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List of works by Santi Spampinato

(+)-cis-N-Ethyleneamino-N-normetazocine Derivatives. Novel and Selective σ Ligands with Antagonist Properties ⬇️

scientific article published on May 7, 1998

1‘-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4‘-piperidine] (Spipethiane), a Potent and Highly Selective σ1 Ligand ⬇️

scientific article published on May 7, 1998

2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives: Novel, potent and selective σ1 receptor ligands ⬇️

scientific article published on September 24, 1997

5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists

scientific article published on 25 July 2015

A Blocking Group Scan Using a Spherical Organometallic Complex Identifies an Unprecedented Binding Mode with Potent Activity In Vitro and In Vivo for the Opioid Peptide Dermorphin

scientific article

ACTH1-24 counteracts the prolactin-releasing effect of an opioid.

scientific article published in January 1982

Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells

scientific article

Agonist-regulated endocytosis and desensitization of the human nociceptin receptor

scientific article published in February 2006

Agonist-regulated internalization and desensitization of the human nociceptin receptor expressed in CHO cells.

scientific article published on January 2007

Analysis of azide-insensitive Ca2+-dependent ATPase activity in atrial specimens from patients with coronary or valvular heart disease

scientific article published on 01 September 1987

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines

scientific article

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

scientific article

Antinociception by a peripherally administered novel endomorphin-1 analogue containing beta-proline

scientific article

Antinociceptive activity of salmon calcitonin injected intrathecally in the rat

scientific article published on 01 March 1984

Antisense versus proopiomelanocortin mRNA reduces vascular risk in a murine model of type-2 diabetes following stress exposure in early post-natal life

scientific article published on 30 December 2014

Biocompatibility and integrin-mediated adhesion of human osteoblasts to poly(DL-lactide-co-glycolide) copolymers

scientific article published on 01 February 2004

Bivalent opioid peptides synthesized from μ selective monomers display preferential selectivity for δ receptors

CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.

scientific article published in January 1995

Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells

scientific article published on 01 January 1993

Changes induced by DMet2-pro5-enkephalinamide in plasma insulin response to glucose in the rat

scientific article published on 01 November 1979

Characterization of a putative calcitonin receptor in IMR 32 human neuroblastoma cells

scientific article published on 01 October 1999

Characterization of dynorphin A-induced antinociception at spinal level

scientific article published on 01 March 1985

Conformational analysis and mu-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

scientific article

Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine.

scientific article

Cyclotetrapeptide Mimics Based on a 13-Membered, Partially Modified Retro-Inverso Structure

article published in 2008

DS-70, a novel and potent α integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs

scientific article published on 17 September 2018

Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.

scientific article published on 5 May 2015

Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as reve

scientific article published on 01 September 1994

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

scientific article published on 26 September 2011

Differential effects of estrogen and antiestrogen on expression of prodynorphin gene in the rat hypothalamus and pituitary

scientific article published on 01 November 1989

Differential effects of modified beta-cyclodextrins on pharmacological activity and bioavailability of 4-biphenylacetic acid in rats after oral administration

scientific article published on 01 February 1995

Diphenidol-related diamines as novel muscarinic M4 receptor antagonists

scientific article

Distinguishable effects of intrathecal dynorphins, somatostatin, neurotensin and s-calcitonin on nociception and motor function in the rat

scientific article published on 01 October 1988

Dynorphin A-(1-17) and dynorphin B are released from in vitro superfused rat hypothalami. Effects of depolarizing agents and ovariectomy

scientific article published on May 15, 1992

Dynorphin B-like immunoreactivity in gastroduodenal biopsy specimens from gallstone patients

scientific article published on 01 September 1992

Effects of specific bile acids on c-fos messenger RNA levels in human colon carcinoma Caco-2 cells.

scientific article

Endogenous Opioid Peptides and Mental Stress in Congestive Heart Failure Patients ⬇️

scientific article published on January 1, 1998

Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance

scientific article published in June 2002

Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis

scientific article published on 18 July 2005

Enhanced brain performance in mice following postnatal stress

scientific article published on 8 October 2012

Estrogen regulation of prodynorphin gene expression in the rat adenohypophysis: effect of the antiestrogen tamoxifen

scientific article published on 01 April 1995

Etiopathogenesis and Pharmacological Prevention of a Type-2 Diabetes Model in Male Mice

scientific article published on 21 November 2017

Expression of the repressor element-1 silencing transcription factor (REST) is influenced by insulin-like growth factor-I in differentiating human neuroblastoma cells.

