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List of works by Martijn Brugman

Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.

scientific article published on 5 December 2012

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

scientific article

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

scientific article

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

scientific article

Comprehensive Investigation of Parameter Choice in Viral Integration Site Analysis and Its Effects on the Gene Annotations Produced ⬇️

scientific article published on September 27, 2012

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

scientific article published on 24 June 2010

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning

scientific article

Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches ⬇️

scientific article published on August 1, 2012

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

scientific article published in February 2007

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

scientific article published on 17 May 2017

Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples ⬇️

scientific article published on March 14, 2013

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

scientific article published in August 2007

Gene therapy: is IL2RG oncogenic in T-cell development?

scientific article published in September 2006

Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents.

scientific article

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.

scientific article published on 29 December 2005

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

scientific article published on 23 August 2011

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

scientific article published on September 2008

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors

scientific article

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

scientific article

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

scientific article

Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.

scientific article

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

scientific article published on 22 May 2008

Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models.

scientific article published on 7 September 2010

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.

scientific article published on 22 October 2009

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.

scientific article published in September 2013

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations

scientific article published on 27 March 2012

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

scientific article published on 19 January 2011

Resistance of mature T cells to oncogene transformation

scientific article

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

scientific article published on 21 November 2006

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

scientific article

Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance

scientific article

Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.

scientific article

TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression

scientific article published on 10 September 2014

The genomic risk of somatic gene therapy

scientific article published on July 2010

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

scientific article published in August 2007

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development ⬇️

scientific article published on December 15, 2011

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