List of works - David Wotton

A 3' transcriptional enhancer regulates tissue-specific expression of the human CD2 gene.

scientific article published on October 1990

A CREB1-TGFβ2 self-sustaining loop in glioblastoma

scientific article

A Smad transcriptional corepressor

scientific article (publication date: 2 April 1999)

A phorbol ester response element within the human T-cell receptor beta-chain enhancer ⬇️

scientific article published on October 15, 1992

A rapid strategy to detect the recombined allele in LSL-TβRICA transgenic mice.

scientific article

A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

scientific article

Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis

scientific article

Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor beta gene by protein kinase C, Ras plays multiple roles

scientific article published on 01 August 1993

An autoinhibitory effect of the homothorax domain of Meis2

scientific article

Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene transcription

scientific article published on 01 October 1995

Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors

scientific article published in January 2018

Cooperative binding of Ets-1 and core binding factor to DNA

scientific article published on January 1994

Cooperative transcriptional activation by Klf4, Meis2, and Pbx1

scientific article

Determinants of specificity in TGF-beta signal transduction.

scientific article

Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy

article

Drosophila TGIF proteins are transcriptional activators

scientific article

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly

article

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning

scientific article

Identification and functional analysis of the transcriptional enhancer of the human T cell receptor β gene ⬇️

scientific article published on January 1, 1991

Inhibition of CtBP1 activity by Akt-mediated phosphorylation

scientific article

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway

scientific article

Maternal Tgif is required for vascularization of the embryonic placenta

scientific article

Multimerization of Hsp42p, a novel heat shock protein of Saccharomyces cerevisiae, is dependent on a conserved carboxyl-terminal sequence.

scientific article

Multiple activities contribute to Pc2 E3 function

scientific article

Multiple modes of repression by the Smad transcriptional corepressor TGIF

scientific article published on 01 December 1999

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

scientific article (publication date: June 2000)

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 ⬇️

scientific article published on July 3, 1997

Pc2 and SUMOylation

scientific article

Premature senescence and increased TGFβ signaling in the absence of Tgif1.

scientific article

Prostate cancer induced by loss of Apc is restrained by TGFβ signaling

scientific article

Rap1p and telomere length regulation in yeast.

scientific article published on January 1997

Regulation of human T cell receptor beta gene expression by Ets-1.

scientific article

SUMO and Chromatin Remodeling

scientific article

Smad transcriptional corepressors in TGF beta family signaling.

scientific article

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition.

scientific article published on 15 March 2018

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.

scientific article

TGF-β drives DNA demethylation

scientific article

TGFβ signaling limits lineage plasticity in prostate cancer.

scientific article

TGIF inhibits retinoid signaling

scientific article

TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth

scientific article published on 26 February 2019

TGIF2 interacts with histone deacetylase 1 and represses transcription

scientific article (publication date: 24 August 2001)

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse

scientific article

Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l

scientific article

Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation

scientific article

Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells

scientific article

Tgif1 represses apolipoprotein gene expression in liver

scientific article

The Runx3 distal transcript encodes an additional transcriptional activation domain

scientific journal article

The Smad transcriptional corepressor TGIF recruits mSin3

scientific article (publication date: September 2001)

The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila

scientific article

The Tgif2 gene contains a retained intron within the coding sequence

scientific article

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF

scientific article (publication date: 15 December 2000)

The polycomb protein Pc2 is a SUMO E3

scientific journal article

The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression

scientific article published on 6 September 2017

Transcriptional control by the TGF-beta/Smad signaling system

scientific article (publication date: 17 April 2000)

dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2.

scientific article

List of works by David Wotton

A 3' transcriptional enhancer regulates tissue-specific expression of the human CD2 gene.

A CREB1-TGFβ2 self-sustaining loop in glioblastoma

A Smad transcriptional corepressor

A phorbol ester response element within the human T-cell receptor beta-chain enhancer ⬇️

A rapid strategy to detect the recombined allele in LSL-TβRICA transgenic mice.

A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis

Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor beta gene by protein kinase C, Ras plays multiple roles

An autoinhibitory effect of the homothorax domain of Meis2

Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene transcription

Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors

Cooperative binding of Ets-1 and core binding factor to DNA

Cooperative transcriptional activation by Klf4, Meis2, and Pbx1

Determinants of specificity in TGF-beta signal transduction.

Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy

Drosophila TGIF proteins are transcriptional activators

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning

Identification and functional analysis of the transcriptional enhancer of the human T cell receptor β gene ⬇️

Inhibition of CtBP1 activity by Akt-mediated phosphorylation

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway

Maternal Tgif is required for vascularization of the embryonic placenta

Multimerization of Hsp42p, a novel heat shock protein of Saccharomyces cerevisiae, is dependent on a conserved carboxyl-terminal sequence.

Multiple activities contribute to Pc2 E3 function

Multiple modes of repression by the Smad transcriptional corepressor TGIF

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 ⬇️

Pc2 and SUMOylation

Premature senescence and increased TGFβ signaling in the absence of Tgif1.

Prostate cancer induced by loss of Apc is restrained by TGFβ signaling

Rap1p and telomere length regulation in yeast.

Regulation of human T cell receptor beta gene expression by Ets-1.

SUMO and Chromatin Remodeling

Smad transcriptional corepressors in TGF beta family signaling.

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition.

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.

TGF-β drives DNA demethylation

TGFβ signaling limits lineage plasticity in prostate cancer.

TGIF inhibits retinoid signaling

TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth

TGIF2 interacts with histone deacetylase 1 and represses transcription

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse

Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l

Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation

Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells

Tgif1 represses apolipoprotein gene expression in liver

The Runx3 distal transcript encodes an additional transcriptional activation domain

The Smad transcriptional corepressor TGIF recruits mSin3

The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila

The Tgif2 gene contains a retained intron within the coding sequence

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF

The polycomb protein Pc2 is a SUMO E3

The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression

Transcriptional control by the TGF-beta/Smad signaling system

dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2.