Search filters

List of works by Rennolds S. Ostrom

A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.

scientific article published on 26 July 2016

A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention"

scientific article published on 22 January 2014

A two-pronged weapon in the fight against fibrosis. Focus on "Inhibition of Wnt/β-catenin signaling promotes epithelial differentiation of mesenchymal stem cells and repairs bleomycin-induced lung injury"

scientific article published on 04 June 2014

Adenylyl Cyclase 2 Selectively Couples to E Prostanoid Type 2 Receptors, Whereas Adenylyl Cyclase 3 Is Not Receptor-Regulated in Airway Smooth Muscle ⬇️

scientific article published on May 22, 2012

Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis.

scientific article published on 11 November 2013

Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.

scientific article published on 13 October 2007

Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts

scientific article published on 28 December 2019

An orphan GPCR finds a home in the heart

scientific article published on 27 June 2008

Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts

scientific journal article

CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts.

scientific article published on 04 June 2009

Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes.

scientific article

Caveolar microdomains of the sarcolemma: compartmentation of signaling molecules comes of age

scientific article published on 01 May 1999

Caveolins muscle their way into the regulation of cell differentiation, development, and function. Focus on “Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells.”

article

Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways.

scientific article

Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells.

scientific article

Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor

scientific article

Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.

scientific article

Fibrotic lung fibroblasts show blunted inhibition by cAMP due to deficient cAMP response element-binding protein phosphorylation.

scientific article

Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

scientific article published in June 2003

Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region.

scientific article published in July 2017

Human Bronchial Smooth Muscle Cells Express Adenylyl Cyclase Isoforms 2, 4, and 6 in Distinct Membrane Microdomains ⬇️

scientific article published on January 12, 2011

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

scientific article published on April 2017

Melatonin membrane receptors in peripheral tissues: distribution and functions

scientific article published on 8 January 2012

New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains.

scientific article

Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes

scientific journal article

Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms

scientific journal article

P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides.

scientific article published on April 2001

Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase.

scientific article

Subtypes of the muscarinic receptor in smooth muscle ⬇️

scientific article published on January 1, 1997

Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis

scientific article

The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae.

scientific article

The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder.

scientific article

The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum

scientific article published on 07 July 2009

cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts

scientific journal article

cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts.

scientific article published on 7 January 2004

Paulina is supported by:

About Paulina

Help