List of works by Bart O Williams

(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice

scientific article published on 9 June 2015

A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells

scientific article published on 06 October 2016

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

scientific article

A subset of p53-deficient embryos exhibit exencephaly

scientific article published on 01 June 1995

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

scientific journal article

Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.

scientific article

Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.

scientific article published on 29 August 2014

Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models

scientific article

An osteocalcin-deficient mouse strain without endocrine abnormalities

scientific article published on 28 May 2020

Biomechanical evaluation of fracture fixation constructs using a variable-angle locked periprosthetic femur plate system

scientific article published on 11 March 2014

CRISPR/CAS9 Technologies

scientific article

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

scientific article

Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6.

scientific article published on March 2016

Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

scientific article

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

scientific journal article

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

scientific journal article

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

scientific journal article

Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.

scientific article published on May 2004

Disruption of tubular Flcn expression as a mouse model for renal tumor induction.

scientific article published on 17 June 2015

Fracture healing in mice lacking Pten in osteoblasts: a micro-computed tomography image-based analysis of the mechanical properties of the femur.

scientific article

Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

scientific article published on 01 July 1993

Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis

scientific article published on 28 January 2016

Inactivation of Apc in the mouse prostate causes prostate carcinoma

scientific journal article

Independent validation of experimental results requires timely and unrestricted access to animal models and reagents

scientific article published on 26 June 2020

Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass.

scientific article published on September 2012

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin

scientific article

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

scholarly article

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

scientific article published on 01 April 1998

Loss of Lgals3 Protects Against Gonadectomy-Induced Cortical Bone Loss in Mice

scientific article published on 19 November 2019

Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.

scientific article published on 9 November 2010

Mice with a heterozygous Lrp6 deletion have impaired fracture healing

scientific article published on 06 September 2016

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

scientific article published on 01 October 2007

Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

scientific article published in April 2007

Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.

scientific article published on 17 August 2015

Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.

scientific article

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations

scientific article

Parafibromin inhibits cancer cell growth and causes G1 phase arrest

scientific article

Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice

scientific journal article

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

scientific article published on 17 November 2005

Rad6B is a positive regulator of beta-catenin stabilization

scientific article

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

scientific article published on June 2005

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin

scientific journal article

Regulation of Wnt/β-catenin signaling within and from osteocytes

scientific article

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

scientific article published on 29 May 2011

Response to Wnt Signaling Pathways

scientific article published on 14 September 2015

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

scientific article

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance.

scientific article published on 22 May 2013

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

scientific article

Targeted disruption of p107: functional overlap between p107 and Rb

scientific article published on 01 July 1996

Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy

scientific article

The Rb tumor suppressor is required for stress erythropoiesis.

scientific article published on 30 September 2004

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

scientific journal article

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

scientific journal article

Tumor spectrum analysis in p53-mutant mice

scientific article (publication date: 1994)

Tumor suppression by a severely truncated species of retinoblastoma protein

scientific article

Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53 ⬇️

scientific article published on January 1, 1994

Use of Primary Calvarial Osteoblasts to Evaluate the Function of Wnt Signaling in Osteogenesis

scientific article published on January 2016

Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals

scientific article published in June 2015

Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

scientific article

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

scientific article published on 18 July 2015

Wnt signaling in bone and muscle

scientific article

Wnt signaling, stem cells, and the cellular origin of breast cancer.

scientific article published on June 2007

Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein

scientific article

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells.

scientific article published on 19 April 2011

Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms.

scientific article published on 6 August 2015

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

scientific article

β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!

scientific article

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