List of works - Gavin Chapman

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

scientific article

A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development.

scientific article published on 14 December 2010

A mechanism for gene-environment interaction in the etiology of congenital scoliosis.

scientific article published on 5 April 2012

Cited2 is required in trophoblasts for correct placental capillary patterning

scientific article published on 5 May 2014

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL

scientific article published on 15 August 2011

De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.

scientific article published on 22 September 2017

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

scientific article published on 18 September 2013

Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation.

scientific article published on December 2003

Gene-environment interaction impacts on heart development and embryo survival

scientific article published on 20 February 2019

Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis

scientific article published on 28 December 2010

Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype

scientific article published in January 2006

Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors

scientific article published in 2022

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

scientific article published in August 2017

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

scientific article

Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.

scientific article

Notch signaling in development and disease.

scientific article

Notch1 endocytosis is induced by ligand and is required for signal transduction.

scientific article published on 29 October 2015

Notch4 reveals a novel mechanism regulating Notch signal transduction

scientific journal article

Recording Notch signaling in real time.

scientific article published on January 2006

Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene

scientific article published on 01 May 1995

The mouse homeobox gene, Gbx2: genomic organization and expression in pluripotent cells in vitro and in vivo.

scientific article published in December 1997

The mouse notches up another success: understanding the causes of human vertebral malformation.

scientific article published on 11 June 2011

The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease

scientific article published on 13 December 2016

List of works by Gavin Chapman

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development.

A mechanism for gene-environment interaction in the etiology of congenital scoliosis.

Cited2 is required in trophoblasts for correct placental capillary patterning

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL

De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation.

Gene-environment interaction impacts on heart development and embryo survival

Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis

Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype

Myhre syndrome is caused by dominant-negative dysregulation of SMAD4 and other co-factors

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.

Notch signaling in development and disease.

Notch1 endocytosis is induced by ligand and is required for signal transduction.

Notch4 reveals a novel mechanism regulating Notch signal transduction

Recording Notch signaling in real time.

Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene

The mouse homeobox gene, Gbx2: genomic organization and expression in pluripotent cells in vitro and in vivo.

The mouse notches up another success: understanding the causes of human vertebral malformation.

The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease