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List of works by Vítězslav Bryja

19thActa Physiologicainternational symposium ‘WNT Signaling in Physiology and Disease’- a long way from developmental biology to physiology

A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation

scientific article published on 04 May 2017

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

scientific article

Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator

scientific article published on 07 June 2005

Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled

scientific article published on 07 May 2020

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

scientific article published on February 8, 2011

An efficient method for the derivation of mouse embryonic stem cells.

scientific article published on 9 December 2005

Analysis of binding interfaces of the human scaffold protein AXIN1 by peptide microarrays

scientific article published on 30 August 2018

Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6.

scientific article published on 31 January 2017

Aryl hydrocarbon receptor-activating polychlorinated biphenyls and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells.

scientific article

Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.

scientific article published on 6 July 2015

Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.

scientific article

Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia

scientific article

Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways

scientific article published on 24 October 2008

Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.

scholarly article

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

scientific article

Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia.

scientific article published on 9 January 2018

Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells

scientific article published on 19 August 2016

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

scientific article published on 04 July 2020

Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs

scientific article published on 23 December 2019

Derivation of mouse embryonic stem cells

scientific article published on 01 January 2006

Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts.

scientific article published on October 2002

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

scientific article published on 5 February 2014

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization

scientific article published in Journal of Biological Chemistry

Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner.

scientific article

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

scientific article published on 02 August 2016

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

scientific article published on 18 April 2019

Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia

scientific article published on 9 November 2017

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.

scientific article

Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

scientific article published on 12 October 2008

Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5.

scientific article

Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

scientific article

Genetic interaction between Lrp6 and Wnt5a during mouse development

scientific journal article

High molecular weight FGF2: the biology of a nuclear growth factor.

scientific article published on January 2009

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.

scientific article published on 9 January 2008

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway

scientific article published on 18 March 2014

Increased apoptosis in differentiating p27-deficient mouse embryonic stem cells.

scientific article published in June 2004

Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation.

scientific article

MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus

scientific article published in 2021

Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord.

scientific article

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

scientific article

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

scientific article published on 14 October 2020

N-terminal part of Dishevelled DEP domain is required for Wnt/β-catenin signaling in mammalian cells

scientific article published on 3 July 2017

NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells

scientific article

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.

scientific article published on 9 March 2010

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

scientific article

Post-translational modifications regulate signalling by Ror1.

scientific article published on 27 May 2011

Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells

scientific article published on 11 June 2020

RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer

scientific article published on 10 August 2020

ROR1-based immunomagnetic protocol allows efficient separation of CLL and healthy B cells

scientific article

Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation

scientific article

SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells

scientific journal article

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.

scientific article

Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer.

scientific article published on 31 March 2015

Targeting Casein Kinase 1 (CK1) in Hematological Cancers

scientific article published on 27 November 2020

The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells.

scientific article published on March 2003

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

scientific article published on 25 July 2017

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism

scientific article published on 07 December 2018

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

scientific article published on 28 June 2017

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons

scientific journal article

Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion

scientific journal article

WNT unrelated activities in commercially available preparations of recombinant WNT3a.

scientific article

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.

scientific article published on 8 November 2010

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

scientific article published on 02 April 2019

Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas

scientific article

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

scientific journal article

Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells.

scientific article

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

scientific journal article

Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha.

scientific article published on 18 December 2008

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

scientific journal article

beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

scientific article

β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation

scientific article

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

scientific article published on 21 November 2013