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List of works by K.F. Rabe

A guide to guidelines for professional societies and other developers of recommendations: introduction to integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report

scientific article published on December 2012

A phase III study of triple therapy with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler 320/18/9.6 μg and 160/18/9.6 μg using co-suspension delivery technology in moderate-to-very severe COPD: The ETHOS study protocol

scientific article published on 22 August 2019

A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD.

scientific article published in October 2004

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

scientific article published on 08 January 2009

A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstr

scientific article published on 06 January 2017

A vision statement on guideline development for respiratory disease: the example of COPD.

scientific article published on 3 October 2008

Advanced Non-Small-Cell Lung Cancer

scientific article published in November 2017

Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA: Position paper of the German ARIA GroupA in cooperation with the Austrian ARIA GroupB, the Swiss ARIA GroupC, German Society for Applied A

scientific article published on 28 May 2020

Allergen-Immuntherapie in der aktuellen Covid-19-Pandemiea, b, c

scientific article published on 08 May 2020

An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease

scientific article published on April 2015

An Official American Thoracic Society/European Respiratory Society Statement: The Role of the Pulmonologist in the Diagnosis and Management of Lung Cancer ⬇️

scientific article published on August 15, 2013

An official American Thoracic Society and European Respiratory Society policy statement: disparities in respiratory health

scientific article published in October 2013

An official American Thoracic Society/European Respiratory Society policy statement: disparities in respiratory health

scientific article published in October 2013

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD.

scientific article published on April 2015

Anti-inflammatory effects of budesonide in human lung fibroblast are independent of histone deacetylase 2.

scientific article published on 20 August 2013

Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial

scientific article published on 14 September 2018

Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease

scientific article

Assessing small airway impairment in mild-to-moderate smoking asthmatic patients

scientific article published on 11 February 2016

Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma

scientific article published on 01 May 2002

Association of lung function measurements and visceral fat in men with metabolic syndrome.

scientific article

Asthma in the elderly: what we know and what we have yet to know

scientific article

Asthma transition from childhood into adulthood

scientific article published on 22 September 2016

Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.

scientific article

Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial

scientific article

Benefits of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI) in improving lung function and reducing exacerbations in patients with moderate-to-very severe COPD: a pooled analysis of the PINNACLE studies

scientific article published on 25 May 2020

Biomarkers Associated with Lung Function Decline and Dupilumab Response in Patients with Asthma

scholarly article

Breath volatile organic compounds and inflammatory markers in adult asthma patients - negative results from the ALLIANCE cohort

scientific article published on 02 October 2020

Brief Report: A Blood-Based MicroRNA Complementary Diagnostic Predicts Immunotherapy Efficacy in Advanced-Stage NSCLC With High Programmed Death-Ligand 1 Expression

scientific article published in 2022

Bronchopulmonary lymph nodes and large airway cell trafficking in patients with fatal asthma

scientific article published on 26 September 2014

Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial

scientific article published on February 2006

Burden of non-tuberculous mycobacterial pulmonary disease in Germany

scientific article published on 26 April 2017

CD8+ T cells characterize early smoking-related airway pathology in patients with asthma ⬇️

scientific article published on April 30, 2013

COPD EXACERBATION RATE BY BASELINE COPD ASSESSMENT TEST SCORE IN THE DYNAGITO STUDY ⬇️

scholarly article

COPD: more than respiratory – Authors' reply

scientific article published in The Lancet

Cardiovascular Safety in Patients Receiving Roflumilast for the Treatment of COPD ⬇️

scientific article published on September 1, 2013

Cardiovascular disease and COPD: dangerous liaisons?

scientific article published on 01 September 2018

Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial.

scientific article published on 29 October 2013

Chronic obstructive pulmonary disease

scientific article published on 11 May 2017

Chronic obstructive pulmonary disease and exacerbations: patient insights from the global Hidden Depths of COPD survey

scientific article

Chronic obstructive pulmonary disease phenotypes: the future of COPD.

