List of works - Frédéric Darios

Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

scientific journal article

Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia

scientific article

Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia

scientific article published on 06 June 2013

Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia

scientific article

Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study

scientific article

CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56.

scientific article published on 16 October 2017

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia

scientific article

Emerging evidence for the modulation of exocytosis by signalling lipids

scientific article published on 10 July 2018

Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan

scientific article published on 7 September 2016

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease

scientific article published on 17 June 2015

Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia

scientific article

Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration

scientific article

Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis

scientific article published on 17 October 2019

Mechanism of arachidonic acid action on syntaxin-Munc18.

scientific article published on 16 March 2007

Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death

scientific article published on 01 October 2000

Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation

scientific article published on 22 December 2016

Motor neuron degeneration in spastic paraplegia 11 mimics amyotrophic lateral sclerosis lesions

scientific article published on 25 March 2016

N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody.

scientific article published in October 2009

Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.

scientific article

Noradrenaline provides long-term protection to dopaminergic neurons by reducing oxidative stress.

scientific article

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

scientific article published on March 2003

Phospholipases and fatty acid signalling in exocytosis.

scientific article published on 21 June 2007

Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination

scientific article published on 01 August 2018

Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell.

scientific article published on December 2005

Regulation of SNARE fusion machinery by fatty acids.

scientific article published on July 2007

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1

scientific article published in 2023

Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion

scientific article published on 20 July 2017

Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis

scientific article published on June 2009

The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism.

scientific article

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission ⬇️

scientific article published on March 11, 2012

[A modular and non pathogenic type A botulinum toxin]

scientific article published on 31 August 2011

List of works by Frédéric Darios

Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia

Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia

Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia

Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study

CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56.

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia

Emerging evidence for the modulation of exocytosis by signalling lipids

Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease

Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia

Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration

Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis

Mechanism of arachidonic acid action on syntaxin-Munc18.

Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death

Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation

Motor neuron degeneration in spastic paraplegia 11 mimics amyotrophic lateral sclerosis lesions

N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody.

Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.

Noradrenaline provides long-term protection to dopaminergic neurons by reducing oxidative stress.

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

Phospholipases and fatty acid signalling in exocytosis.

Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination

Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell.

Regulation of SNARE fusion machinery by fatty acids.

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1

Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion

Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis

The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism.

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission ⬇️

[A modular and non pathogenic type A botulinum toxin]