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List of works by David Bryder

A novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewal

scientific article

A somatic mutation in moesin drives progression into acute myeloid leukemia

scientific article published on 20 April 2022

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging ⬇️

scientific article published on May 6, 2011

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

scientific article

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells

scientific article published on 21 May 2008

Cell intrinsic alterations underlie hematopoietic stem cell aging.

scientific article

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level

scientific article

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

scientific article

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis

scientific article published on 10 November 2003

Concise review: hematopoietic stem cell aging and the prospects for rejuvenation

scientific article

Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.

scientific article published in November 2017

Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials

scientific article published on 01 February 2004

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

scientific journal article

Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion.

scientific article

Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia

scientific article

Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

scientific article published on 19 May 2015

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

scientific article published on 13 June 2018

Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells.

scientific article published in December 1999

Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation

scientific article published on 6 March 2013

EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors.

scientific article published in September 2008

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

scientific article

Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: enhanced reconstitution with gene-marked cells through an ex vivo expansion approach

scientific article published on June 2002

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

scientific article

Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development

scientific article published on 2 August 2007

Flow cytometry-based identification of immature myeloerythroid development.

scientific article

Frequency determination of rare populations by flow cytometry: a hematopoietic stem cell perspective.

scientific article published on 09 July 2013

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

scientific article

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms

scientific article published on 15 February 2017

Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.

scientific article

HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia

scientific article published on 29 September 2014

Hematopoiesis at single-cell resolution

scientific article published on 01 August 2016

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells

scientific article

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells.

scientific article

Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.

scientific article published on 27 April 2009

Hematopoietic stem cell aging: mechanism and consequence.

scientific article

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

scientific article published on November 2009

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

scientific article

Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation

scientific article published on 13 November 2014

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

scientific article published in December 2017

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.

scientific article

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.

scientific article

IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells

scientific article published on 01 January 2005

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

scientific article published in April 2005

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

scientific article

Immunoediting is not a primary transformation event in a murine model of MLL-ENL AML

scientific article published on 10 July 2018

Immunophenotypic Identification of Early Myeloerythroid Development

scientific article published in January 2018

Induced hematopoietic stem cells: unlocking restrictions in lineage potential and self-renewal.

scientific article

Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia

scientific article

Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro.

scientific article published in September 2000

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.

scientific article published in July 2002

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool

scientific journal article

Kit regulates maintenance of quiescent hematopoietic stem cells.

scientific article published in February 2008

Load and lock: the molecular mechanisms of B-lymphocyte commitment.

scientific article

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

scientific article

MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment

scientific article published on 9 January 2017

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia

scientific article

Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis

scientific article

Molecular mechanisms underlying lineage bias in aging hematopoiesis

scientific article published on 20 November 2016

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

scientific article published on 18 December 2018

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

scientific article published on May 2008

Niche recycling through division-independent egress of hematopoietic stem cells

scientific article

Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis.

scientific article published on 23 June 2016

Probing hematopoietic stem cell function using serial transplantation: Seeding characteristics and the impact of stem cell purification

scientific article

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property.

scientific article

Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors.

scientific article published on June 2006

Reduced repression of cytokine signaling ameliorates age‐induced decline in hematopoietic stem cell function ⬇️

scientific article published on August 27, 2012

SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.

scientific article

SCExV: a webtool for the analysis and visualisation of single cell qRT-PCR data

scientific article

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function ⬇️

scientific article published on June 22, 2012

Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

scientific article published on October 2001

Shaping up a lineage--lessons from B lymphopoesis.

scientific article published on 06 March 2010

Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.

scientific article published on 8 December 2009

Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects.

scientific article published in May 2014

The Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells.

scientific article

The slippery slope of hematopoietic stem cell aging

scientific article

The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor

scientific article

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR

scholarly article

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

scientific article published on 18 July 2011

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

scientific article

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