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List of works by Peter H Willems

A catalytic defect in mitochondrial respiratory chain complex I due to a mutation in NDUFS2 in a patient with Leigh syndrome

scientific article published on 20 October 2011

A conformation-specific interhelical salt bridge in the K+ binding site of gastric H,K-ATPase

scientific article published on 03 February 2004

A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.

scientific article published on 2 November 2012

Action of stimulatory and inhibitory alpha-MSH secretagogues on spontaneous calcium oscillations in melanotrope cells of Xenopus laevis.

scientific article

Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR.

scientific article published on 28 October 2016

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I

scientific article

Amplitude modulation of nuclear Ca2+ signals in human skeletal myotubes: a possible role for nuclear Ca2+ buffering.

scientific article published in August 2005

Asn792 participates in the hydrogen bond network around the K+-binding pocket of gastric H,K-ATPase.

scientific article published on 11 January 2005

Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties

scientific article

Baculovirus complementation restores a novel NDUFAF2 mutation causing complex I deficiency.

scientific article published in July 2009

CCK8-evoked Ca2+ mobilization in pancreatic acinar cells. Evidence for a regulatory role of protein kinase C by phosphorylation-dependent inhibition of signaling through the high-affinity CCK receptor

scientific article published on 01 March 1994

Ca2+ Signals During Early Lymphocyte Activation in Carp Cyprinus Carpio L ⬇️

scientific article published on February 1, 1998

Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency.

scientific article

Cellular and animal models for mitochondrial complex I deficiency: a focus on the NDUFS4 subunit.

scientific article published on 03 February 2013

Chapter 16 The use of fluorescence correlation spectroscopy to probe mitochondrial mobility and intramatrix protein diffusion.

scientific article published in January 2009

Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy

scientific article published on 01 September 1995

Clinical spectrum of the pseudotumor cerebri complex in children

scientific article published on 10 November 2009

Co-ordinated control of apical calcium influx and basolateral calcium efflux in rabbit cortical collecting system

scientific article published on 01 September 1997

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

scientific article published on 23 October 2015

Complex I disorders: causes, mechanisms, and development of treatment strategies at the cellular level.

scientific article published on January 2010

Computer-assisted live cell analysis of mitochondrial membrane potential, morphology and calcium handling.

scientific article published on 16 October 2008

Contiguous gene deletion of ELOVL7, ERCC8 and NDUFAF2 in a patient with a fatal multisystem disorder

article

Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect

scientific article published on 16 March 2017

Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release.

scientific article

Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells

scientific article published on 28 February 2011

Cystine dimethylester model of cystinosis: still reliable?

scientific article published on 01 August 2007

Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases

scientific article

Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly

scientific article

Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts

scientific article

Defective mitochondrial translation differently affects the live cell dynamics of complex I subunits.

scientific article published on 24 September 2011

Determinants for Membrane Association and Permeabilization of the Coxsackievirus 2B Protein and the Identification of the Golgi Complex as the Target Organelle

scientific article published on 18 September 2002

Differences in uptake, storage and release properties between inositol trisphosphate-sensitive and -insensitive Ca2+ stores in permeabilized pancreatic acinar cells

scientific article published on 01 February 1995

Diradylglycerol formation in cholecystokinin-stimulated rabbit pancreatic acini. Assessment of precursor phospholipids by means of molecular species analysis.

scientific article published in January 1996

Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini

scientific article published on 01 October 1990

Dose-dependent recruitment of pancreatic acinar cells during receptor-mediated calcium mobilization ⬇️

scientific article published on February 1, 1993

Effect of protein kinase C activation and down-regulation on active calcium transport

scientific article published on 01 February 1993

Effects of phorbol ester and cholecystokinin on the intracellular distribution of protein kinase C in rabbit pancreatic acini

scientific article published on 01 February 1991

Exploring Levels of Hexosamine Biosynthesis Pathway Intermediates and Protein Kinase C Isoforms in Muscle and Fat Tissue of Zucker Diabetic Fatty Rats ⬇️

scientific article published on April 1, 2003

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.

scientific article published on 30 December 2017

FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia?

scientific article published on 29 October 2009

Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle.

scientific article

Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking.

scientific article published on 23 January 2008

Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome

scientific article (publication date: June 2002)

Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells.

scientific article published on October 2003

G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production.

scientific article published on 8 March 2011

Heterogeneity of intracellular calcium responses to parathyroid hormone and thrombin in primary osteoblast-like cells and UMR106-01 cells: correlations with culture conditions, intracellular calcium concentration and differentiation state

scientific article published on 01 September 1993

Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy

scientific article

Hormonal regulation of phospholipase D activity in Ca(2+) transporting cells of rabbit connecting tubule and cortical collecting duct.

