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List of works by Stefan Nierkens

"Immune" Thrombocytopenia as Key Feature of a Novel ADA2 Deficiency Variant: Implication on Differential Diagnostics of ITP in Children

scientific article published on 01 March 2019

A "No-Touch" Antibody-Staining Method of Adherent Cells for High-Throughput Flow Cytometry in 384-Well Microplate Format for Cell-Based Drug Library Screening

scientific article published on 26 December 2019

A panel of biomarkers for disease severity in atopic dermatitis

scientific article published on 01 March 2015

A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma

scientific article published on 14 September 2013

Adaptation of exercise-induced stress in well-trained healthy young men.

scientific article published on 3 November 2016

An Ocular Protein Triad Can Classify Four Complex Retinal Diseases.

scientific article published on 27 January 2017

Anti-inflammatory and immune regulatory properties of 5-androsten-3beta, 17beta-diol (HE2100), and synthetic analogue HE3204: implications for treatment of autoimmune diseases.

scientific article published in June 2005

Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

scientific article published on 27 March 2013

Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children.

scientific article

Antithymocyte globulin: Importance of good clinical pharmacological practice.

scientific article

Antitumor immune responses mediated by dendritic cells: How signals derived from dying cancer cells drive antigen cross-presentation

scientific article

Assessment of drug-induced immunotoxicity in animal models

scientific article published on 01 January 2006

Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma

scientific article published on 01 February 2001

Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis

scientific article

Automated identification of leukocyte subsets improves standardization of database-guided expert-supervised diagnostic orientation in acute leukemia: a EuroFlow study

scientific article published on 30 September 2020

Biomarkers detected in dried blood spots from atopic dermatitis patients strongly correlate with disease severity

scientific article published on 05 August 2019

CD4+ T-cell reconstitution predicts Survival Outcomes after acute Graft-versus-Host-Disease; a dual center validation

scientific article published on 04 November 2020

CD4+CD25+ T cells regulate the intensity of hypersensitivity responses to peanut, but are not decisive in the induction of oral sensitization

scientific article published on 01 April 2007

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo

scientific article published in July 2007

CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization

article

Candidate Serum Markers in Early Crohn's Disease: Predictors of Disease Course

scientific article published on 27 March 2017

Challenges in the harmonization of immune monitoring studies and trial design for cell-based therapies in the context of hematopoietic cell transplantation for pediatric cancer patients.

scientific article published on December 2015

Chemical-specific properties co-determine the type of adverse immune response.

scientific article

Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation

scientific article published on 25 September 2020

Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation

scientific article published on 19 January 2020

Clofarabine-fludarabine-busulfan in HCT for pediatric leukemia: an effective, low toxicity, TBI-free conditioning regimen

scientific article published on 01 March 2022

Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord blood transplantation

scientific article

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

scientific article published on 08 June 2020

Cord-Blood-Stem-Cell-Derived Conventional Dendritic Cells Specifically Originate from CD115-Expressing Precursors

scientific article published on 05 February 2019

Correlation between measurement of IL-10 and IL-6 in paired aqueous humour and vitreous fluid in primary vitreoretinal lymphoma

scientific article published on 02 April 2015

Dendritic Cell Therapy in an Allogeneic-Hematopoietic Cell Transplantation Setting: An Effective Strategy toward Better Disease Control?

scientific article

Dendritic Cells

Dendritic cells: tools and targets for antitumor vaccination

scientific article

Development of Mucosal PNAd+ and MAdCAM-1+ Venules during Disease Course in Ulcerative Colitis

scientific article published on 06 April 2020

Development of a unique anti-AML immune therapy consisting of cord blood HSCT and cord blood stem cell-derived dendritic cell (CB-DC) vaccination.

scientific article published on 7 November 2013

Development of an oral exposure mouse model to predict drug-induced hypersensitivity reactions by using reporter antigens.

scientific article published on 27 October 2004

Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review

scientific article published on 29 May 2018

Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics.

