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List of works by Chris P. Guise

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells

scientific article

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

scientific article

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

scientific article published on 16 April 2014

DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.

scientific article

Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia

scientific article published on 7 October 2011

Efficacy against subcutaneous or intracranial murine GL261 gliomas in relation to the concentration of the vascular-disrupting agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), in the brain and plasma

scientific article published on 30 January 2014

FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells

scientific article

Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum

scientific article

Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5

scientific article published on 15 August 2014

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

scientific article

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

scientific article

Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.

scientific article

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

scientific article published on 10 June 2013

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

scientific article

Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice.

scientific article

Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.

scientific article

Synthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditions.

scientific article published in December 2013

The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104.

scientific article published on 07 October 2013

The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3

scientific article

Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence

scientific article

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