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List of works by Mike-Andrew Westhoff

4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.

scientific article published on 23 November 2007

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

scientific article published on 29 June 2015

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

scientific article published in August 2003

A paired comparison between glioblastoma "stem cells" and differentiated cells

scientific article published on 30 October 2015

Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition

scientific article published on 29 August 2019

Adhesion-mediated apoptosis resistance in cancer

scientific article published on August 2009

Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification

scientific article published on 29 August 2017

Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cells

scientific article published on 19 June 2013

Artesunate enhances the antiproliferative effect of temozolomide on U87MG and A172 glioblastoma cell lines

scientific article published on February 2014

BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.

scientific article published on 18 March 2017

Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity of a low-dose CUSP9 repurposed drug regime against glioblastoma

scientific article published on 30 July 2019

Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach

scientific article published on 3 April 2018

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

scientific article published on March 2017

Cathepsin G-mediated proteolytic degradation of MHC class I molecules to facilitate immune detection of human glioblastoma cells

scientific article published on 2 February 2016

Cell Death Induction in Cancer Therapy - Past, Present, and Future

scientific article published on January 2016

Cell death-based treatment of childhood cancer

scientific article published on 25 January 2018

Cerebral Microstructural Alterations after Radiation Therapy in High-Grade Glioma: A Diffusion Tensor Imaging-Based Study

scientific article

Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma

scientific article published on 15 May 2018

Combined inhibition of HER1/EGFR and RAC1 results in a synergistic antiproliferative effect on established and primary cultured human glioblastoma cells

scientific article published on 5 July 2013

Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis

scientific article published on 11 March 2019

Compare and contrast: pediatric cancer versus adult malignancies

scientific article published on 01 December 2019

Considering the Experimental use of Temozolomide in Glioblastoma Research

scientific article published on 04 June 2020

Current state and future perspective of drug repurposing in malignant glioma

scientific article published on 14 November 2019

Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

scientific article published in Scientific Reports

Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma

scientific article published on 02 March 2020

EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

scientific article published on 01 August 2020

Erlotinib in glioblastoma: lost in translation?

scientific article published on October 2011

Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells

scientific article published on 28 October 2016

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

scientific article published on 03 December 2018

Immune phenotypes predict survival in patients with glioblastoma multiforme.

scientific article

Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma.

scientific article published on 9 May 2018

Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide

scientific article published on 20 June 2019

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems

scientific article published on 10 July 2020

Inhibition of NF-κB signaling ablates the invasive phenotype of glioblastoma

scientific article published on 21 October 2013

Inhibition of PI3K signalling increases the efficiency of radiotherapy in glioblastoma cells

scientific article published on 16 August 2018

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

scientific article published on 10 February 2016

KIT mutations in primary mediastinal B-cell lymphoma.

scientific article published on 22 August 2014

Killing me softly--future challenges in apoptosis research

scientific article

MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma

scientific article published on 06 November 2019

Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma

scientific article published on 23 July 2018

Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.

scientific article published on 15 March 2017

NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.

scientific article published on 7 August 2006

Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

scientific article published on 13 July 2006

Novel Approaches to Apoptosis-Inducing Therapies

scientific article

Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect

scientific article published on 19 December 2014

Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis

scientific article

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

scientific article

RIST: a potent new combination therapy for glioblastoma

scientific article published on September 2014

Radiation and Brain Tumors: An Overview.

scientific article

Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase

scientific article published on November 2005

Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma

scientific article

Simultaneous Interference with HER1/EGFR and RAC1 Signaling Drives Cytostasis and Suppression of Survivin in Human Glioma Cells in Vitro.

scientific article

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

scientific article

TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo

scientific article published on 12 October 2015

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

scientific article published on 09 September 2019

The effects of PI3K-mediated signalling on glioblastoma cell behaviour

scientific article published on 29 November 2017

The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.

scientific article

Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression

scientific article published on 6 November 2013

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids

scientific article published on 21 August 2018

v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.

scientific article published on January 2002

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