteri of rats

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.

Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1

Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo

Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins