List of works - Grant S Stewart

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

scientific article

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

scientific article

A PIAS-ed view of DNA double strand break repair focuses on SUMO.

scientific article published on March 2010

A nervous predisposition to unrepaired DNA double strand breaks

scientific article published on 17 May 2013

A role for E1B-AP5 in ATR signaling pathways during adenovirus infection

scientific article

A single strand that links multiple neuropathologies in human disease

scientific article published on January 2013

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

scientific journal article

ATM mutations in sporadic lymphoid tumours.

scientific article

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

scientific article published on 12 November 2015

ATRX proximal protein associations boast roles beyond histone deposition

scientific article published on 15 November 2021

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

scientific article published on 5 June 2015

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

scientific article

Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection

scientific article

Alchemix, p53 and topoisomerase

scientific article published on 17 September 2015

Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome

scientific article published on 24 September 2018

Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage

scientific article published on 01 January 2002

Ataxia without telangiectasia revisited: Update on genetic findings in two brothers with an ataxia-telangiectasia-like disorder

scientific article published on 01 July 2001

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.

scientific article

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

scientific article

BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.

scientific article published on 22 July 2014

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

scientific article published on 12 March 2021

Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

scientific article published on 01 March 2022

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

scientific article published on 14 April 2008

DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome

scientific article published on March 2011

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

scientific article published on 07 August 2020

Damaged replication forks tolerate USP7 to maintain genome stability

scientific article published on 6 July 2015

Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1 (Tab182), following adenovirus infection.

scientific article published on 28 March 2018

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

scientific article

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

scientific article published on 21 June 2018

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

scientific article

Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia

scientific article published on 14 February 2019

Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome

scientific article

Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans

Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

article

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus

scientific article

MDC1 is a mediator of the mammalian DNA damage checkpoint

scientific article

MYBL2 supports DNA double strand break repair in haematopoietic stem cells

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.

scientific article

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

scientific article

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

scientific article published on 13 February 2017

Mutations in the NHEJ component XRCC4 cause primordial dwarfism

scientific article published on 5 March 2015

Novel 3q27.2-qter deletion in a patient with Diamond-Blackfan anemia and immunodeficiency: Case report and review of literature.

scientific article published on 21 April 2017

PALB2 variant status in hematological malignancies – a potential therapeutic target?

scientific article published on 07 January 2019

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

scientific article published on 21 February 2018

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

scientific article published on 21 February 2017

Protection or resection: BOD1L as a novel replication fork protection factor

scientific article published on 18 February 2016

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1

scientific article published on 01 March 2022

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

scholarly article

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

scientific article

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

scientific article published on 09 December 2013

Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair

scientific article

Reply: A single strand that links multiple neuropathologies in human disease

scientific article published on 5 August 2013

Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.

scientific article published on 29 May 2001

Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection

scientific article published on 15 December 2010

Solving the RIDDLE of 53BP1 recruitment to sites of damage

scientific article published on 04 May 2009

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

scientific article

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

scientific article published on 3 April 2015

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

scientific article

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

scientific journal article

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

scientific article

The demise of a TUDOR under stress opens a chromatin link to 53BP1

scientific article

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

scientific article published on 18 August 2014

The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells

scientific article

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

scientific article published on 19 November 2012

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

scientific article

USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.

scientific article published on 11 May 2015

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

scientific article

Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination

scientific article

Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias

scientific article published on August 2003

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

scientific article published on 27 August 2020

When cleavage is not attractive: non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1.

scientific article published on 3 December 2010

hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay

scientific article (publication date: 15 May 2001)

p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation

scientific article published on 01 August 2001

List of works by Grant S Stewart

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

A PIAS-ed view of DNA double strand break repair focuses on SUMO.

A nervous predisposition to unrepaired DNA double strand breaks

A role for E1B-AP5 in ATR signaling pathways during adenovirus infection

A single strand that links multiple neuropathologies in human disease

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

ATM mutations in sporadic lymphoid tumours.

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

ATRX proximal protein associations boast roles beyond histone deposition

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection

Alchemix, p53 and topoisomerase

Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome

Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage

Ataxia without telangiectasia revisited: Update on genetic findings in two brothers with an ataxia-telangiectasia-like disorder

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Damaged replication forks tolerate USP7 to maintain genome stability

Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1 (Tab182), following adenovirus infection.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia

Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome

Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans

Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus

MDC1 is a mediator of the mammalian DNA damage checkpoint

MYBL2 supports DNA double strand break repair in haematopoietic stem cells

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

Mutations in the NHEJ component XRCC4 cause primordial dwarfism

Novel 3q27.2-qter deletion in a patient with Diamond-Blackfan anemia and immunodeficiency: Case report and review of literature.

PALB2 variant status in hematological malignancies – a potential therapeutic target?

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

Protection or resection: BOD1L as a novel replication fork protection factor

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair

Reply: A single strand that links multiple neuropathologies in human disease

Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.

Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection

Solving the RIDDLE of 53BP1 recruitment to sites of damage

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

The demise of a TUDOR under stress opens a chromatin link to 53BP1

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination

Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

When cleavage is not attractive: non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1.

hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay

p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation