List of works - Mark Isalan

A Comprehensive Network Atlas Reveals That Turing Patterns Are Common but Not Robust

scientific article published on 01 November 2019

A biobrick library for cloning custom eukaryotic plasmids.

scientific article

A cell in a computer

journal article; published in Nature on 2012-08-01

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

scientific article

A shared mechanism of muscle wasting in cancer and Huntington's disease.

scientific article published on 14 December 2015

A split intein T7 RNA polymerase for transcriptional AND-logic.

scientific article published on 27 September 2014

A three-step framework for programming pattern formation.

scientific article

A unified design space of synthetic stripe-forming networks.

scientific article

Accelerated evolution of a minimal 63-amino acid dual transcription factor

scientific article published on 10 June 2020

Advances in zinc finger engineering.

scientific article

An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy

scientific article published on 25 August 2016

Avoiding transcription factor competition at promoter level increases the chances of obtaining oscillation

scientific article

Building synthetic gene circuits from combinatorial libraries: screening and selection strategies.

scientific article

Changes in cardiac nucleotide metabolism in Huntington's disease

scientific article published in December 2016

Commentary: Synthetic Addiction Extends the Productive Life Time of Engineered Escherichia coli Populations.

scientific article published on 12 June 2018

Comprehensive DNA Recognition through Concerted Interactions from Adjacent Zinc Fingers ⬇️

scientific article published on September 1, 1998

Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

scientific article

Construction of semi-randomized gene libraries with weighted oligonucleotide synthesis and PCR.

scientific article

Cooperativity to increase Turing pattern space for synthetic biology

scientific article published on 22 August 2014

Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice

scientific article published on 06 September 2016

Drug-Inducible Control of Lethality Genes: A Low Background Destabilizing Domain Architecture Applied to the Gal4-UAS System in Drosophila.

scientific article

Early transcriptional alteration of histone deacetylases in a murine model of doxorubicin-induced cardiomyopathy

scientific article

Emergent expression of fitness-conferring genes by phenotypic selection

scientific article published in 2022

Engineering of biomolecules by bacteriophage directed evolution.

scientific article published on 22 November 2017

Engineering orthogonal dual transcription factors for multi-input synthetic promoters.

scientific article

Evolvability and hierarchy in rewired bacterial gene networks

scientific article published in April 2008

From noise to synthetic nucleoli: can synthetic biology achieve new insights?

scientific article

Functional Insulator Scanning of CpG Islands to Identify Regulatory Regions of Promoters Using CRISPR.

scientific article published in January 2018

Genetically encoded sender-receiver system in 3D mammalian cell culture

scientific article published on 20 December 2013

Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.

scientific article

Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis.

scientific article published on 16 December 2016

Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes.

scientific article published on October 2004

Intracellular directed evolution of proteins from combinatorial libraries based on conditional phage replication

scientific article published on 10 August 2017

Localized transfection with magnetic beads coated with PCR products and other nucleic acids

scientific article

Neuro-Cardio Mechanisms in Huntington's Disease and Other Neurodegenerative Disorders.

scientific article

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

scientific article

Sender-receiver systems and applying information theory for quantitative synthetic biology

scientific article

Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases

scientific article

Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution

article

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice

scientific article

The PLOS ONE Synthetic Biology Collection: Six Years and Counting ⬇️

scientific article published on August 15, 2012

The propagation of perturbations in rewired bacterial gene networks

scientific article

This title is false.

scientific article published in April 2009

Transcriptional Signature of an Altered Purine Metabolism in the Skeletal Muscle of a Huntington's Disease Mouse Model

scientific article published on 02 March 2017

Trp-ing upon new repressors.

scientific article published on 26 February 2018

Zinc-finger nucleases: how to play two good hands ⬇️

scientific article published on December 28, 2011

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

scientific article

p53 Gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by Solexa sequencing

scientific article

β-catenin fluctuates in mouse ESCs and is essential for Nanog-mediated reprogramming of somatic cells to pluripotency

scientific article published on 4 September 2014

List of works by Mark Isalan

A Comprehensive Network Atlas Reveals That Turing Patterns Are Common but Not Robust

A biobrick library for cloning custom eukaryotic plasmids.

A cell in a computer

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

A shared mechanism of muscle wasting in cancer and Huntington's disease.

A split intein T7 RNA polymerase for transcriptional AND-logic.

A three-step framework for programming pattern formation.

A unified design space of synthetic stripe-forming networks.

Accelerated evolution of a minimal 63-amino acid dual transcription factor

Advances in zinc finger engineering.

An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy

Avoiding transcription factor competition at promoter level increases the chances of obtaining oscillation

Building synthetic gene circuits from combinatorial libraries: screening and selection strategies.

Changes in cardiac nucleotide metabolism in Huntington's disease

Commentary: Synthetic Addiction Extends the Productive Life Time of Engineered Escherichia coli Populations.

Comprehensive DNA Recognition through Concerted Interactions from Adjacent Zinc Fingers ⬇️

Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

Construction of semi-randomized gene libraries with weighted oligonucleotide synthesis and PCR.

Cooperativity to increase Turing pattern space for synthetic biology

Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice

Drug-Inducible Control of Lethality Genes: A Low Background Destabilizing Domain Architecture Applied to the Gal4-UAS System in Drosophila.

Early transcriptional alteration of histone deacetylases in a murine model of doxorubicin-induced cardiomyopathy

Emergent expression of fitness-conferring genes by phenotypic selection

Engineering of biomolecules by bacteriophage directed evolution.

Engineering orthogonal dual transcription factors for multi-input synthetic promoters.

Evolvability and hierarchy in rewired bacterial gene networks

From noise to synthetic nucleoli: can synthetic biology achieve new insights?

Functional Insulator Scanning of CpG Islands to Identify Regulatory Regions of Promoters Using CRISPR.

Genetically encoded sender-receiver system in 3D mammalian cell culture

Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.

Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis.

Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes.

Intracellular directed evolution of proteins from combinatorial libraries based on conditional phage replication

Localized transfection with magnetic beads coated with PCR products and other nucleic acids

Neuro-Cardio Mechanisms in Huntington's Disease and Other Neurodegenerative Disorders.

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

Sender-receiver systems and applying information theory for quantitative synthetic biology

Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases

Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice

The PLOS ONE Synthetic Biology Collection: Six Years and Counting ⬇️

The propagation of perturbations in rewired bacterial gene networks

This title is false.

Transcriptional Signature of an Altered Purine Metabolism in the Skeletal Muscle of a Huntington's Disease Mouse Model

Trp-ing upon new repressors.

Zinc-finger nucleases: how to play two good hands ⬇️

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

p53 Gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by Solexa sequencing

β-catenin fluctuates in mouse ESCs and is essential for Nanog-mediated reprogramming of somatic cells to pluripotency