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List of works by Neil O Carragher

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

scientific article published in August 2003

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

scientific article published on 19 November 2015

AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins

scientific article

Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue

scientific article published on 28 June 2013

Advancing cancer drug discovery towards more agile development of targeted combination therapies

scientific article

Assaying Calpain Activity

scientific article published on 01 January 2007

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

scientific article published on 27 January 2016

Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

scientific article published on May 2006

Calpain inhibition: a therapeutic strategy targeting multiple disease states.

scientific article

Calpain: a role in cell transformation and migration

scientific article

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery

scientific article published on March 2012

Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment

scientific article

Dasatinib inhibits mammary tumour development in a genetically engineered mouse model

scientific article published on August 2013

Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin

scientific article

Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine

scientific article

Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types

scientific article published on September 2016

Developments in preclinical cancer imaging: innovating the discovery of therapeutics.

scientific article published on 17 April 2014

Empirical drug discovery: a view from the proteome

scientific article published on 01 March 2017

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach.

scientific article

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

scientific article

FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis

scientific article

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

scientific article published on May 2004

Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array

scientific article published on 06 March 2017

High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy

scientific article published on 10 January 2018

High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation

scientific article published on 9 October 2013

High-content phenotypic profiling of drug response signatures across distinct cancer cells

scientific article

Inhibition of NF-κB signaling ablates the invasive phenotype of glioblastoma

scientific article published on 21 October 2013

Inhibition of calpain stabilises podosomes and impairs dendritic cell motility

scientific article (publication date: June 2006)

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies

scientific article published on 15 December 2020

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

scientific article published on 7 June 2013

Live cell in vitro and in vivo imaging applications: accelerating drug discovery

scientific article published on 4 April 2011

MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity

scientific article published on 01 November 2021

Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions

scientific article published in January 2018

Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes

scientific article published in 2022

N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture

scientific article published on 29 July 2014

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin-Targeting Thiazole Analogue of Bisebromoamide

scientific article published on 15 June 2016

Next-generation phenotypic screening

scientific article published on 30 June 2016

Palladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategy

scientific article

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

article

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma

scientific article

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

scientific article published on 18 December 2021

Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action

scientific article

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

scientific article published on 10 July 2015

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

scientific article published on 7 February 2009

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover

scientific article published on 29 October 2008

Quantitative phenotypic and pathway profiling guides rational drug combination strategies

scientific article

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

scientific article

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

scientific article published on 24 March 2009

Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society

scientific article

Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells

scientific article published on 19 July 2013

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Reverse Phase Protein Arrays and Drug Discovery

scientific article published in January 2017

Reverse Phase Protein Arrays elucidate mechanisms-of-action and phenotypic response in 2D and 3D models

scientific article

Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis

scientific article

Screening out irrelevant cell-based models of disease

scientific article published on 12 September 2016

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

scientific article

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ⬇️

scientific article published on 16 October 2017

The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling

scientific article

The calpain system and cancer.

scientific article published on May 2011

The mechanism of cell cycle regulation by v-Src.

scientific article

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

scientific article

v-Src's hold over actin and cell adhesions

scientific article

v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.

scientific article published on January 2002

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