scientific article

Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin

scientific article

Drug-induced type 1 and type 2 immune responses are characterized by distinct profiles of cell kinetics, cytokine production, and expression of co-stimulatory molecules in the popliteal lymph node assay

scientific article published in July 2005

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry

scientific article published on 31 October 2019

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

scientific article published on 24 July 2020

EASI p-EASI: Utilizing a combination of serum biomarkers offers an objective measurement tool for disease severity in atopic dermatitis patients

scientific article published on 16 August 2017

EASI p-EASI: predicting disease severity in atopic dermatitis patients treated with Cyclosporin A

scientific article published on 16 December 2018

Early identification of atopic dermatitis patients in need of systemic immunosuppressive treatment

scientific article published on 30 September 2019

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study

Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity.

scientific article published on 5 September 2006

Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model

scientific article published in April 2008

Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells.

scientific article published on 19 October 2017

Evaluation of the use of reporter antigens in an auricular lymph node assay to assess the immunosensitizing potential of drugs.

scientific article published on 19 February 2004

Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation.

scientific article

FACSCanto II and LSRFortessa flow cytometer instruments can be synchronized utilizing single-fluorochrome-conjugated surface-dyed beads for standardized immunophenotyping

scientific article published on 20 May 2020

Filgrastim enhances T-cell clearance by antithymocyte globulin exposure after unrelated cord blood transplantation

scientific article published on 01 March 2018

Fine-Tuning Antithymocyte Globulin Dosing and Harmonizing Clinical Trial Design.

scientific article published on 7 February 2018

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes

scientific article published on 01 July 2019

Galectin-9 and CXCL10 as Biomarkers for Disease Activity in Juvenile Dermatomyositis: A Longitudinal Cohort Study and Multicohort Validation

scientific article published on 12 March 2019

Gene Augmentation and Editing to Improve TCR Engineered T Cell Therapy against Solid Tumors

scientific article published on 03 December 2020

Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation.

scientific article

Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice

scientific article published on 2 February 2009

Harnessing dendritic cells for tumor antigen presentation

scientific article published on 26 April 2011

High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

scientific article published on 31 October 2018

How to define and measure thymopoiesis after transplantation?

scientific article published on 03 May 2018

Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation

scientific article published on 01 February 2018

Human neonatal thymectomy induces altered B-cell responses and auto-reactivity.

scientific article published on 10 July 2017

Hurdles in treating Hurler disease: potential routes to achieve a "real" cure

scientific article published on 01 June 2020

Immune Monitoring After Allogeneic Hematopoietic Cell Transplantation: Toward Practical Guidelines and Standardization

scientific article published on 21 August 2020

Immune Reconstitution after Allogeneic Hematopoietic Cell Transplantation in Children

scientific article published on September 2015

Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

scientific article

Immune monitoring and treatment in immune-mediated inflammatory diseases

scientific article published on 7 June 2022

Immune reconstitution and outcomes after conditioning with anti-thymocyte-globulin in unrelated cord blood transplantation; the good, the bad, and the ugly.

scientific article published on 16 May 2017

In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy

scientific article

Increased prevalence of gastrointestinal viruses and diminished secretory immunoglobulin a levels in antibody deficiencies

scientific article

Innate immune recovery predicts CD4+ T-cell reconstitution after Hematopoietic Cell Transplantation

article

Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets

scientific article published on 10 May 2012

Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions.

scientific article published in December 2004

Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis

scientific article published on 9 May 2016

Long-term effect of hematopoietic cell transplantation on systemic inflammation in patients with mucopolysaccharidoses

scientific article published on 01 August 2021

Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation

scientific article published on 26 July 2021

MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

scientific article published on 02 July 2020

MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma

scientific article published on 08 November 2018

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

scientific article published in 2022

Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences

scientific article published on 22 December 2016

Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses

scientific article published on 9 September 2016

Monitoring Immune Responses in Neuroblastoma Patients during Therapy

scientific article published on 24 February 2020

Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis

scientific article published on 12 April 2017

Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation

scientific article

Murine models of drug hypersensitivity

scientific article

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

scientific article

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma

scientific article published on 13 September 2018

Peripheral neuropathy in metachromatic leukodystrophy: current status and future perspective

scientific article published on 04 November 2019

Pharmacological Considerations in Antithymocyte Globulin Exposure Calculation

scientific article published on 27 March 2019

Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide.

