List of works - Frank S. Lee

A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation

scientific article

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

scientific article

A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

scientific article

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism

scientific article published on 11 October 2013

A novel beta-oxa polyunsaturated fatty acid downregulates the activation of the IkappaB kinase/nuclear factor kappaB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation

scientific article published on 08 June 2006

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

scientific article

A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis

scientific article

A subdomain of MEKK1 that is critical for binding to MKK4

scientific article published on 01 January 2003

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

scientific article

An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23

scientific article published on 13 December 2019

Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing

scientific article

Electronic spectroscopy of cobalt angiotensin converting enzyme and its inhibitor complexes

scientific article published on 01 November 1987

Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation

scientific article published on 02 May 2013

Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline

scientific article

Familial erythrocytosis: molecular links to red blood cell control.

scientific article published in July 2008

Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis.

scientific article published on December 2009

Human high-altitude adaptation: forward genetics meets the HIF pathway.

scientific article

IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity

scientific article

Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.

scientific article

Identification of prolyl hydroxylation modifications in mammalian cell proteins. ⬇️

scientific article published on 19 January 2015

Kinetic characterization of two active mutants of placental ribonuclease inhibitor that lack internal repeats

scientific article published on 01 July 1990

Loss-of-function zinc finger mutation in the EGLN1 gene associated with erythrocytosis

scientific article published on 15 August 2018

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

scientific article (publication date: 26 March 1999)

Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.

scientific article published on March 1990

Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity

scientific article (publication date: 4 April 2003)

Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis: Indications for Distinct Functional Roles of von Hippel-Lindau Tumor Suppressor Isoforms

scientific article published on 29 July 2015

Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway

scientific article published on 14 February 2013

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

scientific article

Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle

scientific article published on 27 October 2020

Subdomain VIII is a specificity-determining region in MEKK1

scientific journal article

The HIF Pathway and Erythrocytosis ⬇️

scientific article published on January 1, 2011

The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.

scientific article published on 20 June 2016

The effect of serum on monolayer cell culture of mammalian articular chondrocytes

scientific article published on 01 January 1980

The role of PHD2 mutations in the pathogenesis of erythrocytosis

scientific article

The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway

scientific article published on 01 April 2003

Tibetan PHD2, an allele with loss-of-function properties

scientific article published on 15 May 2020

Two new mutations in the HIF2A gene associated with erythrocytosis.

scientific article

List of works by Frank S. Lee

A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism

A novel beta-oxa polyunsaturated fatty acid downregulates the activation of the IkappaB kinase/nuclear factor kappaB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis

A subdomain of MEKK1 that is critical for binding to MKK4

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23

Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing

Electronic spectroscopy of cobalt angiotensin converting enzyme and its inhibitor complexes

Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation

Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline

Familial erythrocytosis: molecular links to red blood cell control.

Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis.

Human high-altitude adaptation: forward genetics meets the HIF pathway.

IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity

Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.

Identification of prolyl hydroxylation modifications in mammalian cell proteins. ⬇️

Kinetic characterization of two active mutants of placental ribonuclease inhibitor that lack internal repeats

Loss-of-function zinc finger mutation in the EGLN1 gene associated with erythrocytosis

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.

Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity

Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis: Indications for Distinct Functional Roles of von Hippel-Lindau Tumor Suppressor Isoforms

Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle

Subdomain VIII is a specificity-determining region in MEKK1

The HIF Pathway and Erythrocytosis ⬇️

The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.

The effect of serum on monolayer cell culture of mammalian articular chondrocytes

The role of PHD2 mutations in the pathogenesis of erythrocytosis

The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway

Tibetan PHD2, an allele with loss-of-function properties

Two new mutations in the HIF2A gene associated with erythrocytosis.