scientific article published in April 2001

Hormone-stimulated Ca2+ reabsorption in rabbit kidney cortical collecting system is cAMP-independent and involves a phorbol ester-insensitive PKC isotype

scientific article published on 01 January 1999

Human Golgi antiapoptotic protein modulates intracellular calcium fluxes

scientific article

Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?

scientific article published on 11 April 2007

Human mitochondrial complex I assembly is mediated by NDUFAF1.

scientific article

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

scientific article

Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia

scientific article published on 17 October 2007

Improvements in fitness are not obligatory for exercise training-induced improvements in CV risk factors

scientific article published in February 2018

Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia.

scientific article

Induction of Ca2+ oscillations by selective, U73122-mediated, depletion of inositol-trisphosphate-sensitive Ca2+ stores in rabbit pancreatic acinar cells.

scientific article

Inherited complex I deficiency is associated with faster protein diffusion in the matrix of moving mitochondria.

scientific article

Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth.

scientific article

Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.

scientific article

Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.

scientific article published on 17 April 2003

Inhibitory and stimulatory interactions between endogenous gonadotropin-releasing hormones in the African catfish (Clarias gariepinus)

scientific article published on 01 March 2000

Integrated High-Content Quantification of Intracellular ROS Levels and Mitochondrial Morphofunction

scientific article published on January 2016

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism.

scientific article published on 6 June 2015

Isoflurane anesthetic hypersensitivity and progressive respiratory depression in a mouse model with isolated mitochondrial complex I deficiency.

scientific article published on 13 February 2014

Life cell quantification of mitochondrial membrane potential at the single organelle level.

scientific article

Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story.

scientific article published in August 2004

Live-cell assessment of mitochondrial reactive oxygen species using dihydroethidine.

scientific article

Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation.

scientific article published on June 2010

Metabolic consequences of NDUFS4 gene deletion in immortalized mouse embryonic fibroblasts.

scientific article

Mimicking of K+ activation by double mutation of glutamate 795 and glutamate 820 of gastric H+,K+-ATPase.

scientific article published on May 2001

Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment.

scientific article published on 8 April 2008

Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity

scientific article

Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency.

scientific article published on 04 March 2008

Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency.

scientific article published on 25 May 2007

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease.

scientific article published on 31 March 2009

Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity

scientific article published on 28 September 2011

Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics

scientific article published on 07 February 2015

Mitochondrial dynamics in human NADH:ubiquinone oxidoreductase deficiency.

scientific article published on 28 January 2009

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α.

scientific article published on 20 December 2014

Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V.

scientific article

Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency.

scientific article published on 18 May 2005

Mitochondrial processes are impaired in hereditary inclusion body myopathy.

scientific article published on 23 August 2008

Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux.

scientific article published on October 2015

Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells.

scientific article

Monogenic Mitochondrial Disorders ⬇️

scientific article published on March 22, 2012

Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency.

scientific article published on 27 January 2010

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

scientific article

Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication.

scientific article published on 18 February 2004

Mutational analysis of the potential phosphorylation sites for protein kinase C on the CCK(A) receptor

scientific article

Mutational analysis of the putative devazepide binding site of the CCKA receptor

scientific article published on 01 April 1997

Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease

scientific article

NDUFA2 complex I mutation leads to Leigh disease

scientific article

Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells.

scientific article published in July 2002

Neuropeptide Y inhibits Ca2+ oscillations, cyclic AMP, and secretion in melanotrope cells of Xenopus laevis via a Y1 receptor.

scientific article published on January 1995

OXPHOS mutations and neurodegeneration

scientific article published on 13 November 2012

Oxidized low-density lipoprotein induces calcium influx in polymorphonuclear leukocytes

scientific article published on 01 October 2000

PKC-mediated inhibitory feedback of the cholecystokinin 1 receptor controls the shape of oscillatory Ca²⁺ signals

scientific article published on 13 April 2015

Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor

scientific article published on 25 October 2008

Partial complex I inhibition decreases mitochondrial motility and increases matrix protein diffusion as revealed by fluorescence correlation spectroscopy.

scientific article published on 6 April 2007

Patient-derived fibroblasts indicate oxidative stress status and may justify antioxidant therapy in OXPHOS disorders.

scientific article

Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.

scientific article published on April 1987

Pharmacological targeting of mitochondrial complex I deficiency: the cellular level and beyond.

scientific article published on 02 July 2011

Phe783, Thr797, and Asp804 in transmembrane hairpin M5-M6 of Na+,K+-ATPase play a key role in ouabain binding.

scientific article published on 12 September 2003

Phenotypic knock out of heparan sulfates in myotubes impairs excitation-induced calcium spiking.

scientific article

Phorbol ester inhibits cholecystokinin octapeptide-induced amylase secretion and calcium mobilization, but is without effect on secretagogue-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in rabbit pancreatic acini

scientific article published on 01 September 1987

Phosphorylation and Desensitization of the Pancreatic Cholecystokinin-A Receptor ⬇️

scientific article published on January 1, 1997

Photo-induction and automated quantification of reversible mitochondrial permeability transition pore opening in primary mouse myotubes

scientific article

Phytanic acid impairs mitochondrial respiration through protonophoric action.

scientific article published in December 2007

Potentiating role of cyclic AMP in pancreatic enzyme secretion, demonstrated by means of forskolin

scientific article published on 01 November 1984

Protein kinase C-mediated inhibition of transmembrane signalling through CCK(A) and CCK(B) receptors

scientific article

Purification and isotype analysis of protein kinase C from rat liver nuclei.

scientific article published in February 1998

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.

scientific article published on 26 January 2015

Quantitative Glucose and ATP Sensing in Mammalian Cells ⬇️

scientific article published on June 21, 2011

R-Ras alters Ca2+ homeostasis by increasing the Ca2+ leak across the endoplasmic reticular membrane.

scientific article published on 13 February 2003

Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin ⬇️

scientific article published on September 1, 2001

Receptor-evoked Ca2+ mobilization in pancreatic acinar cells: Evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state ⬇️

scientific article published on July 1, 1993

Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids

scientific article published on 28 July 2005

Recovery from TPA inhibition of receptor-mediated Ca2+ mobilization is paralleled by down-regulation of protein kinase C-alpha in CHO cells expressing the CCK-A receptor.

scientific article

Redox Homeostasis and Mitochondrial Dynamics.

scientific article published on 09 July 2015

Reduced cholecystokinin receptor phosphorylation and restored signalling in protein kinase C down-regulated rat pancreatic acinar cells.

scientific article published on February 1998

Reduction of phospholipase D activity during coxsackievirus infection.

scientific article published on November 2007

Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes.

scientific article published on December 2004

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2.

scientific article published on 28 March 2015

Ruthenium red selectively depletes inositol 1,4,5-trisphosphate-sensitive calcium stores in permeabilized rabbit pancreatic acinar cells ⬇️

scientific article published on 01 August 1993

Skeletal muscle mitochondria of NDUFS4-/- mice display normal maximal pyruvate oxidation and ATP production

scientific article published on 14 February 2015

Solute diffusion is hindered in the mitochondrial matrix

scientific article

Spontaneous calcium oscillations in Xenopus laevis melanotrope cells are mediated by omega-conotoxin sensitive calcium channels.

scientific article published on January 1994

Spontaneous calcium oscillations in melanotrope cells of Xenopus laevis.

scientific article published in May 1993

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

scientific article published on September 2015

Stimulatory and inhibitory effects of TMB-8 on pancreatic enzyme secretion.

scientific article

Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis

scientific article

Superoxide production is inversely related to complex I activity in inherited complex I deficiency.

scientific article published on 4 January 2007

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

scientific article

Synchronized Ca2+ signaling by intercellular propagation of Ca2+ action potentials in NRK fibroblasts ⬇️

scientific article published on December 1, 1997

Synchronized calcium spiking resulting from spontaneous calcium action potentials in monolayers of NRK fibroblasts

scientific article published on 01 September 1997

Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth.

scientific article

The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi

scientific article published on 15 March 2006

The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis.

scientific article published on 19 February 2004

The creatine kinase system is essential for optimal refill of the sarcoplasmic reticulum Ca2+ store in skeletal muscle.

scientific article

The development of the pars intermedia and its role in the regulation of dermal melanophores in the larvae of the amphibian Xenopus laevis ⬇️

scientific article published on July 1, 1984

The diacylglycerol kinase inhibitor, R59022, potentiates cholecystokinin-induced enzyme secretion from rabbit pancreatic acini ⬇️

scientific article published on March 10, 1990

The human non-gastric H,K-ATPase has a different cation specificity than the rat enzyme.

scientific article published on 26 October 2006

The insulin receptor tyrosine kinase domain in a chimaeric epidermal growth factor-insulin receptor generates Ca2+ signals through the PLC-gamma1 pathway

scientific article published on 01 May 1999

The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase.

scientific article published on 7 March 2008

The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase

scientific journal article

The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases ⬇️

scientific article published on 09 March 2012

The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer.

scientific article

Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

scientific article published on 15 September 2017

Time-resolved quantitative analysis of CCK1 receptor-induced intracellular calcium increase.

scientific article published on 23 February 2011

Toward high-content screening of mitochondrial morphology and membrane potential in living cells.

scientific article

Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells.

scientific article published on 13 June 2012

U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells.

scientific article published in April 1998

Upregulation of Ca2+ removal in human skeletal muscle: a possible role for Ca2+-dependent priming of mitochondrial ATP synthesis.

scientific article published on 2 July 2003

Vasopressin-stimulated Ca2+ reabsorption in rabbit cortical collecting system: effects on cAMP and cytosolic Ca2+.

scientific article published on November 1996

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

scientific article

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