List of works - Steven Bozinovski

A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD.

scientific article published on 5 September 2007

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

scientific article published on 01 April 2019

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

scientific article

Acquired somatic mutations in the molecular pathogenesis of COPD.

scientific article

Akt in the pathogenesis of COPD.

scientific article published on January 2006

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

scientific article published on 15 February 2016

Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model.

scientific article published on 4 August 2017

COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.

scientific article published on 25 May 2015

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

scientific article

CSF3R/CD114 mediates infection-dependent transition to severe asthma

scientific article published on 09 October 2018

Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity.

scientific article

Cigarette Smoking Exacerbates Skeletal Muscle Injury without Compromising Its Regenerative Capacity

scientific article published on 01 February 2020

Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss.

scientific article published on 10 March 2006

Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells.

scientific article published on September 2004

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response

scientific article published in September 2002

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

scientific article published on 20 January 2012

Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice.

scientific article published on 16 December 2005

Do anti-viral neutrophil responses exacerbate lung inflammation in asthma?

scientific article published on 20 November 2015

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

scientific article published on 01 April 2022

Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice

scientific article

Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease

scientific article

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

scientific article

Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection.

scientific article

Excessive Reactive Oxygen Species Inhibit IL-17A+ γδ T Cells and Innate Cellular Responses to Bacterial Lung Infection

scientific article published on 17 July 2019

Functional relevance of the IL-23-IL-17 axis in lungs in vivo

scientific article published on 01 December 2006

G-CSFR antagonism reduces neutrophilic inflammation during pneumococcal and influenza respiratory infections without compromising clearance

scientific article published on 27 November 2019

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

scientific article

Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD.

scientific article

Glutathione peroxidase-1 as a novel therapeutic target for COPD.

scientific article published on January 2013

Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo

scientific article

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.

scientific article published on 28 May 2010

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation.

scientific article

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo.

scientific article

Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia

scientific article published on 22 February 2017

HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo

scientific article (publication date: 2015)

Harnessing the potential of lung stem cells for regenerative medicine.

scientific article

House Dust Mite Aeroallergen Suppresses Leukocyte Phagocytosis and Netosis Initiated by Pneumococcal Lung Infection

scientific article published on 22 February 2022

IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo--effects of anti-inflammatory pharmacotherapy

scientific article published on 24 December 2008

IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells

scientific article

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice.

scientific article published on 10 February 2014

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis

scientific article published on 23 December 2014

Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space

scientific article published on 16 April 2008

Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects

scientific article

Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways.

scientific article published on April 2004

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice.

scientific article

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice.

scientific article published on 4 February 2011

Mitochondrial Reactive Oxygen Species Contribute to Pathological Inflammation During Influenza A Virus Infection in Mice

scientific article published on 12 July 2019

Modelling COPD co-morbidities in preclinical models

article

Modelling COPD in mice.

scientific article

Multifaceted Role for IL-17A in the Pathogenesis of Chronic Obstructive Pulmonary Disease

scientific article published on 01 June 2015

Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice

scientific article published on 4 March 2016

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

scientific article published in July 2010

New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease

scientific article published on 12 April 2019

Novel multiplex droplet digital PCR assay for scoring PD-L1 in non-small cell lung cancer biopsy specimens

scientific article published on 02 July 2019

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.

scientific article

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

scientific article published on 26 February 2019

Preclinical murine models of Chronic Obstructive Pulmonary Disease.

scientific article published on 24 March 2015

Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice.

scientific article published in January 2018

Recent advances in pre-clinical mouse models of COPD.

scientific article published on February 2014

Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.

scientific article published on 5 December 2017

Regulation of hypothalamic NPY by diet and smoking.

scientific article published on 17 January 2007

Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review

article

Role of alveolar macrophages in chronic obstructive pulmonary disease.

scientific article

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

scientific article published in January 2005

SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling

scientific article

Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes

scientific article published on 19 January 2016

Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

scientific article published on 3 January 2012

Serum amyloid A promotes lung neutrophilia by increasing IL-17A levels in the mucosa and γδ T cells.

scientific article published on July 2013

Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease

scientific article

TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.

scientific article

Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities

scientific article

Targeting pro-resolution pathways to combat chronic inflammation in COPD

scientific article

The Akt kinase signals directly to endothelial nitric oxide synthase

scientific journal article

The transcriptomic response of Streptococcus pneumoniae following exposure to cigarette smoke extract

scientific article published in Scientific Reports

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

scientific article published on 2 July 2016

Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF).

scientific article

Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways.

scientific article published on 21 July 2013

Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment.

scientific article published on 15 February 2017

Unaltered TNF-alpha production by macrophages and monocytes in diet-induced obesity in the rat.

scientific article

List of works by Steven Bozinovski

A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD.

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

Acquired somatic mutations in the molecular pathogenesis of COPD.

Akt in the pathogenesis of COPD.

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model.

COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

CSF3R/CD114 mediates infection-dependent transition to severe asthma

Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity.

Cigarette Smoking Exacerbates Skeletal Muscle Injury without Compromising Its Regenerative Capacity

Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss.

Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells.

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice.

Do anti-viral neutrophil responses exacerbate lung inflammation in asthma?

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice

Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection.

Excessive Reactive Oxygen Species Inhibit IL-17A+ γδ T Cells and Innate Cellular Responses to Bacterial Lung Infection

Functional relevance of the IL-23-IL-17 axis in lungs in vivo

G-CSFR antagonism reduces neutrophilic inflammation during pneumococcal and influenza respiratory infections without compromising clearance

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD.

Glutathione peroxidase-1 as a novel therapeutic target for COPD.

Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation.

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo.

Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia

HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo

Harnessing the potential of lung stem cells for regenerative medicine.

House Dust Mite Aeroallergen Suppresses Leukocyte Phagocytosis and Netosis Initiated by Pneumococcal Lung Infection

IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo--effects of anti-inflammatory pharmacotherapy

IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice.

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis

Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space

Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects

Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways.

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice.

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice.

Mitochondrial Reactive Oxygen Species Contribute to Pathological Inflammation During Influenza A Virus Infection in Mice

Modelling COPD co-morbidities in preclinical models

Modelling COPD in mice.

Multifaceted Role for IL-17A in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease

Novel multiplex droplet digital PCR assay for scoring PD-L1 in non-small cell lung cancer biopsy specimens

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Preclinical murine models of Chronic Obstructive Pulmonary Disease.

Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice.

Recent advances in pre-clinical mouse models of COPD.

Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.

Regulation of hypothalamic NPY by diet and smoking.

Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review

Role of alveolar macrophages in chronic obstructive pulmonary disease.

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling

Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes

Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

Serum amyloid A promotes lung neutrophilia by increasing IL-17A levels in the mucosa and γδ T cells.

Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease

TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.

Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities

Targeting pro-resolution pathways to combat chronic inflammation in COPD

The Akt kinase signals directly to endothelial nitric oxide synthase

The transcriptomic response of Streptococcus pneumoniae following exposure to cigarette smoke extract

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF).

Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways.

Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment.

Unaltered TNF-alpha production by macrophages and monocytes in diet-induced obesity in the rat.