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List of works by Renata Silva

"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.

scientific article

3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions.

scientific article published on 16 December 2015

Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes

scientific article

Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes

scientific article published on 24 December 2008

Boosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles

scientific article published on 12 July 2019

Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP.

scientific article published on 8 April 2017

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.

scientific article published on 10 March 2018

Cocaine-induced kidney toxicity: an in vitro study using primary cultured human proximal tubular epithelial cells

scientific article published on 8 October 2011

Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples

scientific article published on 23 February 2010

Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate

scientific article (publication date: 2013)

Disclosing the Antifungal Mechanisms of the Cyclam Salt H4[H2(4-CF3PhCH2)2Cyclam]Cl4 against Candida albicans and Candida krusei

scientific article published on 10 May 2024

Effect of colchicine on P-glycoprotein expression and activity in Caco2 cells

Evaluation of GSH adducts of adrenaline in biological samples

scientific article published in July 2007

First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells

scientific article

Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.

scientific article published on 31 October 2009

In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells ⬇️

scientific article published on September 21, 2010

Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat

scientific article published on 25 January 2014

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity

scientific article published on November 2006

Influence of aging and prostatic disease in the expression and activity of P-glycoprotein in human lymphocytes

Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin.

scientific article published on 16 May 2013

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.

scientific article

New Thermoresponsive Eyedrop Formulation Containing Ibuprofen Loaded-Nanostructured Lipid Carriers (NLC): Development, Characterization and Biocompatibility Studies.

scientific article published on 27 October 2015

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

scientific article published on 21 August 2020

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies

scientific article published on 15 February 2019

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH Adduct

scientific article published on 13 July 2007

P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies

scientific article published on 19 November 2019

P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging

scientific article published on 8 September 2011

P-glycoprotein induction as a cellular protection tool against xenobiotics toxicity

P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.

scientific article

PEGylated PLGA nanoparticles as a smart carrier to increase the cellular uptake of a coumarin-based monoamine oxidase B inhibitor

scientific article published on 09 November 2018

Piperazine designer drugs are cytotoxic to human neuroblastoma SH-SY5Y cells

scholarly article by Marcelo Arbo et al published September 2014 in Toxicology Letters

Piperazine designer drugs induce toxicity in cardiomyoblast h9c2 cells through mitochondrial impairment.

scientific article

Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.

scientific article published on 20 December 2015

Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes

scientific article

Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.

scientific article

Quantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometry

scientific article published on 04 May 2018

RBE4 cells are highly resistant to paraquat-induced cytotoxicity: studies on uptake and efflux mechanisms.

scientific article published on 18 September 2013

Several transport systems contribute to the intestinal uptake of Paraquat, modulating its cytotoxic effects.

scientific article

The Use of Feathers from Racing Pigeons for Doping Control Purposes

scientific article published on 01 May 2019

The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations

scientific article

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