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List of works by Eric W-F Lam

11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes.

scientific article published on 12 August 2016

A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2

scientific article published on 26 February 2020

A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival

scientific article published on 9 March 2012

A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance

scientific article

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

scientific article published on December 2006

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?

scientific article

ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance

scientific article published on 25 April 2011

Activation of Aurora A kinase increases YAP stability via blockage of autophagy

scientific article published on 03 June 2019

Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation

scientific article published on 17 August 2016

An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase

scientific article published on November 2002

An open-label study of lapatinib in women with HER-2-negative early breast cancer: the lapatinib pre-surgical study (LPS study) ⬇️

scientific article published on December 11, 2012

Androgens target prohibitin to regulate proliferation of prostate cancer cells.

scientific article published on April 2004

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis

scientific article published on 20 February 2017

Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy

scientific article

BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells

scientific article published on 01 November 2001

BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells

scientific article published in April 2003

BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.

scientific article published on 25 April 2001

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.

scientific article

BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer

scientific article

BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer

scientific article published on 4 April 2016

Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb

scientific article

Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells

scientific article published on 09 December 2004

Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis

scientific article published on 23 February 2010

CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression

scientific article published on 6 March 2009

CD40: a pivotal receptor in the determination of life/death decisions in B lymphocytes.

scientific article published on January 1997

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

scientific article published on November 2002

Cell-cycle regulation of human B-myb transcription.

scientific article

Cellular Senescence: The Sought or the Unwanted?

scientific article published on 25 August 2018

Cellular senescence and aging: the role of B-MYB

scientific article

Characterization and cell cycle-regulated expression of mouse B-myb

scientific article published on September 1, 1992

Characterization of FOXO Acetylation

scientific article published on 01 January 2019

Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer

scholarly article by John Wahba et al published November 2018 in Cancer Immunology, Immunotherapy

Chronic Protein Kinase B (PKB/c-akt) Activation Leads to Apoptosis Induced by Oxidative Stress-Mediated Foxo3a Transcriptional Up-regulation

scientific article published on 01 November 2006

Commitment point during G0-->G1 that controls entry into the cell cycle

scientific article

Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

scientific article

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

scientific article

Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y).

scientific article

Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.

scientific article

Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence

scientific article published on 25 June 2018

Cyclin D2 controls B cell progenitor numbers

scientific article published on 11 November 2003

Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development

article

Cyclin D3 Compensates for Loss of Cyclin D2 in Mouse B-lymphocytes Activated via the Antigen Receptor and CD40

scientific article published in Journal of Biological Chemistry

DP and E2F proteins: coordinating transcription with cell cycle progression.

scientific article published on December 1994

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein

scientific article

Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism

scientific article published on 8 March 2017

Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer

scientific article

Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen.

scientific article

Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization

scientific article

Direct relation between BCR-ABL tyrosine kinase activity and cyclin D2 expression in lymphoblasts.

scientific article published in November 2001

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

scientific article published on March 2005

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

scientific article published in March 2008

Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways

scientific article published on 12 April 2017

EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer

scientific article published on 28 July 2019

ER stress and cancer: The FOXO forkhead transcription factor link

scientific article published on 29 May 2017

ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer

scientific article

Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A

scientific article

Erratum to: In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs

scientific article

Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells

scientific article published on April 2007

Estrogen receptor β upregulated by lncRNA-H19 to promote cancer stem-like properties in papillary thyroid carcinoma

scientific article published on 02 November 2018

Exogenous FABP4 increases breast cancer cell proliferation and activates the expression of fatty acid transport proteins.

scientific article

Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours

scientific article published on 23 June 2009

Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

scientific article published on October 2003

Expression profiling and significance of VEGF-A, VEGFR2, VEGFR3 and related proteins in endometrial carcinoma

scientific article published on 4 May 2014

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

scientific article

FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ

scientific article

FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.

scientific article published on 22 December 2014

FOXD3 controls pluripotency through modulating enhancer activity

scientific article

FOXK2 Transcription Factor and Its Emerging Roles in Cancer

scientific article published on 20 March 2019

FOXM1 confers acquired cisplatin resistance in breast cancer cells

scientific article

FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance

scientific article

FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance.

