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List of works by Paul L Ornstein

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

scientific article

(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist

scientific article published on 01 December 1995

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution ⬇️

scientific article published on January 29, 1998

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

scientific article

4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action ⬇️

scientific article published on January 1, 1991

6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists

scientific article published on September 18, 1992

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

scientific article

A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus.

scientific article published in July 2003

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats.

scientific article published on January 1987

Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord

scientific article published on 01 October 1998

Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships

scientific article (publication date: 17 April 1992)

Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures

scientific journal article

Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.

scientific article published on 12 July 2006

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism.

scientific article published on 2 March 2007

CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo

scientific article published on 01 January 1989

Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists

scientific article published on 01 January 1995

Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia.

scientific article published in October 1998

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Act

scientific article published on 6 December 2016

Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.

scientific article published on September 2002

Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes

scientific article published on 01 July 1990

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.

scientific article published on 25 September 2013

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy

scientific article

Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists

scientific article published on 01 February 1998

In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.

scientific article

In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist

scientific article published on 31 December 2015

Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.

scientific article published in January 1998

LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine.

scientific article

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors ⬇️

scientific article published on January 1, 1998

LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia

scientific article published on 01 July 2000

NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal ⬇️

scientific article published on May 2, 1991

Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist

scientific article published on 01 January 1991

Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo

scientific article published on 01 September 2000

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

scientific article published on 11 May 2006

Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid.

scientific article

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.

scientific article published on September 1986

Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives

scientific article published on 11 May 2006

Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.

scientific article published in November 2005

Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives

scientific article published on 02 May 2006

Privileged structure-based ligands for melanocortin receptors-tetrahydroquinolines, indoles, and aminotetralines

scientific article published on 01 October 2005

Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist

scientific article (publication date: October 1992)

Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons.

scientific article published in October 1995

Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490)

scientific article published on 01 January 1996

Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists

scientific article published on 01 March 1999

Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity

scientific article published on 01 May 1996

Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.

scientific article published on July 1998

Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones

scientific article published on 01 September 1992

Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.

scientific article published on April 1989

Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor

scientific article published on 15 November 2005

The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus.

scientific article published in October 1998

The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.

scientific article

Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators

scientific article published on 22 February 2011

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

scientific article published on June 2005

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