scientific article published on 4 December 2018

Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

scientific article

Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations

Phenotypic variability including Behçet's disease-like manifestations in DADA2 patients due to a homozygous c.973-2A>G splice site mutation

scientific article published on 01 November 2019

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

scientific article

Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

scientific article published on 01 May 2019

Potential Diagnosis of Vitreoretinal Lymphoma by Detection of MYD88 Mutation in Aqueous Humor With Ultrasensitive Droplet Digital Polymerase Chain Reaction

scientific article published on 01 October 2018

Predictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children

scientific article published on 22 July 2019

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

scientific article published on 18 August 2010

QuantiFERON-plus does not discriminate between active and latent tuberculosis

scientific article

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry

scientific article published on 06 February 2020

Quantification of neutralizing anti-drug antibodies and their neutralizing capacity using competitive displacement and tandem mass spectrometry: Infliximab as proof of principle

scientific article published on 01 April 2019

Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry

scientific article published on 25 June 2018

Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

scientific article published on 02 June 2020

Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation

scientific article published on 20 July 2020

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

scientific article published on 21 November 2008

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

scientific article published on January 2012

Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice

scientific article

Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction

scientific article published on 30 November 2011

Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo.

scientific article published on 14 January 2011

Selective requirement for CD40-CD154 in drug-induced type 1 versus type 2 responses to trinitrophenyl-ovalbumin.

scientific article

Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

scientific article published in 2021

Serum biomarker profiles suggest that atopic dermatitis is a systemic disease

scientific article published in February 2018

Strategies before, during, and after hematopoietic cell transplantation to improve T-cell immune reconstitution.

scientific article published on 3 October 2016

Strategies to Genetically Modulate Dendritic Cells to Potentiate Anti-Tumor Responses in Hematologic Malignancies.

scientific article published on 18 May 2018

Synergy between In situ Cryoablation and TLR9 Stimulation Results in a Highly Effective In vivo Dendritic Cell Vaccine

scientific article published on 01 July 2006

Systemic inflammatory immune signatures in a patient with CRB1 linked retinal dystrophy

scientific article published on 3 October 2016

TLR ligands in the local treatment of established intracerebral murine gliomas.

scientific article

Targeted Proteomics Reveals Inflammatory Pathways that Classify Immune Dysregulation in Common Variable Immunodeficiency

scientific article published on 15 November 2020

The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins

article

The cellular composition and function of the bone marrow niche after allogeneic hematopoietic cell transplantation

scientific article published in 2022

The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology

scientific article published on 17 December 2020

The magnitude of cytokine production by stimulated CD56+ cells is associated with early stages of systemic sclerosis

scientific article published on 8 September 2016

The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells

scientific article published in May 2005

The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children.

scientific article published in February 2003

The reporter antigen popliteal lymph node assay

scientific article published on 01 January 2006

Third party, umbilical cord blood derived regulatory T-cells for prevention of graft versus host disease in allogeneic hematopoietic stem cell transplantation: feasibility, safety and immune reconstitution

article by Joshua N Kellner et al published 2 November 2018 in Oncotarget

Toll-like receptor signalling on Tregs: to suppress or not to suppress?

scientific article published on 28 June 2008

Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes

scientific article published on 01 May 2020

Use of cord blood derived T-cells in cancer immunotherapy: milestones achieved and future perspectives.

scientific article

Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation

scientific article published on 6 April 2017

Will post-transplantation cell therapies for pediatric patients become standard of care?

scientific article

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