scientific article

Gi proteins and calcium in dynorphin-induced hypothermia and behaviour

scientific article published on 01 May 1990

Heterogeneity of immunoreactive dynorphin B - like material in human, rat, rabbit and guinea-pig heart ⬇️

scientific article published on January 1, 1991

Hypothermia elicited by some prodynorphin-derived peptides: opioid and non-opioid actions.

scientific article published on July 1989

Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity

scientific article

Immunoreactive dynorphin in rat tissues and plasma.

scientific article published in January 1983

Increase of plasma ACTH in the rat following the administration of D-met2-pro5-enkephalinamide

scientific article published on 01 May 1980

Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics

scientific article published on 27 January 2007

Inhibition of proopiomelanocortin expression by an oligodeoxynucleotide complementary to beta-endorphin mRNA.

scientific article published on August 1994

Investigation of the interaction between the atypical agonist c[YpwFG] and MOR.

scientific article

Involvement of Brain Serotonin in the Prolactin- Releasing Effect of Opioid Peptides* ⬇️

scientific article published on July 1, 1979

Ligand based approach to L-type calcium channel by imidazo[2,1-b]thiazole-1,4-dihydropyridines: from heart activity to brain affinity

scientific article published on 9 May 2013

Liposomal Delivery of a 30-mer Antisense Oligodeoxynucleotide To Inhibit Proopiomelanocortin Expression† ⬇️

scientific article published on May 1, 1998

Long-term intrathecal morphine and bupivacaine upregulate MOR gene expression in lymphocytes

scientific article published on 4 July 2010

Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy

scientific article published on 10 June 2014

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

scientific article published on 12 June 2013

Naloxone prevents cell-mediated immune alterations in adult mice following repeated mild stress in the neonatal period.

scientific article

Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells

scientific article

New coumarin-based anti-inflammatory drug: putative antagonist of the integrins alphaLbeta2 and alphaMbeta2.

scientific article published in November 2008

New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins

scientific article

Nociceptin-induced internalization of the ORL1 receptor in human neuroblastoma cells

scientific article published in October 2001

Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells

scientific article

Ocular hypotensive action of topical flunarizine in the rabbit: role of sigma 1 recognition sites

scientific article published in December 2002

Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus

scientific article

Opioid peptide modulation of circulatory and endocrine response to mental stress in humans.

scientific article published in January 1997

Opioid peptide modulation of circulatory response to hyperventilation in humans.

scientific article published in August 2000

Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia

scientific article

Overview of genetic analysis of human opioid receptors

scientific article published on January 2015

Overweight and metabolic and hormonal parameter disruption are induced in adult male mice by manipulations during lactation period.

scientific article published on 2 December 2005

Pain and child: a translational hypothesis on the pathophysiology of a mild type-2 diabetes model

scientific article published on 01 March 2011

Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model

scientific article published on 14 August 2010

Pharmacology of spinal peptides affecting sensory and motor functions: Dynorphins, somatostatins and tachykinins ⬇️

scientific article published on February 1, 1991

Phase II drugs under investigation for allergic conjunctivitis

scientific article

Plasma brain natriuretic peptide at rest and after adenosine-induced myocardial ischemia in normotensive and essential hypertensive patients with suspected coronary artery disease

scientific article

Plasma endogenous opioid levels in acute myocardial infarction patients, with and without pain ⬇️

scientific article published on August 1, 1992

Plasma nociceptin/orphanin FQ levels in response to the hyperventilation test in healthy subjects

scientific article published on 25 January 2010

Plasma nociceptin/orphanin FQ levels rise after spontaneous episodes of angina, but not during induced myocardial ischemia.

scientific article published on 26 June 2009

Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and Ca++ channel blocker activity of crambescidin 816.

scientific article published in July 1993

Post-natal stress-induced endocrine and metabolic alterations in mice at adulthood involve different pro-opiomelanocortin-derived peptides.

scientific article published on 19 August 2010

Post-transcriptional inhibition of ornithine decarboxylase induction by zinc in a difluoromethylornithine resistant cell line.

scientific article published on September 1994

Pressor effects of endogenous opioid system during acute episodes of blood pressure increases in hypertensive patients

scientific article

Prodynorphin mRNA expression in adult cultured rat ventricular cardiac myocytes.