scientific article published on 18 May 2010

FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs

scientific article

FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression

scientific article published in Scientific Reports

FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance

scholarly article by Kitti Intuyod et al published 11 December 2018 in Cell Death and Disease

FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells.

scientific article

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

scientific article published on 21 October 2013

FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance.

scientific article published on 21 September 2015

FOXM1: A key oncofoetal transcription factor in health and disease

scientific article

FOXM1: From cancer initiation to progression and treatment.

scientific article published on 29 September 2011

FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance

scientific article

FOXO and FOXM1 in Cancer: The FOXO-FOXM1 Axis Shapes the Outcome of Cancer Chemotherapy

scientific article published on 01 August 2011

FOXO transcription factors and their role in disorders of the female reproductive tract.

scientific article published in August 2011

FOXO3a and Posttranslational Modifications Mediate Glucocorticoid Sensitivity in B-ALL.

scientific article published on 16 September 2015

FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer.

scientific article published on 29 September 2016

FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1.

scientific article published on 27 November 2006

FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells

scientific article published on October 2008

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

scientific article

Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells.

scientific article published in April 2003

Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer.

scientific article published on 07 September 2015

Forkhead box proteins: tuning forks for transcriptional harmony.

scientific article published on July 2013

Forkhead box transcription factors in cancer initiation, progression and chemotherapeutic drug response

scientific article published on 29 October 2014

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

scientific article

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer

scientific article

FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression.

scientific article published on 11 April 2008

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

scientific article

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

scientific article (publication date: 12 December 2003)

Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster.

scientific article

Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells.

scientific article

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer

scientific article published on 10 March 2009

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

scientific article published on 6 November 2017

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

scientific article published on 18 December 2017

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

scientific article published on 19 January 2017

H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression

scientific article published on 4 February 2002

Heparin prevents programmed cell death in human trophoblast

scientific article published on 23 March 2006

Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation

scientific article

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines

scientific article

Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells

scientific article

Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.

scientific article published on 7 September 2006

ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line

scientific article

IKKα restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation

scientific article published on 17 April 2014

Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network

scientific article published on 12 December 2007

Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

scientific article published on 24 August 2020

In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs

scientific article published in January 2016

In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.

scientific article

Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression

scientific article

Inflammation and sex steroid receptors: a motif for change

scientific article published in February 2006

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

scientific article published in Journal of Biological Chemistry

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance.

scientific article

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

scientific article published on 30 December 2010

Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1

scientific article (publication date: 6 September 2002)

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

scientific article published on 14 November 2019

Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor.

scientific article published on 15 November 2006

Ligation of the WC1 receptor induces gamma delta T cell growth arrest through fumonisin B1-sensitive increases in cellular ceramide.

scientific article

Loss of Endometrial Plasticity in Recurrent Pregnancy Loss.

scientific article published on 29 September 2015

Many forks in the path: cycling with FoxO.

scientific article published on April 2008

Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells.

scientific article

Mechanisms of endometrial progesterone resistance

scientific article

Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle.

scientific article

Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth.

scientific article published on 14 December 2006

Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line

scientific article published on 10 April 2017

Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer

scientific article published on 19 December 2017

Modulation of E2F Activity via Signaling through Surface IgM and CD40 Receptors in WEHI-231 B Lymphoma Cells

scientific article published in Journal of Biological Chemistry

Modulation of oxidative phosphorylation augments antineoplastic activity of mitotic aurora kinase inhibition

scientific article published on 30 September 2021

Multifaceted link between metabolism and cancer

scientific article published on 25 March 2017

Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.

scientific article published on 2 September 2005

NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling.

scientific article

NEDDylation negatively regulates ERRβ expression to promote breast cancer tumorigenesis and progression

scientific article published on 24 August 2020

Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

scientific article published on 19 January 2016

O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1

scientific article published on 18 June 2018

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

scientific article

Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells

scientific article published on 28 August 2020

Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance

scientific article

Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers

scientific article

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.

