List of works - Zinnia P Parra-Guillen

A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease

scientific article published on 10 December 2019

Assessment of Clinical Response to <scp>V937</scp> Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling

scientific article published in 2023

Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model

scientific article published on 21 December 2018

Disease pharmacokinetic-pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA-based therapies

scientific article published on 04 March 2020

Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients

scientific article published on 24 May 2017

Gene therapy: a pharmacokinetic/pharmacodynamic modelling overview.

scientific article published on 13 April 2010

Immune network for viral hepatitis B: Topological representation

scientific article published on 10 June 2019

Kinetic and Dynamic Computational Model-Based Characterization of New Proteins in Mice: Application to Interferon Alpha Linked to Apolipoprotein A-I ⬇️

scientific article published on July 27, 2012

Making use of modeling and simulations: Towards individualized tamoxifen therapy in breast cancer

scientific article published in August 2017

Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies

scientific article published on 19 April 2013

Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration

scientific article published on 23 July 2021

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria

scientific article published on 16 February 2022

Model Description Language (MDL): A Standard for Modeling and Simulation

scientific article published on 23 June 2017

Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody

scientific article published on 19 November 2019

Modeling tumor response after combined administration of different immune-stimulatory agents.

scientific article published on 11 July 2013

Pharmacokinetic/Pharmacodynamic Evaluation of Hydrocortisone Therapy in Pediatric Patients with Congenital Adrenal Hyperplasia

scientific article published on 01 March 2020

Pharmacokinetics and pharmacokinetic-pharmacodynamic relationships of monoclonal antibodies in children

scientific article

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.

scientific article published on 15 June 2015

Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer incorporating non-linear red blood cell uptake.

scientific article published on 30 October 2014

Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults.

scientific article

Review on modeling anti-antibody responses to monoclonal antibodies.

scientific article published on 16 July 2014

Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.

scientific article published on 26 April 2017

Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia.

scientific article published on 9 June 2017

Systematic modelling and design evaluation of unperturbed tumour dynamics in xenografts

scientific article published on 24 April 2018

Target-mediated disposition model describing the dynamics of IL12 and IFNγ after administration of a mifepristone-inducible adenoviral vector for IL-12 expression in mice.

scientific article published on 8 November 2012

The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing

scientific article published on 09 April 2019

The long neglected player: modeling tumor uptake to guide optimal dosing.

scientific article published on 26 March 2018

Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach

scientific article published on 22 April 2016

List of works by Zinnia P Parra-Guillen