List of works - Paul Donaldson

A computer model of lens structure and function predicts experimental changes to steady state properties and circulating currents

scientific article published on 30 August 2013

A link between maternal malnutrition and depletion of glutathione in the developing lens: a possible explanation for idiopathic childhood cataract?

scientific article published on 25 June 2013

Active Maintenance of the Gradient of Refractive Index Is Required to Sustain the Optical Properties of the Lens.

scientific article

Alterations of Glutamate, Glutamine, and Related Amino Acids in the Anterior Eye Secondary to Ischaemia and Reperfusion ⬇️

scientific article published on May 15, 2012

An exploration into diffusion tensor imaging in the bovine ocular lens.

scientific article published on March 2013

Antioxidant delivery pathways in the anterior eye.

scientific article published on 26 September 2013

Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements.

scientific article

Cellular Localization of Glutamate and Glutamine Metabolism and Transport Pathways in the Rat Ciliary Epithelium

scientific article published on 18 May 2011

Characterization of glutathione uptake, synthesis, and efflux pathways in the epithelium and endothelium of the rat cornea.

scientific article published in November 2012

Characterization of the Effects of Hyperbaric Oxygen on the Biochemical and Optical Properties of the Bovine Lens.

scientific article

Characterization of the cystine/glutamate transporter in the outer plexiform layer of the vertebrate retina

scientific article published in October 2008

Cl- influx into rat cortical lens fiber cells is mediated by a Cl- conductance that is not ClC-2 or -3.

scientific article published in December 2004

Confocal microscopy reveals zones of membrane remodeling in the outer cortex of the human lens

scientific article

Development of a 3D finite element model of lens microcirculation

scientific article (publication date: 19 September 2012)

Differential membrane redistribution of P2X receptor isoforms in response to osmotic and hyperglycemic stress in the rat lens

scientific article published on 14 March 2009

Differentiation-dependent changes in the membrane properties of fiber cells isolated from the rat lens

scientific article published on 26 March 2008

Differentiation-dependent modification and subcellular distribution of aquaporin-0 suggests multiple functional roles in the rat lens.

scientific article published on 31 October 2008

Dynamic regulation of GSH synthesis and uptake pathways in the rat lens epithelium

scientific article published on 23 November 2009

Effects of ADH on the apical and basolateral membranes of toad urinary bladder epithelial cells.

scientific article

Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract

scientific journal article

Fatty Acid uptake and incorporation into phospholipids in the rat lens

scientific article

Fluid in Equals Fluid Out—Evidence for Circulating Fluid Fluxes in the Lens ⬇️

scientific article published on November 19, 2012

Focus on molecules: the cystine/glutamate exchanger (System x(c)(-)).

scientific article published on 19 May 2010

Functional imaging: new views on lens structure and function.

scientific article published in December 2004

Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens.

scientific article published on January 2004

Glutamate metabolic pathways and retinal function

scientific article published on 22 August 2009

Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens

Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage

scientific article published on 10 October 2012

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses

scientific journal article

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues

scientific article published on 18 June 2020

Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.

scientific article published in November 2003

Intracellular ionic activities in the EDL muscle of the mouse

scientific article published on 01 February 1984

Localised fibre cell swelling characteristic of diabetic cataract can be induced in normal rat lens using the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid

scientific article published on 01 January 1999

MALDI imaging mass spectrometry of β- and γ-crystallins in the ocular lens

scientific article published on 05 December 2019

Magnetic resonance and confocal imaging of solute penetration into the lens reveals a zone of restricted extracellular space diffusion

scientific article published on 11 April 2012

Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix-assisted laser desorption/ionisation imaging mass spectrometry method

scientific article published on 14 October 2020

Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core

scientific article

Microelectrode studies of toad urinary bladder epithelial cells using a novel mounting method ⬇️

scientific article published on November 1, 1991

Molecular and functional mapping of regional differences in P2Y receptor expression in the rat lens.