scientific article

Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

scientific article published on January 2006

Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes.

scientific article

Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer

scientific article published on 17 February 2020

Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin

scientific article

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

scientific article

Progesterone and FOXO1 signaling: harnessing cellular senescence for the treatment of ovarian cancer

scientific article published on 17 May 2013

Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium

scientific article published on 25 August 2005

Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis

scientific article published on 12 February 2007

Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection

scientific article published on 29 March 2005

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment

scientific article published on 15 August 2016

Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters ⬇️

scientific article published on June 20, 2012

Rapid dephosphorylation of p107 following UV irradiation.

scientific article published on January 1999

Rapid temporal control of Foxp3 protein degradation by sirtuin-1.

scientific article

Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia

scientific article published on 30 May 2018

Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues.

scientific article

Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells

scientific article published on 16 July 2019

Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone

scientific article

Resist or die: FOXO transcription factors determine the cellular response to chemotherapy.

scientific article published on 5 October 2008

Review: lapatinib in metastatic colorectal cancer-another strategy for disease control?

scientific article published on June 1, 2011

Role and Regulation of the Serum- and Glucocorticoid-Regulated Kinase 1 in Fertile and Infertile Human Endometrium

article

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance.

scientific article published on 27 May 2013

Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

scientific article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

scientific article

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

scientific article published on 6 April 2010

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.

scientific article published on 20 March 2013

STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment

scientific article published on 12 November 2015

SUMOylation inhibits FOXM1 activity and delays mitotic transition.

scientific article

SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells

scientific article published on 13 March 2018

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

scientific article published on 04 May 2020

Sense and sensitivity: FOXO and ROS in cancer development and treatment

scientific article published on 20 October 2010

Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals

scientific article

Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins

scientific article published in January 2016

Steroid receptor action

scientific article published on April 2004

Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt

scientific article

Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

scientific article

Targeting FOXM1

scientific article published on 01 March 2008

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

scientific article published in Nature Communications

The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.

scientific article

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

scientific article published on 24 November 2017

The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells

scientific article

The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.

scientific article published on 15 July 2013

The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer

scientific article

The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium

scientific article

The biological effects of C/EBPalpha in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain

scientific article

The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells

scientific article published on 8 January 2015

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

scientific article published on 09 January 2019

The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines

scientific article

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

scientific article

The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer

scientific article published on 07 March 2011

The emerging roles of forkhead box (Fox) proteins in cancer

scientific article

The expression of ER beta cx in human breast cancer and the relationship to endocrine therapy and survival

scientific article published on April 2004

The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours

scientific article published on 14 December 2009

The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma

scientific article

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

scientific article published on 21 July 2008

The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27(Kip1).

scientific article published on 7 February 2010

The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells.

scientific article published on May 2001

The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells

scientific article published on 22 June 2009

The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment.

scientific article

The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter.

scientific article published on May 1998

The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

scientific article

The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors

scientific article published on 21 August 2014

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

scientific article published on 30 April 2018

The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells

scientific article published on December 2007

The transcription factor encyclopedia

scientific article (publication date: 2012)

Therapeutic strategies targeting FOXO transcription factors

scientific article published on 10 November 2020

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.

scientific article

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

scientific article

Transcription factor E2F controls the reversible gamma delta T cell growth arrest mediated through WC1 ⬇️

scientific article published on August 15, 1998

Transcription regulation by murine B-myb is distinct from that by c-myb.

scientific article published on January 1993

Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells

scientific article published on 3 July 2007

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

scientific article published on 23 October 2020

Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.

scientific article

Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis.

scientific article published on 10 January 2017

Value of SERMs in postmenopausal women

scientific article published in May 2004

Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor.

scientific article

Vav-Dependent and Vav-Independent Phosphatidylinositol 3-Kinase Activation in Murine B Cells Determined by the Nature of the Stimulus

scientific article published on 01 September 2004

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin

scientific article published on 01 March 2020

iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe

scientific article published on 16 September 2011

p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo.

scientific article

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA.

scientific article published on 27 June 2016

p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis.

scientific article

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