List of works - Andreas C Joerger

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

scientific article published on 22 August 2016

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

scientific article published on 01 October 2019

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

scientific article

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

scientific article published on 21 April 2018

Catalytic action of fuculose 1-phosphate aldolase (class II) as derived from structure-directed mutagenesis

scientific article

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

scientific article

Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro

scientific article published on 22 June 2007

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

scientific article

Design of a molecular support for cryo-EM structure determination

scientific article

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains

scientific article published on 5 June 2006

Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level.

scientific article published on 14 April 2011

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

scientific article

Evaluating Drosophila p53 as a model system for studying cancer mutations

scientific article

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

scientific article published on 07 March 2022

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

scientific article published on 17 September 2015

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

scientific article published on December 2015

Extending the Code of Sequence Readout by Gene Regulatory Proteins: The Role of Hoogsteen Base Pairing in p53-DNA Recognition

scientific article published on 01 September 2018

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

scientific article

Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

scientific article

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

scientific article

Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs

scientific article published on 05 January 2021

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

scientific article

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

scientific article

Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity

scientific article (publication date: 13 May 2003)

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

scientific article published on 26 January 2019

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis

scientific article published on 20 November 2020

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases

scientific article

Principles and applications of halogen bonding in medicinal chemistry and chemical biology

scientific article published on 3 January 2013

Protein evolution via amino acid and codon elimination

scientific article

Small molecule induced reactivation of mutant p53 in cancer cells

scientific article

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

scientific article

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

scientific article published on December 2010

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

scholarly article

Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators

scientific article published in 2024

Structural biology of the tumor suppressor p53 and cancer-associated mutants

scientific article published on January 2007

Structural biology of the tumor suppressor p53.

scientific article published on January 2008

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

scientific article

Structure and Kinetic Stability of the p63 Tetramerization Domain

scientific article

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

scientific article published on 9 February 2005

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

scientific article

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

scientific article published on 21 February 2020

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

scientific article published on 4 May 2016

The structure of the FYR domain of transforming growth factor beta regulator 1

scientific article

The tumor suppressor p53: from structures to drug discovery

scientific article published on 10 February 2010

Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant

scientific article

Tracing the evolution of the p53 tetramerization domain

scientific article

List of works by Andreas C Joerger

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

Catalytic action of fuculose 1-phosphate aldolase (class II) as derived from structure-directed mutagenesis

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

Design of a molecular support for cryo-EM structure determination

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains

Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level.

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

Evaluating Drosophila p53 as a model system for studying cancer mutations

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

Extending the Code of Sequence Readout by Gene Regulatory Proteins: The Role of Hoogsteen Base Pairing in p53-DNA Recognition

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases

Principles and applications of halogen bonding in medicinal chemistry and chemical biology

Protein evolution via amino acid and codon elimination

Small molecule induced reactivation of mutant p53 in cancer cells

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators

Structural biology of the tumor suppressor p53 and cancer-associated mutants

Structural biology of the tumor suppressor p53.

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

Structure and Kinetic Stability of the p63 Tetramerization Domain

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

The structure of the FYR domain of transforming growth factor beta regulator 1

The tumor suppressor p53: from structures to drug discovery

Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant

Tracing the evolution of the p53 tetramerization domain