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List of works by Joachim Brouwers

A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.

scientific article published on 29 August 2013

An In-Depth View into Human Intestinal Fluid Colloids: Intersubject Variability in Relation to Composition

scientific article published on 31 August 2016

An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation

scientific article

Assessment of Passive Intestinal Permeability Using an Artificial Membrane Insert System

scientific article

Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field-Flow Fractionation/Multiangle Laser Light Scattering.

scientific article

CADA, a Potential Anti-HIV Microbicide that Specifically Targets the Cellular CD4 Receptor

article

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor

scientific article published in May 2008

Capillary zone electrophoresis method development for the analysis of Hippeastrum hybrid agglutinin samples.

scientific article published on 31 December 2008

Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions.

scientific article published on 30 July 2015

Determination of intraluminal theophylline concentrations after oral intake of an immediate- and a slow-release dosage form.

scientific article published in August 2005

Development and characterization of a solid dispersion film for the vaginal application of the anti-HIV microbicide UAMC01398.

scientific article published on 28 August 2014

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

scientific article published on 20 November 2013

Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection

scientific article

Drug permeability profiling using cell-free permeation tools: Overview and applications

scientific article published on 13 April 2018

Drug precipitation–permeation interplay: Supersaturation in an absorptive environment ⬇️

scientific article published on July 25, 2012

Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.

scientific article published on November 2010

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir

scientific article published on 6 June 2011

Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole

scientific article published on 01 November 2011

Ethanol concentrations in the human gastrointestinal tract after intake of alcoholic beverages

scientific article

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

scientific article published on 12 December 2014

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

scientific article published on 26 November 2014

Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

scientific article

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

scientific article published on 29 October 2009

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

scientific article published on 22 February 2011

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

scientific article published on 30 November 2016

Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir

scientific article published on 17 July 2020

Exploring the link between gastric motility and intragastric drug distribution in man

scientific article published on 16 November 2016

Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

scientific article

Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions.

scientific article published on 21 July 2017

Gastrointestinal Behavior of Weakly Acidic BCS Class II Drugs in Man—Case Study of Diclofenac Potassium

scientific article published on 29 January 2016

Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools

scientific article published on 16 June 2017

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.

scientific article published on 10 May 2016

Gastrointestinal behavior of itraconazole in humans - Part 1: Supersaturation from a solid dispersion and a cyclodextrin-based solution

scientific article published on 13 April 2017

Gastrointestinal behavior of itraconazole in humans - Part 2: The effect of intraluminal dilution on the performance of a cyclodextrin-based solution.

scientific article published on 24 April 2017

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

scientific article

Gastrointestinal dissolution, supersaturation and precipitation of the weak base indinavir in healthy volunteers

scientific article

Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools.

scientific article published on 23 July 2014

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation and Precipitation of Posaconazole.

scientific article

In Vitro Evaluation of Viability, Integrity, and Inflammation in Genital Epithelia upon Exposure to Pharmaceutical Excipients and Candidate Microbicides ⬇️

scientific article published on October 4, 2010

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

scientific article

In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: Illustration of intraluminal supersaturation

scientific article published on 14 December 2006

In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.

scientific article

In vitro models for the prediction of in vivo performance of oral dosage forms

scientific article published on 27 August 2013

In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients

article

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

scientific article published on 15 March 2014

Intestinal behavior of the ester prodrug tenofovir DF in humans

scientific article published on 4 March 2015

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids ⬇️

scientific article published on July 17, 2011

Llama antibody fragments have good potential for application as HIV type 1 topical microbicides.

scientific article published on 24 August 2011

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

scientific article (publication date: 2012)

Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.

scientific article published on 19 April 2007

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

scientific article published on 7 March 2009

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

scientific article published on 12 January 2015

Resolving intraluminal drug and formulation behavior: Gastrointestinal concentration profiling in humans

scientific article published on 02 February 2014

Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?

scientific article

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans.

scientific article published on 22 February 2016

Supersaturation in human gastric fluids

scientific article published on 11 February 2012

The Effect of Sparkling Water on Intraluminal Formulation Behavior and Systemic Drug Performance

scientific article published on 6 April 2017

The artificial membrane insert system as predictive tool for formulation performance evaluation.

scientific article published on 12 December 2017

The dynamic gastric environment and its impact on drug and formulation behaviour.

scientific article

The use of supersaturation for the vaginal application of microbicides: a case study with dapivirine.

scientific article published on 17 September 2014

Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.

scientific article

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