scientific article published on 3 June 2010

Chronic sinusitis in severe asthma is related to sputum eosinophilia

scientific article published on 01 April 2002

Clinical Correlates of Reduced Physical Activity in Idiopathic Pulmonary Fibrosis.

scientific article published in June 2016

Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists

scientific article published on 01 June 2018

Comorbidities of patients in tiotropium clinical trials: comparison with observational studies of patients with chronic obstructive pulmonary disease

scientific article

Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients

scientific article published on 24 August 2009

Composite endpoints in COPD: clinically important deterioration in the UPLIFT trial

scientific article published on 09 July 2020

Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study

scientific article published on 01 September 2009

Controversies in treatment of chronic obstructive pulmonary disease ⬇️

scientific article published on September 10, 2011

Correction to: The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study

scientific article published on 07 November 2018

Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time

scientific article published on 17 November 2020

Determinants of Response to Roflumilast in Severe COPD: Pooled Analysis of Two Randomized Trials

scientific article published on 01 November 2018

Disease Progression and Changes in Physical Activity in Patients with Chronic Obstructive Pulmonary Disease

scientific article published on August 2015

Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? the REACT study protocol ⬇️

scientific article published on June 20, 2012

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

scientific article

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

article

Dupilumab Efficacy in Uncontrolled, Moderate-to-Severe Asthma With Self-reported Chronic Rhinosinusitis.

scientific article

Dupilumab Is Effective in Patients With Moderate-to-Severe Uncontrolled GINA-Defined Type 2 Asthma Irrespective of an Allergic Asthma Phenotype

scientific article published in 2022

Dupilumab improves lung function in patients with uncontrolled, moderate-to-severe asthma

scientific article published on 27 January 2020

Economic burden of bronchiectasis in Germany

scientific article published on 28 February 2019

Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations: a prespecified substudy of the POET-COPD trial

scientific article

Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting β2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial

scientific article published in September 2016

Effect of roflumilast in patients with severe COPD and a history of hospitalisation

scientific article

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.

scientific article

Effect of tiotropium vs. salmeterol on exacerbations: GOLD II and maintenance therapy naïve patients

scientific article published on 26 October 2012

Effects of airway obstruction and hyperinflation on electrocardiographic axes in COPD

scientific article published on 27 March 2019

Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione

scientific article

Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting β2-agonist fixed-dose combination: RE(2)SPOND rationale and study design

scientific article published on 17 August 2016

Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma

scientific article published on 23 May 2017

Efficacy and Safety of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Japanese Patients with COPD: A Subgroup Analysis of the KRONOS Study

scientific article published on 23 December 2019

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

scientific article published on 21 May 2018

Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD.

scientific article published in December 2016

Efficacy of Roflumilast in the COPD Frequent Exacerbator Phenotype ⬇️

scientific article published on May 1, 2013

Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge.

scientific article published in April 2005

Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13

scientific article published on 05 June 2006

Erratum to: A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe c

scientific article published on 21 August 2017

Erratum: asthma in the elderly: what we know and what we have yet to know.

scientific article published on 18 June 2014

Exacerbations of COPD

scientific article

Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0.

scientific article published on 19 October 2020

Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF) - a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial

scientific article published on 6 September 2017

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study

scientific article published on 12 March 2019

FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study

scientific article published on 3 February 2017

Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues

scientific article published on 16 October 2018

From COPD to chronic systemic inflammatory syndrome?

scientific article published in The Lancet

Global Initiative for Chronic Obstructive Lung Disease (GOLD) 20th Anniversary: a brief history of time

scientific article

Global Initiative on Obstructive Lung Disease Revised. What Constitutes a Guideline? ⬇️

scientific article published on May 15, 2013

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

scientific article

Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Lung Function versus Monotherapies in GOLD Category A Patients with COPD: Pooled Data from the Phase III PINNACLE Studies

scientific article published on 09 January 2020

Guidelines for diagnosis and therapy of patients with asthma 2005. The most important aspects for adults

scientific article published in January 2006

HOPE-preservation of paraffin-embedded sputum samples--a new way of bioprofiling in COPD.