scientific article published in March 1993

Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration

scientific article published on 01 December 1978

Prostaglandins in Rat Placenta Following Acute and Chronic Administration of Morphine ⬇️

scientific article published on January 1, 1979

Prostaglandins in the brain of rats given, acutely, and chronically, a hyperthermic dose of met-enkephalin

scientific article published on January 31, 1979

Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis

scientific article

REST is up-regulated by epidermal growth factor in HeLa cells and inhibits apoptosis by influencing histone H3 acetylation

scientific article

Regional distribution of immunoreactive dynorphin A in the human gastrointestinal tract

scientific article published on 01 April 1988

Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells

scientific article published on January 1998

Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor

scientific article published in June 2005

Role of nociceptin/orphanin FQ in thermoregulation

scientific article published on 16 March 2015

Role of the ventromedial hypothalamus in the regulation of adenohypophyseal immunoreactive dynorphin in the rat

scientific article published on 01 October 1988

Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.

scientific article

Selective detection of α4β1 integrin (VLA-4)-expressing cells using peptide-functionalized nanostructured materials mimicking endothelial surfaces adjacent to inflammatory sites

scientific article published on 27 November 2017

Septal grafts restore cognitive abilities and amyloid precursor protein metabolism.

scientific article published on 6 February 2008

Sexual dimorphic evolution of metabolic programming in non-genetic non-alimentary mild metabolic syndrome model in mice depends on feed-back mechanisms integrity for pro-opiomelanocortin-derived endogenous substances

scientific article published on 20 May 2010

Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline

scientific article published in May 2003

Studies on the antinociceptive effect of intrathecal salmon calcitonin

scientific article published on 01 January 1985

Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites

scientific article published on 01 June 2000

Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives

scientific article published on 01 March 1998

Synthesis and assay of retro-α4β1 integrin-targeting motifs

scientific article published on 19 December 2013

Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.

scientific article published in December 2000

Synthesis and binding affinity of cis-(-)- and cis-(+)-N-ethyleneamino-N-nordeoxymetazocine and cis-(-)-N-normetazocine analogues at sigma1, sigma2 and kappa opioid receptors.

scientific article

Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagoni

scientific article published in November 1993

Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds

scientific article

Synthesis and conformational analysis of cyclotetrapeptide mimetic beta-turn templates and validation as 3D scaffolds

scientific article

Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].

scientific article

Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.

scientific article

Synthesis and pharmacological profile of a series of 1-substituted-2-carbonyl derivatives of Diphenidol: novel M4 muscarinic receptor antagonists

scientific article published in March 2008

Synthesis of enantiomerically pure αvβ3 integrin ligands based on a 5,6-dihydropyridin-2-one scaffold

Synthesis of tripeptides containing D-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception

scientific article

Synthesis, characterization and pharmacological profile of tropicamide enantiomers

scientific article published on 01 January 1996

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

scientific article

The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists

article by C Melchiorre et al published 1 January 1995 in Life Sciences

The inverse type II β-turn on D-Trp-Phe, a pharmacophoric motif for MOR agonists

scientific article published on 30 June 2011

Transcription factor REST negatively influences the protein kinase C-dependent up-regulation of human mu-opioid receptor gene transcription

scientific article

Transcriptional activation of human mu-opioid receptor gene by insulin-like growth factor-I in neuronal cells is modulated by the transcription factor REST.

scientific article published on June 2008

Universal Template Approach to Drug Design: Polyamines as Selective Muscarinic Receptor Antagonists ⬇️

scientific article published on October 8, 1998

Vas deferens response to selective opioid receptor agonists in adult mice is impaired following postnatal repeated mild stress

scientific article

Versatile Picklocks To Access All Opioid Receptors: Tuning the Selectivity and Functional Profile of the Cyclotetrapeptide c[Phe-d-Pro-Phe-Trp] (CJ-15,208).

scientific article

Zinc is required for the expression of ornithine decarboxylase in a difluoromethylornithine-resistant cell line.

scientific article published on April 1994

beta-Arrestin 2-mediated heterologous desensitization of IGF-IR by prolonged exposure of SH-SY5Y neuroblastoma cells to a mu opioid agonist

scientific article published on 17 July 2010

beta-Endorphin modulation of pressor response to hyperventilation in hypertensive patients

scientific article published in May 2002

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