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List of works by Edwin Choy

A novel target for treatment of chordoma: signal transducers and activators of transcription 3.

scientific article published in September 2009

Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis.

scientific article

Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels

scientific article published on 8 March 2007

Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma

scientific article published in August 2010

Case records of the Massachusetts General Hospital. Case 36-2009. A 23-year-old man with cough, hoarseness, and abnormalities on chest imaging

scientific article published on 01 November 2009

Characterization and analysis of human chordoma cell lines

scientific article published in June 2010

Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.

scientific article published in June 2009

Corrigendum to "SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy"

scientific article published on 27 August 2019

Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.

scientific article

Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells

scientific article

Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series.

scientific article

Differences in sex distribution, anatomic location and MR imaging appearance of pediatric compared to adult chordomas

scientific article published on 8 September 2016

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression

scientific article published in June 2010

Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines.

scientific article published on October 2008

Efficacy and Safety of Regorafenib in Patients With Metastatic and/or Unresectable GI Stromal Tumor After Failure of Imatinib and Sunitinib: A Multicenter Phase II Trial ⬇️

scientific article published on May 21, 2012

Establishment and characterization of a novel chordoma cell line: CH22.

scientific article published on 13 April 2012

Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma

scientific article published in May 2015

Frequency and Risk Factors for Additional Lesions in the Axial Spine in Subjects With Chordoma: Indications for Screening

scientific article published on 31 May 2016

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines

scientific article

Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma

scientific article published on 08 March 2022

High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes

scientific article

Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines ⬇️

scientific article published on April 1, 2011

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma

scientific article

Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo.

scientific article published on June 2011

Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.

scientific article published on 28 July 2009

Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma

scientific article

Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas

scientific article published on 16 December 2011

MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration ⬇️

scientific article published on June 10, 2011

Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay

scientific article

NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance

scientific article

Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: A 10-year single institution retrospective study ⬇️

scientific article published on October 22, 2012

Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

scientific article

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

scientific article published on 25 January 2021

Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas

scientific article

Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution

scientific article published on 13 December 2019

Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma

scientific article published on 5 February 2014

Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma

scientific article published on 29 March 2011

Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas

scientific article

ROCK1 as a potential therapeutic target in osteosarcoma ⬇️

scientific article published on March 8, 2011

Role of epigenetic modulation for the treatment of sarcoma.

scientific article published on September 2013

SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy

scientific article published on 24 October 2018

Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study

scientific article published on 16 July 2013

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma

scientific article

Synthesis and Evaluation of (2-(4-Methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) Isomers To Reverse Multidrug Resistance in Cancer ⬇️

scientific article published on March 22, 2012

Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation

scientific article

Targeting hedgehog-GLI-2 pathway in osteosarcoma.

scientific article published on 11 September 2012

The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies

scientific article published on 23 December 2020

The kinase Mirk is a potential therapeutic target in osteosarcoma

scientific article

The role of the CD58 locus in multiple sclerosis

scientific article

Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma

scientific article published on 23 September 2013

Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial

scientific article

Updated Outcome and Analysis of Tumor Response in Mobile Spine and Sacral Chordoma Treated With Definitive High-Dose Photon/Proton Radiation Therapy

scientific article

ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines

scientific article

β-Catenin mutation status and outcomes in sporadic desmoid tumors.

scientific article published on 19 August 2013

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