List of works - Maurizio Crestani

"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer

scientific article published on 21 November 2020

Age-related changes in bile acid synthesis and hepatic nuclear receptor expression

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle

scientific article published on 29 March 2016

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases.

scientific article published on 31 October 2016

Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.

scientific article published on October 2007

Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice.

scientific article published on 03 June 2015

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design

scientific article

Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis

scientific article published in March 2006

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.

scientific article

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

scientific article published on 7 December 2011

Dietary Mannan Oligosaccharides Modulate Gut Inflammatory Response and Improve Duodenal Villi Height in Post-Weaning Piglets Improving Feed Efficiency

scientific article published on 28 July 2020

Does microRNA Perturbation Control the Mechanisms Linking Obesity and Diabetes? Implications for Cardiovascular Risk

scientific article published on 25 December 2020

Effect of natural and structurally modified bile acids on cholesterol metabolizing enzymes in rat liver microsomes

scientific article published on 01 October 1989

Effect of tauroursodeoxycholate feeding, with or without taurine supplementation on hepatic bile acids and cholesterol metabolism in the hamster

scientific article published on 01 May 1987

Effects of a blend of essential oils and an enzyme combination on nutrient digestibility, ileum histology and expression of inflammatory mediators in weaned piglets.

scientific article

Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells

scientific article published on 01 January 1994

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.

scientific article published on 7 August 2009

Fluorescence Resonance Energy Transfer Techniques to Study Ligand-Mediated Interactions of PPARs with Coregulators ⬇️

scientific article published on January 1, 2013

Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).

scientific article published on November 1993

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

scientific article published on 21 July 2017

High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants

scientific article published on 01 April 2005

Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7alpha-hydroxylase gene promoter.

scientific article published on April 2000

Inflammatory serum proteome pattern in mice fed a high-fat diet.

scientific article published on 6 December 2012

Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue

scientific article published on 15 October 2012

Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.

scientific article

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

scientific article

Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry

scientific article published on 17 October 2019

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.

scientific article published on 22 January 2014

LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.

scientific article published on February 2004

Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy

scientific article published on 26 March 2015

Linking epigenetics to lipid metabolism: focus on histone deacetylases.

scientific article

Linking transcription to physiology in lipidomics

scientific article published on 06 November 2014

Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology.

scientific article

Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation

Mitochondrial dysfunction increases fatty acid β-oxidation and translates into impaired neuroblast maturation

scientific article published on 31 August 2019

Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.

scientific article published on 24 February 2013

Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy

scientific article published on 04 March 2014

Of mice and humans through the looking glass: "reflections" on epigenetics of lipid metabolism.

scientific article published on 21 January 2017

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells.

scientific article published on 27 April 2015

Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A)

scientific article published on 01 April 1997

Plasma lipoproteins and cholesterol metabolism in spontaneously hyperlipemic rats

scientific article published on 01 April 1989

Regulation of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7A): prevalence of negative over positive transcriptional control.

scientific article published on September 1996

Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.

scientific article

Sterol-protein interactions in cholesterol and bile acid synthesis.

scientific article published on January 2010

Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis

scientific article published on June 2010

Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans

scientific article published in August 2001

Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.

scientific article published on May 2007

Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity

scientific article published on August 2005

Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity

scientific article

The effect of etofibrate on cholesterol and bile acid metabolism in the hamster

scientific article published on 01 September 1989

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

scientific article published on 12 June 2015

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

scientific article published on 11 June 2001

The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.

scientific article published on 07 September 2007

The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism

scientific article published on 03 February 2014

When food meets man: the contribution of epigenetics to health.

scientific article published on 25 May 2010

[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).

scientific article published on April 2006

List of works by Maurizio Crestani

"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer

Age-related changes in bile acid synthesis and hepatic nuclear receptor expression

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases.

Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.

Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice.

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design

Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

Dietary Mannan Oligosaccharides Modulate Gut Inflammatory Response and Improve Duodenal Villi Height in Post-Weaning Piglets Improving Feed Efficiency

Does microRNA Perturbation Control the Mechanisms Linking Obesity and Diabetes? Implications for Cardiovascular Risk

Effect of natural and structurally modified bile acids on cholesterol metabolizing enzymes in rat liver microsomes

Effect of tauroursodeoxycholate feeding, with or without taurine supplementation on hepatic bile acids and cholesterol metabolism in the hamster

Effects of a blend of essential oils and an enzyme combination on nutrient digestibility, ileum histology and expression of inflammatory mediators in weaned piglets.

Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.

Fluorescence Resonance Energy Transfer Techniques to Study Ligand-Mediated Interactions of PPARs with Coregulators ⬇️

Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants

Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7alpha-hydroxylase gene promoter.

Inflammatory serum proteome pattern in mice fed a high-fat diet.

Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue

Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry

LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.

LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport.

Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy

Linking epigenetics to lipid metabolism: focus on histone deacetylases.

Linking transcription to physiology in lipidomics

Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology.

Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation

Mitochondrial dysfunction increases fatty acid β-oxidation and translates into impaired neuroblast maturation

Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.

Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy

Of mice and humans through the looking glass: "reflections" on epigenetics of lipid metabolism.

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells.

Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A)

Plasma lipoproteins and cholesterol metabolism in spontaneously hyperlipemic rats

Regulation of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7A): prevalence of negative over positive transcriptional control.

Site-directed mutagenesis to study the role of specific amino acids in the ligand binding domain of PPARs.

Sterol-protein interactions in cholesterol and bile acid synthesis.

Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis

Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans

Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.

Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity

Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity

The effect of etofibrate on cholesterol and bile acid metabolism in the hamster

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.

The sirtuin class of histone deacetylases: regulation and roles in lipid metabolism

When food meets man: the contribution of epigenetics to health.

[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).