scientific article

High-sensitivity troponin I and all-cause mortality in patients with stable COPD: an analysis of the COSYCONET study

scientific article published on 27 February 2020

How to integrate multiple comorbidities in guideline development: article 10 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report

scientific article published on December 2012

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis

scientific article published on 24 July 2018

Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors

scientific article published on 24 March 2006

Human neutrophil defensins induce lung epithelial cell proliferation in vitro.

scientific article published on July 2002

IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides ⬇️

scientific article published on May 2, 2011

Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease

article

Illness perceptions and quality of life in patients with chronic obstructive pulmonary disease

scientific article published in September 2007

Immune cell profile in infants’ lung tissue

scientific article published on 25 June 2013

Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast

scientific article

Influence of body mass on predicted values of static hyperinflation in COPD

Inhaled Long-Acting β-Agonists Versus Anticholinergics in Older Patients With Chronic Obstructive Pulmonary Disease

scientific article published on October 18, 2011

Inhaled corticosteroids in COPD: friend or foe?

scientific article published on 13 December 2018

Internet-based self-management plus education compared with usual care in asthma: a randomized trial

scientific article published in July 2009

Liberty Asthma QUEST: Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate Dupilumab Efficacy/Safety in Patients with Uncontrolled, Moderate-to-Severe Asthma.

scientific article

Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema

scientific article published on 11 September 2017

Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy

scientific article published on 12 November 2019

Long-Term Safety and Efficacy of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Japanese Patients with COPD

scientific article published on 23 December 2019

Longitudinal Impact of Sputum Inflammatory Phenotypes on Small Airway Dysfunction and Disease Outcomes in Asthma

scientific article published in 2022

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

scientific article published on 26 November 2020

Lung Function Abnormalities in Smokers with Ischemic Heart Disease

scientific article published on 21 July 2016

Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

scientific article published on 15 March 2017

Management of non-small-cell lung cancer: recent developments ⬇️

scientific article published on August 24, 2013

Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease

scientific article

Microbiological outcome of interventions against pulmonary MAC disease: A systematic review

scientific article published in February 2018

Multi-analyte profiling of inflammatory mediators in COPD sputum--the effects of processing

scientific article published on 15 November 2014

Nebulised budesonide using a novel device in patients with oral steroid-dependent asthma

scientific article published on 10 December 2014

Neutrophil Extracellular Trap Formation is regulated by CXCR2 in COPD neutrophils

scientific article published on 15 February 2018

Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients

scientific article published on 22 August 2015

New metrics for translational research

scientific article published in August 2014

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

scientific article

Peripheral eosinophil count as a biomarker for the management of COPD: not there yet.

scientific article published on 22 November 2017

Phosphodiesterase-4 inhibitor therapy for lung diseases

scientific article published on August 2013

Physical Activity and Fatigue in Patients with Sarcoidosis.

scientific article

Physical activity, airway resistance and small airway dysfunction in severe asthma

scientific article

Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function

scientific article published on 22 March 2017

Point: were industry-sponsored roflumilast trials appropriate? Yes

scientific article published on 01 May 2014

Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer

scientific article published in August 2017

Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study

scientific article published in 2022

Predictors of poor asthma control in European adults

scientific article

Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

scientific article published on 9 September 2017

Prof. Andrzej Szczeklik, 1938–2012: aspirin-induced asthma and much more: Figure 1–

scientific article published on 31 May 2012

Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis.

scientific article

Pulmonary rehabilitation for patients with COPD during and after an exacerbation-related hospitalisation: back to the future?

