List of works - Nico Mitro

"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer

scientific article published on 21 November 2020

Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy

scientific article

Age-related changes in bile acid synthesis and hepatic nuclear receptor expression

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle

scientific article published on 29 March 2016

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases.

scientific article published on 31 October 2016

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.

scientific article published on 19 January 2018

Bile acids and gene regulation: from nuclear receptors to chromatin.

scientific article published on May 2008

Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.

scientific article published on October 2007

Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38)

scientific article

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

scientific article published on 25 October 2019

Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis

scientific article published in March 2006

Diabetes alters myelin lipid profile in rat cerebral cortex: Protective effects of dihydroprogesterone.

scientific article

Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex.

scientific article published on 25 November 2017

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

scientific article published on 7 December 2011

Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.

scientific article

Dihydrotestosterone as a Protective Agent in Chronic Experimental Autoimmune Encephalomyelitis.

scientific article published on 26 February 2015

Dissection of the insulin-sensitizing effect of liver X receptor ligands

scientific article published on 23 August 2007

Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38.

scientific article published on 4 October 2017

ELOVL5 mutations cause spinocerebellar ataxia 38

scientific article

Elovl5 is required for proper action potential conduction along peripheral myelinated fibers

scientific article published on 17 June 2021

Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function.

scientific article

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

scientific article published on 04 February 2019

Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile

scientific article published on 28 November 2017

FABP1 in wonderland

scientific article

Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection

scientific article published on 22 December 2017

Fluorescence Resonance Energy Transfer Techniques to Study Ligand-Mediated Interactions of PPARs with Coregulators ⬇️

scientific article published on January 1, 2013

Gender-related metabolomics and lipidomics: From experimental animal models to clinical evidence.

scientific article published on 6 November 2017

Gene set enrichment in eQTL data identifies novel annotations and pathway regulators

scientific article

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

scientific article published on 21 July 2017

High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants

scientific article published on 01 April 2005

In vitro and in vivo evaluation of silk fibroin functionalized with GABA and allopregnanolone for Schwann cell and neuron survival

scientific article published on 21 November 2017

Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue

scientific article published on 15 October 2012

Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.

scientific article

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

scientific article

Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice.

scientific article published on 17 January 2018

Investigating metabolism by mass spectrometry: From steady state to dynamic view

scientific article published on 29 September 2020

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.

scientific article published on 22 January 2014

LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.

scientific article published on February 2004

LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals

scientific article published on 03 March 2012

Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy

scientific article published on 26 March 2015

Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions.

scientific article published on 16 August 2013

Linking epigenetics to lipid metabolism: focus on histone deacetylases.

scientific article

Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology.

scientific article

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

scientific article

Liver X receptors, nervous system, and lipid metabolism.

scientific article published on 18 April 2013

Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells

scientific article published in 2022

Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue

scientific article published on 09 July 2020

Metabolic control of DNA methylation in naive pluripotent cells

scientific article published on 01 February 2021

Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation

Mitochondria, lysosomes, and dysfunction: their meaning in neurodegeneration

scientific article published on 02 August 2018

Mitochondrial dysfunction increases fatty acid β-oxidation and translates into impaired neuroblast maturation

scientific article published on 31 August 2019

Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice

scientific article

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

scientific article published in Nature Communications

N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.

scientific article published on August 2007

Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy

scientific article published on 04 March 2014

Neuroactive steroids and diabetic complications in the nervous system.

scientific article

Neuroactive steroids and the peripheral nervous system: An update.

scientific article published on 28 March 2015

Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model

scientific article published on 19 December 2020

Non-insulin anti-diabetic drugs: An update on pharmacological interactions.

scientific article published on 9 November 2016

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

scientific article published on 30 January 2017

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells.

scientific article published on 27 April 2015

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

scientific article published in 2021

Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells

scientific article

Role of neuroactive steroids in the peripheral nervous system

scientific article

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.

scientific article published on 23 November 2016

Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.

scientific article

Sterol regulatory element binding protein-1C knockout mice show altered neuroactive steroid levels in sciatic nerve.

scientific article published on 3 May 2017

Sterol-protein interactions in cholesterol and bile acid synthesis.

scientific article published on January 2010

Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis

scientific article published on June 2010

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors

scientific article

Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage.

scientific article published on 7 May 2018

Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity

scientific article published on August 2005

Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity

scientific article

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

scientific article published on 30 March 2007

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells.

scientific article published on 5 June 2017

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

scientific article published on 12 June 2015

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

scientific article published on 11 June 2001

The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells

scientific article published on 08 April 2020

The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.

scientific article published on 07 September 2007

The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism

scientific article published on 03 February 2014

The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

scientific article published on May 2007

Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure

scientific article published in 2021

Treatment with LXR agonists after focal cerebral ischemia prevents brain damage

scientific article published on 19 September 2008

When food meets man: the contribution of epigenetics to health.

scientific article published on 25 May 2010

Zc3h10 is a novel mitochondrial regulator.

scientific article published on 5 March 2018

microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease.

scientific article published on 7 October 2017

List of works by Nico Mitro

"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer

Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy

Age-related changes in bile acid synthesis and hepatic nuclear receptor expression

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases.

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.

Bile acids and gene regulation: from nuclear receptors to chromatin.

Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.

Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38)

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis

Diabetes alters myelin lipid profile in rat cerebral cortex: Protective effects of dihydroprogesterone.

Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex.

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.

Dihydrotestosterone as a Protective Agent in Chronic Experimental Autoimmune Encephalomyelitis.

Dissection of the insulin-sensitizing effect of liver X receptor ligands

Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38.

ELOVL5 mutations cause spinocerebellar ataxia 38

Elovl5 is required for proper action potential conduction along peripheral myelinated fibers

Energizing Genetics and Epi-genetics: Role in the Regulation of Mitochondrial Function.

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile

FABP1 in wonderland

Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection

Fluorescence Resonance Energy Transfer Techniques to Study Ligand-Mediated Interactions of PPARs with Coregulators ⬇️

Gender-related metabolomics and lipidomics: From experimental animal models to clinical evidence.

Gene set enrichment in eQTL data identifies novel annotations and pathway regulators

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants

In vitro and in vivo evaluation of silk fibroin functionalized with GABA and allopregnanolone for Schwann cell and neuron survival

Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue

Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice.

Investigating metabolism by mass spectrometry: From steady state to dynamic view

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.

LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.

LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals

Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy

Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions.

Linking epigenetics to lipid metabolism: focus on histone deacetylases.

Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology.

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

Liver X receptors, nervous system, and lipid metabolism.

Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells

Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue

Metabolic control of DNA methylation in naive pluripotent cells

Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation

Mitochondria, lysosomes, and dysfunction: their meaning in neurodegeneration

Mitochondrial dysfunction increases fatty acid β-oxidation and translates into impaired neuroblast maturation

Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.

Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy

Neuroactive steroids and diabetic complications in the nervous system.

Neuroactive steroids and the peripheral nervous system: An update.

Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model

Non-insulin anti-diabetic drugs: An update on pharmacological interactions.

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells.

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells

Role of neuroactive steroids in the peripheral nervous system

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.

Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.

Sterol regulatory element binding protein-1C knockout mice show altered neuroactive steroid levels in sciatic nerve.

Sterol-protein interactions in cholesterol and bile acid synthesis.

Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors

Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage.

Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity

Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells.

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells

The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.