scientific article published on 21 May 2008

Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens

scientific journal article

Molecular identification and cellular localisation of GSH synthesis, uptake, efflux and degradation pathways in the rat ciliary body

scientific article published on 15 November 2012

Molecular identification and cellular localization of a potential transport system involved in cystine/cysteine uptake in human lenses

scientific article published on 19 September 2013

Molecular identification and characterisation of the glycine transporter (GLYT1) and the glutamine/glutamate transporter (ASCT2) in the rat lens.

scientific article

Molecular identification and localization of P2X receptors in the rat lens

Novel roles for the lens in preserving overall ocular health

scientific article

Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies

scientific article published on 27 May 2019

Ocular lens gap junctions: protein expression, assembly, and structure-function analysis.

scientific article published on August 1995

Point: A critical appraisal of the lens circulation model--an experimental paradigm for understanding the maintenance of lens transparency?

scientific article

Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress

scientific article published on 24 March 2010

Reconstitution of channels from preparations enriched in lens gap junction protein MP70

scientific article published on 01 August 1992

Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core

scientific article

Regulation of lens volume: implications for lens transparency

scientific article published on 28 May 2008

Reply to: The Lens Fluid Circulation Model—A Critical Appraisal

Reversing the age-dependent decline in lens transport: a new strategy to prevent age related nuclear cataract?

scientific article published in November 2013

Review of the Experimental Background and Implementation of Computational Models of the Ocular Lens Microcirculation.

scientific article published on 21 June 2016

Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage ⬇️

scientific article published on August 1, 1998

Spatial distributions of AQP5 and AQP0 in embryonic and postnatal mouse lens development.

scientific article published on 13 January 2015

The Effects of Maternal Under-Nutrition and a Post-Natal High Fat Diet on Lens Growth, Transparency and Oxidative Defense Systems in Rat Offspring.

scientific article published on 9 September 2016

The Phosphoinosotide 3-Kinase Catalytic Subunit p110α is Required for Normal Lens Growth.

scientific article published on June 2016

The lens circulation.

scientific article published on March 2007

The lens internal microcirculation system delivers solutes to the lens core faster than would be predicted by passive diffusion

scientific article published on 29 August 2018

The physiological optics of the lens

scientific article published on 14 September 2016

Tools to fight the cataract epidemic: A review of experimental animal models that mimic age related nuclear cataract

scientific article published on 18 September 2015

Two distinct levels of gap junction assembly in vitro

scientific article published on 01 January 1993

Verification and spatial localization of aquaporin-5 in the ocular lens ⬇️

scientific article published on January 8, 2013

Visualization of transverse diffusion paths across fiber cells of the ocular lens by small animal MRI.

scientific article

Visualizing ocular lens fluid dynamics using MRI: manipulation of steady state water content and water fluxes.

scientific article

Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract

scientific article published on 14 October 2020

Whole-cell patch clamping of isolated fiber cells confirms that spatially distinct Cl- influx and efflux pathways exist in the cortex of the rat lens.

scientific article published on 11 March 2009

List of works by Paul Donaldson

A computer model of lens structure and function predicts experimental changes to steady state properties and circulating currents

A link between maternal malnutrition and depletion of glutathione in the developing lens: a possible explanation for idiopathic childhood cataract?

Active Maintenance of the Gradient of Refractive Index Is Required to Sustain the Optical Properties of the Lens.

Alterations of Glutamate, Glutamine, and Related Amino Acids in the Anterior Eye Secondary to Ischaemia and Reperfusion ⬇️

An exploration into diffusion tensor imaging in the bovine ocular lens.

Antioxidant delivery pathways in the anterior eye.

Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements.

Cellular Localization of Glutamate and Glutamine Metabolism and Transport Pathways in the Rat Ciliary Epithelium

Characterization of glutathione uptake, synthesis, and efflux pathways in the epithelium and endothelium of the rat cornea.

Characterization of the Effects of Hyperbaric Oxygen on the Biochemical and Optical Properties of the Bovine Lens.