scientific article published on 11 January 2018

Pulmonologists and lung cancer: pivotal role in multidisciplinary approach

scientific article published in November 2013

RNA-seq based profiling of extracellular vesicles in plasma reveals a potential role of miR-122-5p in asthma

scientific article published on 05 July 2020

Rating sputum cell quality in clinical trials for asthma and COPD treatment

scientific article published on 08 January 2019

Rebuttal from Drs Suissa and Rabe

scientific article published on 01 May 2014

Reduced All-Cause Mortality in the ETHOS Trial of Budesonide/Glycopyrrolate/Formoterol for COPD: A Randomized, Double-Blind, Multi-Center Parallel-Group Study

scientific article published on 30 November 2020

Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease

scientific article published on 7 September 2017

Reduced physical activity in lymphangioleiomyomatosis compared with COPD and healthy controls: disease-specific impact and clinical correlates

scientific article published on 11 March 2016

Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD

scientific article

Reporting and publishing guidelines: article 12 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report

scientific article published on December 2012

Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells

scientific article published on 31 January 2014

Respiratory diseases in the world: one voice "united for lung health"

article

Response

Rhinovirus infections change DNA methylation and mRNA expression in children with asthma

scientific article published in PLoS ONE

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

scientific article published in August 2009

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

scientific article published in August 2009

Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial

scientific article published in August 2005

Roflumilast: a review of its use in the treatment of COPD

scientific article

Role of defensins in inflammatory lung disease

scientific article

Role of dual bronchodilators in COPD: A review of the current evidence for indacaterol/glycopyrronium

scientific article published on 04 April 2017

Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: A randomized controlled trial

scientific article published on 24 March 2019

Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies

scientific article published on 9 December 2015

Seasonal distribution of COPD exacerbations in the Prevention of Exacerbations with Tiotropium in COPD trial.

scientific article

Selective phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease

scientific article

Severe asthma in adults: what are the important questions?

scientific article

Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study

scientific article published on 21 October 2020

Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population

scientific article

Systems medicine and integrated care to combat chronic noncommunicable diseases

scientific article

TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells

scientific article published on 01 October 2004

The European Respiratory Society plans its future: the 2013-2018 strategic plan

scientific article published in April 2014

The EvA study: aims and strategy.

scientific article

The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC

scientific article published on 01 January 2019

The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study

scientific article published on 20 August 2018

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

scientific article published on December 2003

The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells

scientific article published on 01 June 2006

The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard thera

scientific article published on 20 July 2012

The effect of dithiothreitol on the transcriptome of induced sputum cells.

scientific article published on 9 April 2013

The efficacy and safety of cilomilast in COPD.

scientific article

The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung

scientific article

The use of auto-antibody testing in the evaluation of interstitial lung disease (ILD)--A practical approach for the pulmonologist

scientific article published on February 2016

The year of the lung

scientific article published on 01 September 2010

Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial

scientific article published on 28 March 2018

Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD ⬇️

scientific article published on March 24, 2011

Tiotropium/Olodaterol Delays Clinically Important Deterioration Compared with Tiotropium Monotherapy in Patients with Early COPD: a Post Hoc Analysis of the TONADO® Trials

scientific article published on 11 November 2020

Towards a total ban on links with the tobacco industry: new rules for the ERS ⬇️

scientific article published on October 1, 2012

Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD

scientific article published on 24 June 2020

Triple Inhaled Therapy in COPD. Reply

scientific article published on 01 October 2020

Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary disease (KRONOS): a double-blind, parallel-group, multicentre, phase 3 randomised control

scientific article published on 16 September 2018

Uncovering and tackling Europe's hidden respiratory illness ⬇️

scientific article published on August 18, 2012

Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

article

Unmet needs for the assessment of small airways dysfunction in asthma: introduction to the ATLANTIS study

scientific article published in June 2015

Update in chronic obstructive pulmonary disease 2005.

scientific article

Update in chronic obstructive pulmonary disease 2006.

scientific article published on June 2007

Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD.

scientific article published on 6 March 2018

Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)A, Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)B, Gesellsch

scientific article published on 07 September 2020

Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys

article published in 2004

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