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List of works by Michael Welsh

A chimera between platelet-derived growth factor beta-receptor and fibroblast growth factor receptor-1 stimulates pancreatic beta-cell DNA synthesis in the presence of PDGF-BB

scientific article published on 01 January 1992

A role of FRK in regulation of embryonal pancreatic beta cell formation

scientific article published on 25 February 2007

A role of the protein Cbl in FGF-2-induced angiogenesis in murine brain endothelial cells.

scientific article published on 18 April 2005

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

scientific article

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets.

scientific article published in October 2014

Absence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitis

scientific journal article

Adenosine uptake by isolated mouse pancreatic islets

scientific article published on 01 August 1981

Analysis of protein binding to heat shock protein 70 in pancreatic islet cells exposed to elevated temperatures or interleukin 1 beta

scientific article published on 01 May 1991

Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD ⬇️

scientific article published on May 12, 1998

Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb

scientific article

Claes Hellerström and Cartesian diver microrespirometry

scientific article published on 19 November 2015

Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution.

scientific article

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA

scientific article published on 01 November 1985

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability

scientific article published on 01 November 1985

Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia.

scientific article

Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth

scientific journal article

Effects of certain growth factors on in vitro maturation of rat fetal islet-like structures

scientific article published on 01 May 1996

Effects of glucose, leucine and adenosine on insulin release, 45Ca2+ net uptake, NADH/NAD ratios and oxygen consumption of islets isolated from fed and starved mice.

scientific article published on April 1983

Effects of starvation on oxidative metabolism and insulin release by isolated mouse pancreatic islets

scientific article published on 01 October 1982

Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro

scientific article published on 01 February 1997

Efflux of radioactive nucleotides from mouse pancreatic islets prelabelled with 2-3H-adenosine

scientific article published on 01 July 1982

Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells

scientific article published on 01 November 1991

Expression of Protein Tyrosine Kinases in Islet Cells: Possible Role of the Flk-1 Receptor forβ-Cell Maturation from Duct Cells ⬇️

scientific article published on January 1, 1994

GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.

scientific article published on November 2002

GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase.

scientific article published on September 2000

Glucose induced inhibition of radioactive nucleotide efflux from mouse pancreatic islets is dissociated from an increase in islet oxygen uptake

scientific article published on 01 October 1984

Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter

scientific article published on 19 December 2006

Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: implications for tumor angiogenesis

scientific article

Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

scientific article

Impaired glucose homeostasis in Shb-/- mice

scientific article published on 20 August 2009

Interdependent fibroblast growth factor and activin A signaling promotes the expression of endodermal genes in differentiating mouse embryonic stem cells expressing Src Homology 2-domain inactive Shb.

scientific article

Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro

scientific article published on 01 February 1990

Isolation of hsp70-binding proteins from bovine muscle.

scientific article published in July 1991

Leukocyte differentiation by histidine-rich glycoprotein/stanniocalcin-2 complex regulates murine glioma growth through modulation of anti-tumor immunity.

scientific article

Maintenance of hematopoietic stem cell dormancy: yet another role for the macrophage.

scientific article published on 19 September 2016

Mechanism of 3-phenylpyruvate-induced insulin release. Secretory, ionic and oxidative aspects ⬇️

scientific article published on March 15, 1983

Modulation of Src homology 3 proteins by the proline-rich adaptor protein Shb.

scientific article

Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins

scientific article

NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway

scientific article (publication date: 15 September 2000)

Nicotinamide Does Not Protect Islet B-Cell Metabolism Against Alloxan Toxicity ⬇️

scientific article published on October 1, 1984

Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis

scientific article published on 22 May 2020

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation

scientific article published on 11 May 2006

Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization

scientific article (publication date: 15 June 2000)

Pro-tumoral immune cell alterations in wild type and Shb-deficient mice in response to 4T1 breast carcinomas.

scientific article

Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein

scientific article

Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells

scientific article (publication date: 24 September 1999)

Respiration and insulin release in mouse pancreatic islets. Effects of L-leucine and 2-ketoisocaproate in combination with D-glucose and L-glutamine

scientific article published on 01 October 1982

Respiration of the pancreatic B-cell: effects of glucose and 2-aminonorbornane-2-carboxylic acid

scientific article published on 01 January 1980

Role of the Bsk/Iyk non-receptor tyrosine kinase for the control of growth and hormone production in RINm5F cells

scientific article published on 01 January 2000

Role of the Src homology 2 domain-containing protein Shb in murine brain endothelial cell proliferation and differentiation.

scientific article published in March 2002

Role of tyrosine kinase signaling for beta-cell replication and survival.

scientific article

SHB and angiogenic factors promote ES cell differentiation to insulin-producing cells.

scientific article published on 19 April 2006

Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.

scientific article

Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo.

scientific article

Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells

scientific article (publication date: July 2002)

Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero.

scientific article published in September 2007

Shbdeficiency in endothelium but not in leucocytes is responsible for impaired vascular performance during hindlimb ischaemia

scientific article published on 17 January 2015

Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis.

scientific article published on November 2000

Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins

scientific article

Streptozotocin-induced impairment of islet B-cell metabolism and its prevention by a hydroxyl radical scavenger and inhibitors of poly(ADP-ribose) synthetase

scientific article published on 01 November 1983

Structure and evolution of the insulin gene

scientific article published on 01 January 1985

Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

scientific article published on 15 December 2019

The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors

article

The SHB adapter protein is required for efficient multilineage differentiation of mouse embryonic stem cells ⬇️

scientific article published on May 15, 2003

The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells

scientific article

The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells

scientific article

The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity

scientific journal article

The characterization and use of different antibodies against the hsp70 major heat shock protein family for the development of an immunoassay

scientific article published on 01 September 1991

The effects of glibenclamide on rat islet radioactive nucleotide efflux, ATP contents and respiratory rates

scientific article published on 01 October 1983

The platelet-derived growth factor (PDGF) family of tyrosine kinase receptors: a Kit to fix the beta cell?

scientific article

The role of the Src Homology-2 domain containing protein B (SHB) in β cells

scientific article

The stimulus-secretion coupling of amino acid-induced insulin release. Inhibition of islet respiration and insulin release by aminooxyacetate

scientific article published on 01 August 1984

The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine

scientific article published on 01 August 1982

The stimulus-secretion coupling of amino acid-induced insulin release. Secretory and oxidative response of pancreatic islets to L-asparagine

scientific article published on 01 May 1984

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose.

scientific article published on April 1986

Transplantation of transfected pancreatic islets. Stimulation of beta cell DNA synthesis by the src oncogene

scientific article published on 01 January 1994

Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia.

scientific article published in October 2017

VEGFA and tumour angiogenesis.

scientific article published on February 2013

Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency.

scientific article

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts.

scientific article

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