Characterization of the cystine/glutamate transporter in the outer plexiform layer of the vertebrate retina

Cl- influx into rat cortical lens fiber cells is mediated by a Cl- conductance that is not ClC-2 or -3.

Confocal microscopy reveals zones of membrane remodeling in the outer cortex of the human lens

Development of a 3D finite element model of lens microcirculation

Differential membrane redistribution of P2X receptor isoforms in response to osmotic and hyperglycemic stress in the rat lens

Differentiation-dependent changes in the membrane properties of fiber cells isolated from the rat lens

Differentiation-dependent modification and subcellular distribution of aquaporin-0 suggests multiple functional roles in the rat lens.

Dynamic regulation of GSH synthesis and uptake pathways in the rat lens epithelium

Effects of ADH on the apical and basolateral membranes of toad urinary bladder epithelial cells.

Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract

Fatty Acid uptake and incorporation into phospholipids in the rat lens

Fluid in Equals Fluid Out—Evidence for Circulating Fluid Fluxes in the Lens ⬇️

Focus on molecules: the cystine/glutamate exchanger (System x(c)(-)).

Functional imaging: new views on lens structure and function.

Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens.

Glutamate metabolic pathways and retinal function

Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens

Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues

Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.

Intracellular ionic activities in the EDL muscle of the mouse

Localised fibre cell swelling characteristic of diabetic cataract can be induced in normal rat lens using the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid

MALDI imaging mass spectrometry of β- and γ-crystallins in the ocular lens

Magnetic resonance and confocal imaging of solute penetration into the lens reveals a zone of restricted extracellular space diffusion

Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix-assisted laser desorption/ionisation imaging mass spectrometry method

Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core

Microelectrode studies of toad urinary bladder epithelial cells using a novel mounting method ⬇️

Molecular and functional mapping of regional differences in P2Y receptor expression in the rat lens.

Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens

Molecular identification and cellular localisation of GSH synthesis, uptake, efflux and degradation pathways in the rat ciliary body

Molecular identification and cellular localization of a potential transport system involved in cystine/cysteine uptake in human lenses

Molecular identification and characterisation of the glycine transporter (GLYT1) and the glutamine/glutamate transporter (ASCT2) in the rat lens.

Molecular identification and localization of P2X receptors in the rat lens

Novel roles for the lens in preserving overall ocular health

Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies

Ocular lens gap junctions: protein expression, assembly, and structure-function analysis.

Point: A critical appraisal of the lens circulation model--an experimental paradigm for understanding the maintenance of lens transparency?

Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress

Reconstitution of channels from preparations enriched in lens gap junction protein MP70

Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core

Regulation of lens volume: implications for lens transparency

Reply to: The Lens Fluid Circulation Model—A Critical Appraisal

Reversing the age-dependent decline in lens transport: a new strategy to prevent age related nuclear cataract?

Review of the Experimental Background and Implementation of Computational Models of the Ocular Lens Microcirculation.

Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage ⬇️

Spatial distributions of AQP5 and AQP0 in embryonic and postnatal mouse lens development.

The Effects of Maternal Under-Nutrition and a Post-Natal High Fat Diet on Lens Growth, Transparency and Oxidative Defense Systems in Rat Offspring.

The Phosphoinosotide 3-Kinase Catalytic Subunit p110α is Required for Normal Lens Growth.

The lens circulation.

The lens internal microcirculation system delivers solutes to the lens core faster than would be predicted by passive diffusion

The physiological optics of the lens

Tools to fight the cataract epidemic: A review of experimental animal models that mimic age related nuclear cataract

Two distinct levels of gap junction assembly in vitro

Verification and spatial localization of aquaporin-5 in the ocular lens ⬇️

Visualization of transverse diffusion paths across fiber cells of the ocular lens by small animal MRI.

Visualizing ocular lens fluid dynamics using MRI: manipulation of steady state water content and water fluxes.

Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract

Whole-cell patch clamping of isolated fiber cells confirms that spatially distinct Cl- influx and efflux pathways exist in the cortex of the rat lens.