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List of works by William J. Ray

A complex of iron and nucleic acid catabolites is a signal that triggers differentiation in a freshwater protozoan

scientific article

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

scientific article published on 01 February 2000

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

scientific article published on 18 April 2014

Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.

scientific article published on 21 October 2004

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

scientific article published on October 2007

CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family ⬇️

scientific article (publication date: 25 July 1997)

Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs)

scientific article published on 01 August 2009

Development of a microplate fluorescence assay for kynurenine aminotransferase

scientific article published on 06 November 2010

Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

scientific article

Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators

scientific article published on 20 February 2014

ES cell neural differentiation reveals a substantial number of novel ESTs.

scientific article

Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia

scientific article published on 04 February 2015

Expression of ionotropic glutamate receptor genes by P19 embryonal carcinoma cells.

scientific article published on December 1993

Fused heterocyclic M1 positive allosteric modulators

scientific article published on 16 October 2010

Gene expression analyses in cynomolgus monkeys provides mechanistic insight into high-density lipoprotein-cholesterol reduction by androgens in primates.

scientific article

High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays ⬇️

scientific article published on January 1, 2011

High-throughput screening by RNA interference: control of two distinct types of variance

scientific article

Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators

scientific article published on 10 March 2010

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

scientific article published on 13 January 2014

Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators

scientific article

Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells

scientific article published on 22 February 2014

Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.

scientific article published on 23 October 2003

Induction of Alzheimer’s-like changes in brain of mice expressing mutant APP fed excess methionine ⬇️

scientific article published on December 2, 2010

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

scientific article

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

scientific article published on 30 April 2018

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging

scientific article

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

scientific article published on April 1998

N-heterocyclic derived M1 positive allosteric modulators.

scientific article

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.

scientific article published on 18 March 2008

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

scientific article

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing

scientific article published on 27 February 2015

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

scientific article published in January 2000

Probability of Alzheimer's disease in breast cancer survivors based on gray-matter structural network efficiency

scientific article published in November 2017

Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

scientific article published on 2 December 2009

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

scientific article published on 28 January 2011

Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators

scientific article published on 4 June 2010

Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture.

scientific article published in June 1996

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

scientific article published on 29 May 2007

Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.

scientific article published on 9 February 2006

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.

scientific article published on 24 July 2012

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