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List of works by Matthias Bauer

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

scientific article published on 22 August 2016

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

scientific article published on 01 October 2019

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway ⬇️

scientific article published on 6 March 2018

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

scientific article published on 21 April 2018

Applying DEKOIS 2.0 in structure-based virtual screening to probe the impact of preparation procedures and score normalization

scientific article (publication date: 2015)

DEKOIS: Demanding Evaluation Kits for Objective in Silico Screening — A Versatile Tool for Benchmarking Docking Programs and Scoring Functions ⬇️

scientific article published on August 18, 2011

Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes

scientific article published on 13 March 2019

Evaluation and Optimization of Virtual Screening Workflows with DEKOIS 2.0 – A Public Library of Challenging Docking Benchmark Sets ⬇️

scientific article published on June 12, 2013

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

scientific article published on 17 September 2015

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

scientific article published on December 2015

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

scientific article

Hitting a moving target: targeting transient protein states.

scientific article published in December 2013

Inferring multi-target QSAR models with taxonomy-based multi-task learning.

scientific article published on 11 July 2013

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

scientific article

Machine learning estimates of natural product conformational energies

scientific article published on 16 January 2014

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007.

scientific article

Probing the impact of protein and ligand preparation procedures on chemotype enrichment in structure-based virtual screening using DEKOIS 2.0 benchmark sets.

scientific article published on 11 March 2014

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

scientific article published on 10 August 2019

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

scientific article published on 28 December 2010

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

scientific article published on 21 February 2020

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.

scientific article

Use of DEKOIS 2.0 to gain insights for virtual screening.

scientific article

pROC-Chemotype Plots Enhance the Interpretability of Benchmarking Results in Structure-Based Virtual Screening.

scientific article

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